Journal of Hepatocellular Carcinoma, Volume 10, Issue (2023)

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Journal of Hepatocellular Carcinoma, Volume 10, Issue (2023)

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ORIGINAL RESEARCH

Article
Identification of a Novel Ferroptosis-Related Gene Signature for Predicting Prognosis and Responsiveness to Immunotherapy in Hepatocellular Carcinoma
Qingbin Wang, Bingkun Wang, Xiaowu Ma, Hongkai Zhuang, Zhiqin Xie, Chenwei Tang, Wenliang Tan, Lei Yang, Changzhen Shang & Yajin Chen
Pages: 1-16
Published online: 10 Jan 2023
AbstractforIdentification of a Novel Ferroptosis-Related Gene Signature for Predicting Prognosis and Responsiveness to Immunotherapy in Hepatocellular Carcinoma | Full Text | References | PDF (13.2 MB) | EPUB
  • 281 Views
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Open Access
Article
Yttrium-90 Radioembolization as the Major Treatment of Hepatocellular Carcinoma
Chun-Yen Yu, Po-Hsun Huang, Leo Leung-Chit Tsang, Hsien-Wen Hsu, Wei-Xiong Lim, Ching-Chun Weng, Tung-Liang Huang, Chien-Chin Hsu, Chao-Long Chen, Hsin-You Ou & Yu-Fan Cheng
Pages: 17-26
Published online: 11 Jan 2023
AbstractforYttrium-90 Radioembolization as the Major Treatment of Hepatocellular Carcinoma | Full Text | References | PDF (3.3 MB) | EPUB
  • 361 Views
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Open Access
Article
Non-Invasive Imaging Biomarkers to Predict the Hepatopulmonary Shunt Fraction Before Transarterial Radioembolization in Patients with Hepatocellular Carcinoma
Charlie Alexander Hamm, Felix Busch, Anna Pöhlmann, Annabella Shewarega, Yubei He, Robin Schmidt, Han Xu, Gero Wieners, Bernhard Gebauer & Lynn Jeanette Savic
Pages: 27-42
Published online: 12 Jan 2023
AbstractforNon-Invasive Imaging Biomarkers to Predict the Hepatopulmonary Shunt Fraction Before Transarterial Radioembolization in Patients with Hepatocellular Carcinoma | Full Text | References | PDF (7.3 MB) | EPUB
  • 300 Views
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Open Access
Article
Nomogram Based on Platelet–Albumin–Bilirubin for Predicting Tumor Recurrence After Surgery in Alpha-Fetoprotein-Negative Hepatocellular Carcinoma Patients
Chengkai Yang, Xiaoya Wu, Jianyong Liu, Huaxiang Wang, Yi Jiang, Zhihong Wei & Qiucheng Cai
Pages: 43-55
Published online: 13 Jan 2023
AbstractforNomogram Based on Platelet–Albumin–Bilirubin for Predicting Tumor Recurrence After Surgery in Alpha-Fetoprotein-Negative Hepatocellular Carcinoma Patients | Full Text | References | PDF (4.5 MB) | EPUB
  • 247 Views
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Open Access
Article
Evaluation of Lactate Dehydrogenase and Alkaline Phosphatase as Predictive Biomarkers in the Prognosis of Hepatocellular Carcinoma and Development of a New Nomogram
Ke Su, Weihong Huang, Xueting Li, Ke Xu, Tao Gu, Yanlin Liu, Juan Song, Keyi Qian, Yaoyang Xu, Hao Zeng, Yipei Yang, Lu Guo & Yunwei Han
Pages: 69-79
Published online: 14 Jan 2023
AbstractforEvaluation of Lactate Dehydrogenase and Alkaline Phosphatase as Predictive Biomarkers in the Prognosis of Hepatocellular Carcinoma and Development of a New Nomogram | Full Text | References | PDF (3.3 MB) | EPUB
  • 381 Views
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Open Access
Article
High Platelet Count is a Potential Prognostic Factor of the Early Recurrence of Hepatocellular Carcinoma in the Presence of Circulating Tumor Cells
Zhan Lu, Yiyue Huang, Juntao Huang, Hang-Hang Ni, Tai Luo, Xingyu Wei, Xue Bai, Lunnan Qi & Bangde Xiang
Pages: 57-68
Published online: 14 Jan 2023
AbstractforHigh Platelet Count is a Potential Prognostic Factor of the Early Recurrence of Hepatocellular Carcinoma in the Presence of Circulating Tumor Cells | Full Text | References | PDF (3.1 MB) | EPUB
  • 377 Views
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Open Access
Article
Efficacy and Safety of Combined Ethanol-Lipiodol Mixture and Drug-Eluting Bead TACE for Large HCC
Yi-Hsuan Chuang, Yu-Fan Cheng, Leo Leung-Chit Tsang, Hsin-You Ou, Hsien-Wen Hsu, Wei-Xiong Lim, Po-Hsun Huang, Ching-Chun Weng & Chun-Yen Yu
Pages: 81-90
Published online: 15 Jan 2023
AbstractforEfficacy and Safety of Combined Ethanol-Lipiodol Mixture and Drug-Eluting Bead TACE for Large HCC | Full Text | References | PDF (1.7 MB) | EPUB
  • 239 Views
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Open Access
Article
Cd34 Immunostaining Adds Specificity To Microvascular invasion Analysis in Hepatocellular Carcinoma
Henrique Gama, Ronniel Albuquerque, David Campos Wanderley, Marcelo Antônio Pascoal Xavier, Fernanda Maria Farage Osório, Cláudia Alves Couto, Teresa Cristina de Abreu Ferrari, Agnaldo S Lima, Paulo Henrique Costa Diniz & Paula Vieira Teixeira Vidigal
Pages: 91-98
Published online: 22 Jan 2023
AbstractforCd34 Immunostaining Adds Specificity To Microvascular invasion Analysis in Hepatocellular Carcinoma | Full Text | References | PDF (3.1 MB) | EPUB
  • 207 Views
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Open Access
Article
Changes in Presentation, Treatment, and Survival of Patients with Hepatocellular Carcinoma in Damietta, Egypt, 2007–2019: A Retrospective Monocentric Cohort Study
Kévin Jean, Ahmed Tawheed, Liem Binh Luong Nguyen, Tarek Heikal, Usama Eldaly, Neveen Elhadidy, Ahmed Elghaieb, Ahmed Aboudonia, Laura Tondeur, Amélie Dublineau, Arnaud Fontanet & Mohamed El-Kassas
Pages: 99-111
Published online: 25 Jan 2023
AbstractforChanges in Presentation, Treatment, and Survival of Patients with Hepatocellular Carcinoma in Damietta, Egypt, 2007–2019: A Retrospective Monocentric Cohort Study | Full Text | References | PDF (1.8 MB) | EPUB
  • 282 Views
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Open Access
Article
Quantitative Assessment of Hypovascular Component in Arterial Phase to Help the Discrimination of Combined Hepatocellular-Cholangiocarcinoma and Hepatocellular Carcinoma
Xue Yang, Jing Chang, Ruili Li, Yu Qi, Xufen Zeng, Wei Wang & Hongjun Li
Pages: 113-122
Published online: 26 Jan 2023
AbstractforQuantitative Assessment of Hypovascular Component in Arterial Phase to Help the Discrimination of Combined Hepatocellular-Cholangiocarcinoma and Hepatocellular Carcinoma | Full Text | References | PDF (3.9 MB) | EPUB
  • 190 Views
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Open Access
Article
Cisplatin or Doxorubicin Reduces Cell Viability via the PTPIVA3-JAK2-STAT3 Cascade in Hepatocellular Carcinoma
Chao-Jen Li, Hung-Wen Tsai, Yi-Li Chen, Chun-I Wang, Yang-Hsiang Lin, Pei-Ming Chu, Hsiang-Cheng Chi, Yi-Ching Huang & Cheng-Yi Chen
Pages: 123-138
Published online: 30 Jan 2023
AbstractforCisplatin or Doxorubicin Reduces Cell Viability via the PTPIVA3-JAK2-STAT3 Cascade in Hepatocellular Carcinoma | Full Text | References | PDF (7.1 MB) | EPUB
  • 292 Views
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Open Access
Article
Development and Validation of a Vascular Endothelial Growth Factor A-associated Prognostic Model for Unresectable Hepatocellular Carcinoma
Kun He, Xinyu Liu & Zelong Yang
Pages: 139-156
Published online: 05 Feb 2023
AbstractforDevelopment and Validation of a Vascular Endothelial Growth Factor A-associated Prognostic Model for Unresectable Hepatocellular Carcinoma | Full Text | References | PDF (6.4 MB) | EPUB
  • 387 Views
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Open Access
Article
Preoperative Evaluation of Hepatocellular Carcinoma Differentiation Using Contrast-Enhanced Ultrasound-Based Deep-Learning Radiomics Model
Xiachuan Qin, Xiaomin Hu, Weihan Xiao, Chao Zhu, Qianqin Ma & Chaoxue Zhang
Pages: 157-168
Published online: 08 Feb 2023
AbstractforPreoperative Evaluation of Hepatocellular Carcinoma Differentiation Using Contrast-Enhanced Ultrasound-Based Deep-Learning Radiomics Model | Full Text | References | PDF (7.7 MB) | EPUB
  • 269 Views
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Open Access
Article
Subcentimeter Nodules with Diagnostic Hallmarks of Hepatocellular Carcinoma: Comparison of Pathological Features and Survival Outcomes with Nodules Measuring 1–2 cm
Peng Huang, Xiaoyan Ni, Changwu Zhou, Zhang Shi, Fei Wu, Yuyao Xiao, Chun Yang & Mengsu Zeng
Pages: 169-180
Published online: 08 Feb 2023
AbstractforSubcentimeter Nodules with Diagnostic Hallmarks of Hepatocellular Carcinoma: Comparison of Pathological Features and Survival Outcomes with Nodules Measuring 1–2 cm | Full Text | References | PDF (3.4 MB) | EPUB
  • 204 Views
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Open Access
Article
Inflammation-Related Marker NrLR Predicts Prognosis in AFP-Negative HCC Patients After Curative Resection
Qionglan Wu, Jinhua Zeng & Jianxing Zeng
Pages: 193-202
Published online: 08 Feb 2023
AbstractforInflammation-Related Marker NrLR Predicts Prognosis in AFP-Negative HCC Patients After Curative Resection | Full Text | References | PDF (6.8 MB) | EPUB
  • 185 Views
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Open Access

REVIEW

Review
Preoperative Immunotherapy in Hepatocellular Carcinoma: Current State of the Art
Alena Laschtowitz, Christoph Roderburg, Frank Tacke & Raphael Mohr
Pages: 181-191
Published online: 08 Feb 2023
AbstractforPreoperative Immunotherapy in Hepatocellular Carcinoma: Current State of the Art | Full Text | References | PDF (475.7 KB) | EPUB
  • 505 Views
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Open Access

ORIGINAL RESEARCH

Article
Novel Nomograms Based on Gamma-Glutamyl Transpeptidase-to-Lymphocyte Ratio Predict Prognosis of Hepatocellular Carcinoma Patients After Hepatectomy
Cheng Ma, Yin Cao, Guang Zhang, Jiannan Qiu, Yan Zhou, Peng Wang, Shuo Wang, Dongliang Yan, Ding Ma, Chunping Jiang & Zhongxia Wang
Pages: 217-230
Published online: 09 Feb 2023
AbstractforNovel Nomograms Based on Gamma-Glutamyl Transpeptidase-to-Lymphocyte Ratio Predict Prognosis of Hepatocellular Carcinoma Patients After Hepatectomy | Full Text | References | PDF (6 MB) | EPUB
  • 185 Views
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Open Access
Article
Ozonated Water Inhibits Hepatocellular Carcinoma Invasion and Metastasis by Regulating the HMGB1/NF-κB/STAT3 Signaling Pathway
Shuiying Tang, Bihong Xu, Huajin Pang, Lijun Xiao, Quelin Mei & Xiaofeng He
Pages: 203-215
Published online: 10 Feb 2023
AbstractforOzonated Water Inhibits Hepatocellular Carcinoma Invasion and Metastasis by Regulating the HMGB1/NF-κB/STAT3 Signaling Pathway | Full Text | References | PDF (7.9 MB) | EPUB
  • 260 Views
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Open Access
Article
Downstaging and Conversation Strategy for Advanced Hepatocellular Carcinoma with Portal Vein Branch Tumor Thrombus: TACE, 125I Seed Implantation, and RFA for Hepatocellular Carcinoma with Portal Vein Branch Tumor Thrombus
Xiao-Hui Zhao, Hai-Liang Li, Chen-Yang Guo, Quan-Jun Yao, Wei-Li Xia & Hong-Tao Hu
Pages: 231-240
Published online: 14 Feb 2023
AbstractforDownstaging and Conversation Strategy for Advanced Hepatocellular Carcinoma with Portal Vein Branch Tumor Thrombus: TACE, 125I Seed Implantation, and RFA for Hepatocellular Carcinoma with Portal Vein Branch Tumor Thrombus | Full Text | References | PDF (2.6 MB) | EPUB
  • 248 Views
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Open Access
Article
Prognosis and Personalized Treatment Prediction in Different Mutation-Signature Hepatocellular Carcinoma
Yuyuan Zhang, Zaoqu Liu, Jie Li, Xin Li, Mengjie Duo, Siyuan Weng, Peijie Lv, Guozhong Jiang, Caihong Wang, Yan Li, Shichao Liu & Zhen Li
Pages: 241-255
Published online: 15 Feb 2023
AbstractforPrognosis and Personalized Treatment Prediction in Different Mutation-Signature Hepatocellular Carcinoma | Full Text | References | PDF (11.4 MB) | EPUB
  • 264 Views
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Open Access

REVIEW

Review
Potential Treatment Strategies for Hepatocellular Carcinoma Cell Sensitization to Sorafenib
Zhonghao Jiang & Chaoliu Dai
Pages: 257-266
Published online: 15 Feb 2023
AbstractforPotential Treatment Strategies for Hepatocellular Carcinoma Cell Sensitization to Sorafenib | Full Text | References | PDF (1.7 MB) | EPUB
  • 354 Views
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Open Access

ORIGINAL RESEARCH

Article
Efficacy and Safety of TACE Combined with Regorafenib Plus PD-1 Inhibitor in the Treatment of Hepatocellular Carcinoma After Sorafenib Resistance
Xinhua Zou, Qingyu Xu, Ran You & Guowen Yin
Pages: 267-279
Published online: 16 Feb 2023
AbstractforEfficacy and Safety of TACE Combined with Regorafenib Plus PD-1 Inhibitor in the Treatment of Hepatocellular Carcinoma After Sorafenib Resistance | Full Text | References | PDF (2.3 MB) | EPUB
  • 266 Views
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Open Access
Article
Significance of Physical Status and Liver Function Reserve for Outcome of Patients with Advanced Hepatocellular Carcinoma Receiving Lenvatinib Treatment
Kun-Ming Chan, Yin Lai, Hao-Chien Hung, Jin-Chiao Lee, Chih-Hsien Cheng, Yu-Chao Wang, Tsung-Han Wu, Chen-Fang Lee, Ting-Jung Wu, Hong-Shiue Chou, Ching-Ting Wang, Pei-Mei Chai, Hsin-Yi Lien & Wei-Chen Lee
Pages: 281-290
Published online: 18 Feb 2023
AbstractforSignificance of Physical Status and Liver Function Reserve for Outcome of Patients with Advanced Hepatocellular Carcinoma Receiving Lenvatinib Treatment | Full Text | References | PDF (2.1 MB) | EPUB
  • 193 Views
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Open Access
Article
PET Imaging of Hepatocellular Carcinoma Using ZD2-(68Ga-NOTA)
Olga Sergeeva, Yifan Zhang, Songqi Gao, E Ricky Chan, Maxim Sergeev, Renuka Iyer, Sandra Sexton, Norbert Avril, Zheng-Rong Lu & Zhenghong Lee
Pages: 291-301
Published online: 22 Feb 2023
AbstractforPET Imaging of Hepatocellular Carcinoma Using ZD2-(68Ga-NOTA) | Full Text | References | PDF (3.5 MB) | EPUB
  • 294 Views
  • 1 CrossRef citations
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Open Access
Article
Exploring Prognosis, Tumor Microenvironment and Tumor Immune Infiltration in Hepatocellular Carcinoma Based on ATF/CREB Transcription Factor Family Gene-Related Model
Honghong Shen, Xianhua Gu, Huiyuan Li, Mingyue Tang, Xinwei Li, Yue Zhang, Fang Su & Zishu Wang
Pages: 327-345
Published online: 27 Feb 2023
AbstractforExploring Prognosis, Tumor Microenvironment and Tumor Immune Infiltration in Hepatocellular Carcinoma Based on ATF/CREB Transcription Factor Family Gene-Related Model | Full Text | References | PDF (19.7 MB) | EPUB
  • 314 Views
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Open Access
Article
Efficacy and Safety of Regorafenib Plus Immune Checkpoint Inhibitors with or Without TACE as a Second-Line Treatment for Advanced Hepatocellular Carcinoma: A Propensity Score Matching Analysis
Xuegang Yang, Heping Deng, Yanyuan Sun, Yi Zhang, Yujie Lu, Guohui Xu & Xiaoqi Huang
Pages: 303-313
Published online: 27 Feb 2023
AbstractforEfficacy and Safety of Regorafenib Plus Immune Checkpoint Inhibitors with or Without TACE as a Second-Line Treatment for Advanced Hepatocellular Carcinoma: A Propensity Score Matching Analysis | Full Text | References | PDF (2.5 MB) | EPUB
  • 225 Views
  • 3 CrossRef citations
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Open Access
Article
ULK1 Depletion Protects Mice from Diethylnitrosamine-Induced Hepatocarcinogenesis by Promoting Apoptosis and Inhibiting Autophagy
Ting Duan, Xin Yang, Jingyu Kuang, Wenjie Sun, Jin Li, Juan Ge, Mohan Zhang, Xiaobo Cai, Peilin Yu, Jun Yang & Xinqiang Zhu
Pages: 315-325
Published online: 27 Feb 2023
AbstractforULK1 Depletion Protects Mice from Diethylnitrosamine-Induced Hepatocarcinogenesis by Promoting Apoptosis and Inhibiting Autophagy | Full Text | References | PDF (6.8 MB) | EPUB
  • 252 Views
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Open Access

REVIEW

Review
Pathogenesis of NAFLD-Related Hepatocellular Carcinoma: An Up-to-Date Review
Yinghui Gao, Ruirui Zhu, Jianxia Dong & Zhiqin Li
Pages: 347-356
Published online: 01 Mar 2023
AbstractforPathogenesis of NAFLD-Related Hepatocellular Carcinoma: An Up-to-Date Review | Full Text | References | PDF (3.8 MB) | EPUB
  • 394 Views
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Open Access

ORIGINAL RESEARCH

Article
Efficacy and Safety of Tyrosine Kinase Inhibitors Alone or Combination with Programmed Death-1 Inhibitors in Treating of Hepatitis C-Related Hepatocellular Carcinoma
Jin Lei, Sibo Yang, Bowen Chen, Linzhi Zhang, Tao Yan, Gangqi Yang, Yue Chen, Yinyin Li, Yinying Lu & Shi Zuo
Pages: 357-367
Published online: 02 Mar 2023
AbstractforEfficacy and Safety of Tyrosine Kinase Inhibitors Alone or Combination with Programmed Death-1 Inhibitors in Treating of Hepatitis C-Related Hepatocellular Carcinoma | Full Text | References | PDF (3 MB) | EPUB
  • 178 Views
  • 1 CrossRef citations
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Open Access
Article
Comprehensive Genomic Profiling Identifies FAT1 as a Negative Regulator of EMT, CTCs, and Metastasis of Hepatocellular Carcinoma
Zi-Li Huang, Ping-Bao Zhang, Jun-Tao Zhang, Feng Li, Ting-Ting Li & Xiu-Yan Huang
Pages: 369-382
Published online: 07 Mar 2023
AbstractforComprehensive Genomic Profiling Identifies FAT1 as a Negative Regulator of EMT, CTCs, and Metastasis of Hepatocellular Carcinoma | Full Text | References | PDF (10.6 MB) | EPUB
  • 224 Views
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Open Access
Article
Vessels That Encapsulate Tumor Clusters (VETC) Predict cTACE Response in Hepatocellular Carcinoma
Chunyu Lin, Yuan He, Mengnan Liu, Aihua Wu, Jing Zhang, Shurong Li, Shuqi Li, Qinghua Cao & Fang Liu
Pages: 383-397
Published online: 07 Mar 2023
AbstractforVessels That Encapsulate Tumor Clusters (VETC) Predict cTACE Response in Hepatocellular Carcinoma | Full Text | References | PDF (6.8 MB) | EPUB
  • 247 Views
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Open Access

REVIEW

Review
Perspectives on the Underlying Etiology of HCC and Its Effects on Treatment Outcomes
Takanori Ito & Mindie H Nguyen
Pages: 413-428
Published online: 10 Mar 2023
AbstractforPerspectives on the Underlying Etiology of HCC and Its Effects on Treatment Outcomes | Full Text | References | PDF (1.7 MB) | EPUB
  • 495 Views
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ORIGINAL RESEARCH

Article
Prognosis of Primary Liver Cancer Based on LI-RADS Classification with Extracellular Agent-Enhanced MRI
Yubo Li, Xiaoyan Ni, Xinai Liu, Chun Yang, Yi Wang, Xin Lu & Changwu Zhou
Pages: 399-411
Published online: 09 Mar 2023
AbstractforPrognosis of Primary Liver Cancer Based on LI-RADS Classification with Extracellular Agent-Enhanced MRI | Full Text | References | PDF (4 MB) | EPUB
  • 230 Views
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Open Access
Article
LncRNA TGFB2-OT1 Promotes Progression and Angiogenesis in Hepatocellular Carcinoma by Dephosphorylating β-Catenin
Yiran Chen, Xiaoling Wu, Xi Chen, Deliang Guo, Weijie Ma, Yonghua Guo, Kequan Xu, Shuxian Ma, Yufeng Yuan & Qian Zhu
Pages: 429-446
Published online: 14 Mar 2023
AbstractforLncRNA TGFB2-OT1 Promotes Progression and Angiogenesis in Hepatocellular Carcinoma by Dephosphorylating β-Catenin | Full Text | References | PDF (13.6 MB) | EPUB
  • 213 Views
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Open Access
Article
The Feasibility of TACE Combined with TKIs Plus PD-1 Antibody for Advanced HCC
Tao Sun, Yanqiao Ren, Bo Sun, Lei Chen, Licheng Zhu, Lijie Zhang & Chuansheng Zheng
Pages: 447-457
Published online: 16 Mar 2023
AbstractforThe Feasibility of TACE Combined with TKIs Plus PD-1 Antibody for Advanced HCC | Full Text | References | PDF (2.4 MB) | EPUB
  • 195 Views
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Open Access
Article
Prognostic Lysosome-Related Biomarkers for Predicting Drug Candidates in Hepatocellular Carcinoma: An Insilco Analysis
Junxiu Xu, Kai Zhang & Genhao Zhang
Pages: 459-472
Published online: 21 Mar 2023
AbstractforPrognostic Lysosome-Related Biomarkers for Predicting Drug Candidates in Hepatocellular Carcinoma: An Insilco Analysis | Full Text | References | PDF (12.4 MB) | EPUB
  • 269 Views
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Open Access
Article
Synergistic Effect of Lenvatinib and Chemotherapy in Hepatocellular Carcinoma Using Preclinical Models
Mingxun Wang, Xinfei Yao, Zhiyuan Bo, Jiuyi Zheng, Haitao Yu, Xiaozai Xie, Zixia Lin, Yi Wang, Gang Chen & Lijun Wu
Pages: 483-495
Published online: 27 Mar 2023
AbstractforSynergistic Effect of Lenvatinib and Chemotherapy in Hepatocellular Carcinoma Using Preclinical Models | Full Text | References | PDF (9.9 MB) | EPUB
  • 271 Views
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Article
Presence of Hepatocellular Carcinoma Does Not Affect Course and Response to Anticoagulation of Bland Portal Vein Thrombosis in Cirrhotic Patients
Francesca Benevento, Anna Pecorelli, Horia Stefanescu, Zeno Sparchez, Ranka Vukotic, Irene Pettinari, Crina-Anca Grigoras, Francesco Tovoli, Federico Ravaioli, Bernardo Stefanini, Pietro Andreone & Fabio Piscaglia
Pages: 473-482
Published online: 27 Mar 2023
AbstractforPresence of Hepatocellular Carcinoma Does Not Affect Course and Response to Anticoagulation of Bland Portal Vein Thrombosis in Cirrhotic Patients | Full Text | References | PDF (454.9 KB) | EPUB
  • 221 Views
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Article
An Analysis Regarding the Association Between Proteasome (PSM) and Hepatocellular Carcinoma (HCC)
Wei Huang, Jia Mei, Yuan-Jie Liu, Jie-Pin Li, Xi Zou, Xiao-Ping Qian & Yu Zhang
Pages: 497-515
Published online: 30 Mar 2023
AbstractforAn Analysis Regarding the Association Between Proteasome (PSM) and Hepatocellular Carcinoma (HCC) | Full Text | References | PDF (18.4 MB) | EPUB
  • 265 Views
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Article
High Expression of Heterogeneous Nuclear Ribonucleoprotein A1 Facilitates Hepatocellular Carcinoma Growth
Ziyi Cao, Li Guan, Runzhi Yu, Fan Yang & Jie Chen
Pages: 517-530
Published online: 01 Apr 2023
AbstractforHigh Expression of Heterogeneous Nuclear Ribonucleoprotein A1 Facilitates Hepatocellular Carcinoma Growth | Full Text | References | PDF (10.7 MB) | EPUB
  • 235 Views
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Article
Identification and Experimental Validation of the Prognostic Significance and Immunological Correlation of Glycosylation-Related Signature and ST6GALNAC4 in Hepatocellular Carcinoma
Tianxing Dai, Jing Li, Run-Bin Liang, Haoyuan Yu, Xu Lu & Guoying Wang
Pages: 531-551
Published online: 03 Apr 2023
AbstractforIdentification and Experimental Validation of the Prognostic Significance and Immunological Correlation of Glycosylation-Related Signature and ST6GALNAC4 in Hepatocellular Carcinoma | Full Text | References | PDF (23.9 MB) | EPUB
  • 277 Views
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Article
Inhibition of Annexin A10 Contributes to ZNF281 Mediated Aggressiveness of Hepatocellular Carcinoma
Xialu Zhang, Chenguang Zhang, Qingfang Zhao, Shanshan Wang, Liyong Wang, Yang Si, Qiang Su, Shan Cheng & Wei Ding
Pages: 553-571
Published online: 05 Apr 2023
AbstractforInhibition of Annexin A10 Contributes to ZNF281 Mediated Aggressiveness of Hepatocellular Carcinoma | Full Text | References | PDF (17 MB) | EPUB
  • 286 Views
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Article
Prognostic Analysis of Single Large Hepatocellular Carcinoma Following Radical Resection: A Single-Center Study
Jian Huang, Li Li, Fu-Chen Liu, Bi-Bo Tan, Yun Yang, Bei-Ge Jiang & Ze-Ya Pan
Pages: 573-586
Published online: 06 Apr 2023
AbstractforPrognostic Analysis of Single Large Hepatocellular Carcinoma Following Radical Resection: A Single-Center Study | Full Text | References | PDF (8.4 MB) | EPUB
  • 190 Views
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Article
Metabolic Tumor Volume Measured by 18F-FDG PET/CT is Associated with the Survival of Unresectable Hepatocellular Carcinoma Treated with PD-1/PD-L1 Inhibitors Plus Molecular Targeted Agents
Xuezhu Wang, Xu Yang, Jingnan Wang, Chengyan Dong, Jie Ding, Meiqi Wu, Yanyu Wang, Haiyan Ding, Hui Zhang, Xinting Sang, Haitao Zhao & Li Huo
Pages: 587-598
Published online: 08 Apr 2023
AbstractforMetabolic Tumor Volume Measured by 18F-FDG PET/CT is Associated with the Survival of Unresectable Hepatocellular Carcinoma Treated with PD-1/PD-L1 Inhibitors Plus Molecular Targeted Agents | Full Text | References | PDF (3.8 MB) | EPUB
  • 279 Views
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Article
Pre-S1 Mutations as Indicated by Serum Pre-S1 Antigen Negative is Associated with an Increased Risk of Hepatocellular Carcinoma in Chronic Hepatitis B Patients
Xingxin Zhang, Chenjian Gu, Qian Wei, Yirong Cao, Weimin She, Hong Shi, Youhua Xie & Jinsheng Guo
Pages: 599-609
Published online: 11 Apr 2023
AbstractforPre-S1 Mutations as Indicated by Serum Pre-S1 Antigen Negative is Associated with an Increased Risk of Hepatocellular Carcinoma in Chronic Hepatitis B Patients | Full Text | References | PDF (1.9 MB) | EPUB
  • 254 Views
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Article
Inhibitory Effects of Esculetin on Liver Cancer Through Triggering NCOA4 Pathway-Mediation Ferritinophagy in vivo and in vitro
Zhiru Xiu, Yiquan Li, Jinbo Fang, Jicheng Han, Shanzhi Li, Yaru Li, Xia Yang, Gaojie Song, Yue Li, Ningyi Jin, Yilong Zhu, Guangze Zhu, Lili Sun & Xiao Li
Pages: 611-629
Published online: 11 Apr 2023
AbstractforInhibitory Effects of Esculetin on Liver Cancer Through Triggering NCOA4 Pathway-Mediation Ferritinophagy in vivo and in vitro | Full Text | References | PDF (21.5 MB) | EPUB
  • 305 Views
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Article
Radiofrequency Ablation of Hepatocellular Carcinomas Adjacent to the Gallbladder Without Isolation Under Contrast-Enhanced Ultrasound Monitoring: A Comparative Study with Long Term Follow-Up
Liping Luo, Ronghua Yan, Qingjing Zeng, Yinglin Long, Xuqi He, Kai Li & Erjiao Xu
Pages: 631-642
Published online: 13 Apr 2023
AbstractforRadiofrequency Ablation of Hepatocellular Carcinomas Adjacent to the Gallbladder Without Isolation Under Contrast-Enhanced Ultrasound Monitoring: A Comparative Study with Long Term Follow-Up | Full Text | References | PDF (2.5 MB) | EPUB
  • 191 Views
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Article
Six-Transmembrane Epithelial Antigen of Prostate 4: An Indicator of Prognosis and Tumor Immunity in Hepatocellular Carcinoma
Mi Ha Ju, Eun Jeong Jang, Sung Hwa Kang, Young Hoon Roh, Jin Sook Jeong & Song-Hee Han
Pages: 643-658
Published online: 20 Apr 2023
AbstractforSix-Transmembrane Epithelial Antigen of Prostate 4: An Indicator of Prognosis and Tumor Immunity in Hepatocellular Carcinoma | Full Text | References | PDF (10.8 MB) | EPUB
  • 244 Views
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Article
A Novel Neutrophil-to-Lymphocyte Ratio and Sarcopenia Based TACE-Predict Model of Hepatocellular Carcinoma Patients
Shangyuan Wang, Xuanpu Zhang, Qi Chen, Zhi-Cheng Jin, Jian Lu & Jinhe Guo
Pages: 659-671
Published online: 20 Apr 2023
AbstractforA Novel Neutrophil-to-Lymphocyte Ratio and Sarcopenia Based TACE-Predict Model of Hepatocellular Carcinoma Patients | Full Text | References | PDF (3.6 MB) | EPUB
  • 214 Views
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Article
Modified Patent Hemostasis Strategy Based on the Platelet Counts for Transradial Access Chemoembolization in Patients with Hepatocellular Carcinoma: A Prospective Single-Center Study
Yin-Gen Luo, Xiao-Wu Zhang, Jiay-Wei Tsauo, Ying Li, Jin-Gui Li, Qing Peng, Ya-Wei Li, Wei Sun, He Zhao & Xiao Li
Pages: 687-695
Published online: 21 Apr 2023
AbstractforModified Patent Hemostasis Strategy Based on the Platelet Counts for Transradial Access Chemoembolization in Patients with Hepatocellular Carcinoma: A Prospective Single-Center Study | Full Text | References | PDF (3.4 MB) | EPUB
  • 182 Views
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Article
A Retrospective Analysis of Conversion Therapy with Lenvatinib, Sintilimab, and Arterially-Directed Therapy in Patients with Initially Unresectable Hepatocellular Carcinoma
Leijuan Gan, Mengran Lang, Xindi Tian, Shaohua Ren, Guangtao Li, Yayue Liu, Ruyu Han, Kangwei Zhu, Huikai Li, Qiang Wu, Yunlong Cui, Wei Zhang, Feng Fang, Qiang Li & Tianqiang Song
Pages: 673-686
Published online: 22 Apr 2023
AbstractforA Retrospective Analysis of Conversion Therapy with Lenvatinib, Sintilimab, and Arterially-Directed Therapy in Patients with Initially Unresectable Hepatocellular Carcinoma | Full Text | References | PDF (4.3 MB) | EPUB
  • 302 Views
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Article
Lenvatinib Induces Immunogenic Cell Death and Triggers Toll-Like Receptor-3/4 Ligands in Hepatocellular Carcinoma
Cheng Zhou, Zhang-Fu Yang, Bao-Ye Sun, Yong Yi, Zheng Wang, Jian Zhou, Jia Fan, Wei Gan, Ning Ren & Shuang-Jian Qiu
Pages: 697-712
Published online: 24 Apr 2023
AbstractforLenvatinib Induces Immunogenic Cell Death and Triggers Toll-Like Receptor-3/4 Ligands in Hepatocellular Carcinoma | Full Text | References | PDF (12.9 MB) | EPUB
  • 429 Views
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REVIEW

Review
Molecular and Clinical Features of Hepatocellular Carcinoma in Patients with HBV-HDV Infection
Federico Costante, Leonardo Stella, Francesco Santopaolo, Antonio Gasbarrini, Maurizio Pompili, Tarik Asselah & Francesca Romana Ponziani
Pages: 713-724
Published online: 25 Apr 2023
AbstractforMolecular and Clinical Features of Hepatocellular Carcinoma in Patients with HBV-HDV Infection | Full Text | References | PDF (3.1 MB) | EPUB
  • 383 Views
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ORIGINAL RESEARCH

Article
Outcomes of National Survey of the Practice of Hepatocellular Carcinoma Surveillance
Robert A Scott, Timothy J S Cross, Christopher Clarke, Shahid A Khan, Stephen D Ryder, James Franklin & Aloysious D Aravinthan
Pages: 725-731
Published online: 29 Apr 2023
AbstractforOutcomes of National Survey of the Practice of Hepatocellular Carcinoma Surveillance | Full Text | References | PDF (1.6 MB) | EPUB
  • 240 Views
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REVIEW

Review
Current Advances in the Treatment of Fibrolamellar Carcinoma of Liver
Jyotsna Gummadi, Xin Wang & Changqing Xie
Pages: 745-752
Published online: 15 May 2023
AbstractforCurrent Advances in the Treatment of Fibrolamellar Carcinoma of Liver | Full Text | References | PDF (421.7 KB) | EPUB
  • 322 Views
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Review
Clinical Results, Risk Factors, and Future Directions of Ultrasound-Guided Percutaneous Microwave Ablation for Hepatocellular Carcinoma
Tian-Tian Dong, Lan Wang, Ming Li, Ci Yin, Yuan-Yuan Li & Fang Nie
Pages: 733-743
Published online: 15 May 2023
AbstractforClinical Results, Risk Factors, and Future Directions of Ultrasound-Guided Percutaneous Microwave Ablation for Hepatocellular Carcinoma | Full Text | References | PDF (521.3 KB) | EPUB
  • 209 Views
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ORIGINAL RESEARCH

Article
Clinical Benefits of Neoadjuvant Radiotherapy on the Postoperative Recurrence of Centrally Located Hepatocellular Carcinoma: A Real-World Evidence Based on Phase II Clinical Trial
Changcheng Tao, Fan Wu, Hongwei Wang, Liming Wang, Yue Liu, Anke Wu, Linlin Zheng, Yaru Wang, Bo Chen, Weiqi Rong & Jianxiong Wu
Pages: 753-764
Published online: 16 May 2023
AbstractforClinical Benefits of Neoadjuvant Radiotherapy on the Postoperative Recurrence of Centrally Located Hepatocellular Carcinoma: A Real-World Evidence Based on Phase II Clinical Trial | Full Text | References | PDF (3.7 MB) | EPUB
  • 193 Views
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Article
Screening and Verification of Key Ubiquitination Genes Related to Immune Infiltration in Stage III/IV Hepatocellular Carcinoma
Yuhong Tang, Jun Cao, Rui Peng, Xingkang Mao, Bingbing Su, Hao Tang, Daoyuan Tu, Jie Zhou, Guoqing Jiang, Shengjie Jin, Qian Wang, Chen Zhang, Renjie Liu, Chi Zhang & Dousheng Bai
Pages: 765-781
Published online: 22 May 2023
AbstractforScreening and Verification of Key Ubiquitination Genes Related to Immune Infiltration in Stage III/IV Hepatocellular Carcinoma | Full Text | References | PDF (15.9 MB) | EPUB
  • 201 Views
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Article
Detection of sFas, sCD137, and IL-27 Cytokines as Potential Biomarkers for Hepatocellular Carcinoma Diagnosis
Xuan-Hai Do, Mai Thi Le, Thu Huyen Nguyen, Thanh Thien Le, Xuan-Hung Nguyen, Thanh Binh Mai, Thi My Nhung Hoang & Uyen Thi Trang Than
Pages: 783-793
Published online: 26 May 2023
AbstractforDetection of sFas, sCD137, and IL-27 Cytokines as Potential Biomarkers for Hepatocellular Carcinoma Diagnosis | Full Text | References | PDF (3.3 MB) | EPUB
  • 323 Views
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Article
Safety and Efficacy of Drug-Eluting Bead Transarterial Chemoembolization Combined with Lenvatinib and Anti-PD-1 Antibodies for Unresectable Hepatocellular Carcinoma: A Retrospective Analysis
Shao-Jie Wu, Dan-Dan Ruan, Qiu-Yan Wu, Yi Tang, Jian-Hui Zhang, Sen-Lin Cai, Yan-Feng Zhou, Jie-Wei Luo & Zhu-Ting Fang
Pages: 807-820
Published online: 02 Jun 2023
AbstractforSafety and Efficacy of Drug-Eluting Bead Transarterial Chemoembolization Combined with Lenvatinib and Anti-PD-1 Antibodies for Unresectable Hepatocellular Carcinoma: A Retrospective Analysis | Full Text | References | PDF (2.6 MB) | EPUB
  • 268 Views
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Article
Radiomics Based on Dynamic Contrast-Enhanced Magnetic Resonance Imaging in Preoperative Differentiation of Combined Hepatocellular-Cholangiocarcinoma from Hepatocellular Carcinoma: A Multi-Center Study
Le Guo, Xijun Li, Chao Zhang, Yang Xu, Lujun Han & Ling Zhang
Pages: 795-806
Published online: 02 Jun 2023
AbstractforRadiomics Based on Dynamic Contrast-Enhanced Magnetic Resonance Imaging in Preoperative Differentiation of Combined Hepatocellular-Cholangiocarcinoma from Hepatocellular Carcinoma: A Multi-Center Study | Full Text | References | PDF (2.5 MB) | EPUB
  • 182 Views
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Article
Prognostic Significance of Hemoglobin, Albumin, Lymphocyte and Platelet (HALP) Score in Hepatocellular Carcinoma
Jing Zhou & Daofeng Yang
Pages: 821-831
Published online: 02 Jun 2023
AbstractforPrognostic Significance of Hemoglobin, Albumin, Lymphocyte and Platelet (HALP) Score in Hepatocellular Carcinoma | Full Text | References | PDF (4.3 MB) | EPUB
  • 183 Views
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Article
Clinicopathological Features of Hepatocellular Carcinoma with Metabolic Risk Factors
Lei Sun, Hong Zhao, Xiao-Yan Ding, Kun Yang, Gui-Shuang Wang, Jia-Min Chen, Xiao-Yi Han, Gang Wan, Liang Zhang, Xin-Gang Zhou, Xiang-Mei Chen, Peng Wang & Wen Xie
Pages: 833-846
Published online: 05 Jun 2023
AbstractforClinicopathological Features of Hepatocellular Carcinoma with Metabolic Risk Factors | Full Text | References | PDF (3 MB) | EPUB
  • 184 Views
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Article
Population Sensitive to Lenvatinib Plus Anti-PD-1 for Unresectable Hepatocellular Carcinoma Infected with Hepatitis B Virus
Xiujuan Chang, Shumin Yu, Jianzhi Pang, Wei Zhang, Huifang Kong, Jiagan Huang, Guojie Zhang, Huixin Zhang, Yueyue Gu, Yan Chen, Bin Yang, Jingping Liu & Zhen Zeng
Pages: 847-861
Published online: 06 Jun 2023
AbstractforPopulation Sensitive to Lenvatinib Plus Anti-PD-1 for Unresectable Hepatocellular Carcinoma Infected with Hepatitis B Virus | Full Text | References | PDF (7.1 MB) | EPUB
  • 180 Views
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Article
LINC00886 Facilitates Hepatocellular Carcinoma Tumorigenesis by Sequestering microRNA-409-3p and microRNA-214-5p
Lu Li, Rong Ai, Xiwei Yuan, Shiming Dong, Dandan Zhao, Xiaoye Sun, Tongguo Miao, Weiwei Guan, Peilin Guo, Songhao Yu & Yuemin Nan
Pages: 863-881
Published online: 08 Jun 2023
AbstractforLINC00886 Facilitates Hepatocellular Carcinoma Tumorigenesis by Sequestering microRNA-409-3p and microRNA-214-5p | Full Text | References | PDF (19.5 MB) | EPUB
  • 184 Views
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REVIEW

Review
Role of the HIF-1α/BNIP3 Signaling Pathway in Recurrent Hepatocellular Carcinoma and the Mechanism of Traditional Chinese Medicine
Sizhe Liu, Le Kang, Yagang Song & Mingsan Miao
Pages: 893-908
Published online: 08 Jun 2023
AbstractforRole of the HIF-1α/BNIP3 Signaling Pathway in Recurrent Hepatocellular Carcinoma and the Mechanism of Traditional Chinese Medicine | Full Text | References | PDF (3 MB) | EPUB
  • 250 Views
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ORIGINAL RESEARCH

Article
Safety and Efficacy of Transarterial Chemoembolization Combined with Tyrosine Kinase Inhibitor and Immune Checkpoint Inhibitors for Unresectable Hepatocellular Carcinoma: A Single Center Experience
Xian Pan, Shao-Jie Wu, Yi Tang, Yan-Feng Zhou, Jie-Wei Luo & Zhu-Ting Fang
Pages: 883-892
Published online: 09 Jun 2023
AbstractforSafety and Efficacy of Transarterial Chemoembolization Combined with Tyrosine Kinase Inhibitor and Immune Checkpoint Inhibitors for Unresectable Hepatocellular Carcinoma: A Single Center Experience | Full Text | References | PDF (455.5 KB) | EPUB
  • 198 Views
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Article
Novel Prognostic Nomogram to Predict Progression-Free Survival of Patients with Hepatocellular Carcinoma After Transarterial Chemoembolization
Dong Xi, Mengying Xu, Meiwen Han, Qianting Guan, Qinghao Guo, Fangfei Yan, Junxia Yao & Qin Ning
Pages: 909-920
Published online: 16 Jun 2023
AbstractforNovel Prognostic Nomogram to Predict Progression-Free Survival of Patients with Hepatocellular Carcinoma After Transarterial Chemoembolization | Full Text | References | PDF (1.7 MB) | EPUB
  • 145 Views
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Article
PD-L1 is Fascinating but IDO Needs Attention in Non-HCV and Non-HBV-Associated Hepatocellular Carcinoma Patients
Kashif Asghar, Shaarif Bashir, Iftikhar Ali Rana, Muhammad Abu Bakar, Asim Farooq, Muhammad Hassan, Zukhruf Asif, Mahnoor Afzal, Iqra Masood, Muhammad Ishaq, Muhammad Tahseen, Sundus Bilal, Shafqat Mehmood, Nosheen Kanwal, Islah Ud Din & Asif Loya
Pages: 921-934
Published online: 17 Jun 2023
AbstractforPD-L1 is Fascinating but IDO Needs Attention in Non-HCV and Non-HBV-Associated Hepatocellular Carcinoma Patients | Full Text | References | PDF (1.2 MB) | EPUB
  • 261 Views
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Article
Phellodendronoside A Exerts Anticancer Effects Depending on Inducing Apoptosis Through ROS/Nrf2/Notch Pathway and Modulating Metabolite Profiles in Hepatocellular Carcinoma
Yanpo Si, Chengcheng Hui, Tao Guo, Mengqi Liu, Xiaohui Chen, Chunhong Dong & Shuying Feng
Pages: 935-948
Published online: 20 Jun 2023
AbstractforPhellodendronoside A Exerts Anticancer Effects Depending on Inducing Apoptosis Through ROS/Nrf2/Notch Pathway and Modulating Metabolite Profiles in Hepatocellular Carcinoma | Full Text | References | PDF (9.7 MB) | EPUB
  • 214 Views
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Article
Simultaneous and Sequential Use of Molecular Targeted Agents Plus Immune Checkpoint Inhibitors for Advanced Hepatocellular Carcinoma: A Real-World Practice in China
Jing Li, Liang Huang, Chao Ge, Xingwu Zhu, Maixuan Qiu, Chaopan Chen, Shaohua Wei & Yiqun Yan
Pages: 949-958
Published online: 20 Jun 2023
AbstractforSimultaneous and Sequential Use of Molecular Targeted Agents Plus Immune Checkpoint Inhibitors for Advanced Hepatocellular Carcinoma: A Real-World Practice in China | Full Text | References | PDF (2.2 MB) | EPUB
  • 182 Views
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SHORT REPORT

Comparison of Ablation Volume Between Emprint® and Mimapro® Systems for Hepatocellular Carcinoma –A Preliminary Study
Toru Ishikawa, Iori Hasegawa, Hiroshi Hirosawa, Tsubasa Honmou, Nobuyuki Sakai, Takanori Igarashi, Shun Yamazaki, Takamasa Kobayashi, Toshifumi Sato, Akito Iwanaga, Tomoe Sano, Junji Yokoyama & Terasu Honma
Pages: 979-985
Published online: 22 Jun 2023
AbstractforComparison of Ablation Volume Between Emprint® and Mimapro® Systems for Hepatocellular Carcinoma –A Preliminary Study | Full Text | References | PDF (1 MB) | EPUB
  • 212 Views
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ORIGINAL RESEARCH

Article
An Analysis Regarding the Association Between the Nuclear Pore Complex (NPC) and Hepatocellular Carcinoma (HCC)
Pan Huang, Yi-dou Hu, Yuan-jie Liu, Jie-pin Li & Yong-hua Zhang
Pages: 959-978
Published online: 22 Jun 2023
AbstractforAn Analysis Regarding the Association Between the Nuclear Pore Complex (NPC) and Hepatocellular Carcinoma (HCC) | Full Text | References | PDF (16.3 MB) | EPUB
  • 208 Views
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Article
Outcomes of Radiation Segmentectomy for Hepatocellular Carcinoma in Patients with Non-Alcoholic Fatty Liver Disease versus Chronic Viral Hepatitis
Cynthia De la Garza-Ramos, S Ali Montazeri, Kaitlyn R Musto, Melissa D Kapp, Andrew R Lewis, Gregory Frey, Ricardo Paz-Fumagalli, Sumera Ilyas, Denise M Harnois, Umair Majeed, Tushar Patel & Beau Toskich
Pages: 987-996
Published online: 23 Jun 2023
AbstractforOutcomes of Radiation Segmentectomy for Hepatocellular Carcinoma in Patients with Non-Alcoholic Fatty Liver Disease versus Chronic Viral Hepatitis | Full Text | References | PDF (2.1 MB) | EPUB
  • 216 Views
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Article
Effect of Different Liver Resection Modalities on the Prognosis of Patients with Hepatocellular Carcinoma on the Left Lateral Lobe
Jianwei Liu, Minmin Sun, Kunpeng Fang, Jie Wang, Bowen Ma, Li Song, Ting Liu, Ming Tang, Kui Wang & Yong Xia
Pages: 997-1007
Published online: 28 Jun 2023
AbstractforEffect of Different Liver Resection Modalities on the Prognosis of Patients with Hepatocellular Carcinoma on the Left Lateral Lobe | Full Text | References | PDF (566.6 KB) | EPUB
  • 168 Views
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Article
Construction and Validation of TACE Therapeutic Efficacy by ALR Score and Nomogram: A Large, Multicenter Study
Han Li, Lu Guo, Ke Su, Changlun Li, Yi Jiang, Pan Wang, Jiali Chen, Zhenying Wu, Ke Xu, Tao Gu, Hao Zeng, Kun He, Hao Chi, Wenxi Zhao, Lei Han & Yunwei Han
Pages: 1009-1017
Published online: 29 Jun 2023
AbstractforConstruction and Validation of TACE Therapeutic Efficacy by ALR Score and Nomogram: A Large, Multicenter Study | Full Text | References | PDF (3.4 MB) | EPUB
  • 193 Views
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Article
LncRNA MEG3 Inhibits Tumor Progression by Modulating Macrophage Phenotypic Polarization via miR-145-5p/DAB2 Axis in Hepatocellular Carcinoma
Qing Wei, Guoman Liu, Zihua Huang, Yanyan Huang, Lizheng Huang, Zheng Huang, Xianjian Wu, Huamei Wei & Jian Pu
Pages: 1019-1035
Published online: 05 Jul 2023
AbstractforLncRNA MEG3 Inhibits Tumor Progression by Modulating Macrophage Phenotypic Polarization via miR-145-5p/DAB2 Axis in Hepatocellular Carcinoma | Full Text | References | PDF (11.7 MB) | EPUB
  • 299 Views
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Article
The Predictive Role of Inflammatory Biomarkers for Treatment Response and Progression-Free Survival in Patients with Hepatocellular Carcinoma Receiving Hepatic Arterial Infusion Chemotherapy with FOLFOX Regimen: A Preliminary Study
Yang Zhao, Jun Liu, Zhengping Xiong, Shanzhi Gu & Xibin Xia
Pages: 1037-1049
Published online: 08 Jul 2023
AbstractforThe Predictive Role of Inflammatory Biomarkers for Treatment Response and Progression-Free Survival in Patients with Hepatocellular Carcinoma Receiving Hepatic Arterial Infusion Chemotherapy with FOLFOX Regimen: A Preliminary Study | Full Text | References | PDF (3.1 MB) | EPUB
  • 187 Views
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Article
Infiltration of a Unique CD8+CD274+ Cell Subgroup in Hepatocellular Carcinoma is Associated with Poor Clinical Outcomes
Yong Zhang, Kaisa Cui, Yaoxiang Yang, Bingxin Liu, Minzheng Zhu, Hanqing Chen, Chong Zhao, Youlian Zhou & Yuqiang Nie
Pages: 1051-1067
Published online: 08 Jul 2023
AbstractforInfiltration of a Unique CD8+CD274+ Cell Subgroup in Hepatocellular Carcinoma is Associated with Poor Clinical Outcomes | Full Text | References | PDF (14.7 MB) | EPUB
  • 225 Views
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REVIEW

Review
Application and Resistance Mechanisms of Lenvatinib in Patients with Advanced Hepatocellular Carcinoma
Meng Tao, Jing Han, Juanyi Shi, Hao Liao, Kai Wen, Weidong Wang, Sintim Mui, Huoming Li, Yongcong Yan & Zhiyu Xiao
Pages: 1069-1083
Published online: 10 Jul 2023
AbstractforApplication and Resistance Mechanisms of Lenvatinib in Patients with Advanced Hepatocellular Carcinoma | Full Text | References | PDF (2.6 MB) | EPUB
  • 465 Views
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ORIGINAL RESEARCH

Article
The Long Non-Coding RNA AC006329.1 Facilitates Hepatocellular Carcinoma Progression and Metastasis by Regulating miR-127-5p/SHC3/ERK Axis
Xiang Xu Kong, Xiao Yang, Wang Jie Jiang, De Ming Zhu & Lian Bao Kong
Pages: 1085-1103
Published online: 17 Jul 2023
AbstractforThe Long Non-Coding RNA AC006329.1 Facilitates Hepatocellular Carcinoma Progression and Metastasis by Regulating miR-127-5p/SHC3/ERK Axis | Full Text | References | PDF (16.1 MB) | EPUB
  • 166 Views
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REVIEW

Review
Promising Novel Biomarkers for Hepatocellular Carcinoma: Diagnostic and Prognostic Insights
James Yu, Robin Park & Richard Kim
Pages: 1105-1127
Published online: 18 Jul 2023
AbstractforPromising Novel Biomarkers for Hepatocellular Carcinoma: Diagnostic and Prognostic Insights | Full Text | References | PDF (722.8 KB) | EPUB
  • 433 Views
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ORIGINAL RESEARCH

Article
Effects of Clinical and Tumor Characteristics on Survival in Patients with Hepatocellular Carcinoma with Bone Metastasis
Muhammet Ozer, Suleyman Yasin Goksu, Rick Y Lin, Ruveyda Ayasun, Doga Kahramangil, Sherise C Rogers, Jesus C Fabregas, Brian H Ramnaraign, Thomas J George, Michael Feely, Roniel Cabrera, Sergio Duarte, Ali Zarrinpar & Ilyas Sahin
Pages: 1129-1141
Published online: 19 Jul 2023
AbstractforEffects of Clinical and Tumor Characteristics on Survival in Patients with Hepatocellular Carcinoma with Bone Metastasis | Full Text | References | PDF (859.2 KB) | EPUB
  • 253 Views
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Article
Estimating Microvascular Invasion in Patients with Resectable Multinodular Hepatocellular Carcinoma by Using Preoperative Contrast-Enhanced MRI: Establishment and Validation of a Risk Score
Fei Wu, Haitao Sun, Zhang Shi, Changwu Zhou, Peng Huang, Yuyao Xiao, Chun Yang & Mengsu Zeng
Pages: 1143-1156
Published online: 20 Jul 2023
AbstractforEstimating Microvascular Invasion in Patients with Resectable Multinodular Hepatocellular Carcinoma by Using Preoperative Contrast-Enhanced MRI: Establishment and Validation of a Risk Score | Full Text | References | PDF (3.1 MB) | EPUB
  • 165 Views
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Article
Laparoscopic Hepatectomy versus Open Hepatectomy After Conversion Therapy Using Transarterial Chemoembolization or Hepatic Arterial Infusion Chemotherapy for Patients with Initially Unresectable Hepatocellular Carcinoma
Zhenyun Yang, Zili Hu, Yizhen Fu, Dandan Hu, Zhongguo Zhou, Minshan Chen, Yangxun Pan & Yaojun Zhang
Pages: 1157-1167
Published online: 21 Jul 2023
AbstractforLaparoscopic Hepatectomy versus Open Hepatectomy After Conversion Therapy Using Transarterial Chemoembolization or Hepatic Arterial Infusion Chemotherapy for Patients with Initially Unresectable Hepatocellular Carcinoma | Full Text | References | PDF (1.7 MB) | EPUB
  • 169 Views
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Article
The Role of miR-1183: A Potential Suppressor in Hepatocellular Carcinoma via Regulating Splicing Factor SRSF1
Zhilu Yao, Ning Liu, Hui Lin & Yingqun Zhou
Pages: 1169-1180
Published online: 21 Jul 2023
AbstractforThe Role of miR-1183: A Potential Suppressor in Hepatocellular Carcinoma via Regulating Splicing Factor SRSF1 | Full Text | References | PDF (10.4 MB) | EPUB
  • 167 Views
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Article
Transarterial Chemoembolization Combined with Atezolizumab Plus Bevacizumab or Lenvatinib for Unresectable Hepatocellular Carcinoma: A Propensity Score Matched Study
Chenghao Zhao, Zhanwang Xiang, Mingan Li, Haofan Wang, Huan Liu, Huzheng Yan & Mingsheng Huang
Pages: 1195-1206
Published online: 25 Jul 2023
AbstractforTransarterial Chemoembolization Combined with Atezolizumab Plus Bevacizumab or Lenvatinib for Unresectable Hepatocellular Carcinoma: A Propensity Score Matched Study | Full Text | References | PDF (4.9 MB) | EPUB
  • 229 Views
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Article
Development and Validation of Novel Models Including Tumor Micronecrosis for Predicting the Postoperative Survival of Patients with Hepatocellular Carcinoma
Xuqi Sun, Yangyang Wang, Hongbin Ge, Cao Chen, Xu Han, Ke Sun, Meng Wang, Xiaobao Wei, Mao Ye, Qi Zhang & Tingbo Liang
Pages: 1181-1194
Published online: 25 Jul 2023
AbstractforDevelopment and Validation of Novel Models Including Tumor Micronecrosis for Predicting the Postoperative Survival of Patients with Hepatocellular Carcinoma | Full Text | References | PDF (7 MB) | EPUB
  • 179 Views
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CORRIGENDUM

Correction
Boron Neutron Capture Therapy Eliminates Radioresistant Liver Cancer Cells by Targeting DNA Damage and Repair Responses [Corrigendum]
Pages: 1207-1208
Published online: 26 Jul 2023
CitationforBoron Neutron Capture Therapy Eliminates Radioresistant Liver Cancer Cells by Targeting DNA Damage and Repair Responses [Corrigendum] | Full Text | PDF (1.4 MB) | EPUB
  • 126 Views
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ORIGINAL RESEARCH

Article
Hepatic Arterial Infusion Chemotherapy Plus Lenvatinib and Tislelizumab with or Without Transhepatic Arterial Embolization for Unresectable Hepatocellular Carcinoma with Portal Vein Tumor Thrombus and High Tumor Burden: A Multicenter Retrospective Study
Song Chen, Feng Shi, Zhiqiang Wu, Liguang Wang, Hongjie Cai, Ping Ma, Yuanmin Zhou, Qicong Mai, Fan Wang, Shuangyan Tang, Wenquan Zhuang, Jiaming Lai, Xiaoming Chen, Huanwei Chen & Wenbo Guo
Pages: 1209-1222
Published online: 27 Jul 2023
AbstractforHepatic Arterial Infusion Chemotherapy Plus Lenvatinib and Tislelizumab with or Without Transhepatic Arterial Embolization for Unresectable Hepatocellular Carcinoma with Portal Vein Tumor Thrombus and High Tumor Burden: A Multicenter Retrospective Study | Full Text | References | PDF (4.9 MB) | EPUB
  • 267 Views
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Article
Hispanic Individuals are Underrepresented in Phase III Clinical Trials for Advanced Liver Cancer in the United States
Cecilia Monge, J Alberto Maldonado, Katherine A McGlynn & Tim F Greten
Pages: 1223-1235
Published online: 27 Jul 2023
AbstractforHispanic Individuals are Underrepresented in Phase III Clinical Trials for Advanced Liver Cancer in the United States | Full Text | References | PDF (6.6 MB) | EPUB
  • 205 Views
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Article
A Positive Feedback Loop of lncRNA HOXD-AS2 and SMYD3 Facilitates Hepatocellular Carcinoma Progression via the MEK/ERK Pathway
Jin Sun, Yingnan Li, Mengjiao Shi, Hongwei Tian, Jun Li, Kai Zhu, Ying Guo, Yanhua Mu, Jing Geng & Zongfang Li
Pages: 1237-1256
Published online: 27 Jul 2023
AbstractforA Positive Feedback Loop of lncRNA HOXD-AS2 and SMYD3 Facilitates Hepatocellular Carcinoma Progression via the MEK/ERK Pathway | Full Text | References | PDF (17.7 MB) | EPUB
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Article
PD-1 Inhibitors Combined with Antiangiogenic Therapy with or Without Transarterial Chemoembolization in the Treatment of Hepatocellular Carcinoma: A Propensity Matching Analysis
Han Li, Ke Su, Lu Guo, Yi Jiang, Ke Xu, Tao Gu, Jiali Chen, Zhenying Wu, Pan Wang, Xi Zhang, Yushan Yan, Siyuan Li, Xue Wu, Lei Han, Kun He, Lianbin Wen, Bo Li & Yunwei Han
Pages: 1257-1266
Published online: 29 Jul 2023
AbstractforPD-1 Inhibitors Combined with Antiangiogenic Therapy with or Without Transarterial Chemoembolization in the Treatment of Hepatocellular Carcinoma: A Propensity Matching Analysis | Full Text | References | PDF (2.7 MB) | EPUB
  • 180 Views
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Article
T-Lymphocyte Gene-Regulated CCL5 and Its Association with Extrahepatic Metastasis in Hepatocellular Carcinoma
Guoping Dong, Fangying Fan, Yao He, Yanchun Luo, Jie Yu & Ping Liang
Pages: 1267-1279
Published online: 02 Aug 2023
AbstractforT-Lymphocyte Gene-Regulated CCL5 and Its Association with Extrahepatic Metastasis in Hepatocellular Carcinoma | Full Text | References | PDF (5.8 MB) | EPUB
  • 170 Views
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Article
TRIM55 Promotes Proliferation of Hepatocellular Carcinoma Through Stabilizing TRIP6 to Activate Wnt/β-Catenin Signaling
Xun Lu, Yue Yuan, Ning Cai, Dean Rao, Min Chen, Xiaoping Chen, Bixiang Zhang, Huifang Liang & Lei Zhang
Pages: 1281-1293
Published online: 03 Aug 2023
AbstractforTRIM55 Promotes Proliferation of Hepatocellular Carcinoma Through Stabilizing TRIP6 to Activate Wnt/β-Catenin Signaling | Full Text | References | PDF (10.8 MB) | EPUB
  • 180 Views
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Article
Integration of Multimodal Computed Tomography Radiomic Features of Primary Tumors and the Spleen to Predict Early Recurrence in Patients with Postoperative Adjuvant Transarterial Chemoembolization
Cong Chen, Jian Liu, Zhuxin Gu, Yanjun Sun, Wenwu Lu, Xiaokan Liu, Kang Chen, Tianzhi Ma, Suming Zhao & Hui Zhao
Pages: 1295-1308
Published online: 08 Aug 2023
AbstractforIntegration of Multimodal Computed Tomography Radiomic Features of Primary Tumors and the Spleen to Predict Early Recurrence in Patients with Postoperative Adjuvant Transarterial Chemoembolization | Full Text | References | PDF (7.8 MB) | EPUB
  • 189 Views
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Article
Pan-Cancer Profiling and Digital Pathology Analysis Reveal Negative Prognostic Biomarker ZPR1 Associated with Immune Infiltration and Treatment Response in Hepatocellular Carcinoma
Lian He, Yusai Xie, Yusong Qiu & Yong Zhang
Pages: 1309-1325
Published online: 09 Aug 2023
AbstractforPan-Cancer Profiling and Digital Pathology Analysis Reveal Negative Prognostic Biomarker ZPR1 Associated with Immune Infiltration and Treatment Response in Hepatocellular Carcinoma | Full Text | References | PDF (14 MB) | EPUB
  • 226 Views
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Article
Downregulated Acetyl-CoA Acyltransferase 2 Promoted the Progression of Hepatocellular Carcinoma and Participated in the Formation of Immunosuppressive Microenvironment
Dehai Wu, Guanqun Liao, Yuanfei Yao, Lining Huang, Bowen Dong, Yong Ma & Guangchao Yang
Pages: 1327-1339
Published online: 09 Aug 2023
AbstractforDownregulated Acetyl-CoA Acyltransferase 2 Promoted the Progression of Hepatocellular Carcinoma and Participated in the Formation of Immunosuppressive Microenvironment | Full Text | References | PDF (10.7 MB) | EPUB
  • 216 Views
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Article
Prognosis of Patients with Hepatocellular Carcinoma Treated with Transarterial Chemoembolization(MC-hccAI 001): Development and Validation of the ALFP Score
Baocuo Gong, Xuewen Wang, Wanting Guo, Hongyi Yang, Yanhong Shi, Yaying Chen, Simiao Gao, Jialin Chen, Lifang Liu, Linbin Lu, Xiong Chen & On behalf of Fujian HCC-biomarker Study Group
Pages: 1341-1351
Published online: 11 Aug 2023
AbstractforPrognosis of Patients with Hepatocellular Carcinoma Treated with Transarterial Chemoembolization(MC-hccAI 001): Development and Validation of the ALFP Score | Full Text | References | PDF (4.3 MB) | EPUB
  • 175 Views
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Article
Sarcopenia Imperils Postoperative Long-Term Survival in HCC Patients with Metabolic Dysfunction-Associated Fatty Liver Disease: A Propensity Score Matching Analysis
Qingyan Kong, Mengshi Yi, Fei Teng, Hang Li & Zheyu Chen
Pages: 1367-1377
Published online: 16 Aug 2023
AbstractforSarcopenia Imperils Postoperative Long-Term Survival in HCC Patients with Metabolic Dysfunction-Associated Fatty Liver Disease: A Propensity Score Matching Analysis | Full Text | References | PDF (1.2 MB) | EPUB
  • 175 Views
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Article
Resection Margin Width Does Not Influence the Prognosis of Solitary Hepatocellular Carcinoma After Anatomic Resection: A Real-World Study from China
Qiao Ke, Zhiting Guo, Jian He, Zisen Lai, Fuli Xin, Yongyi Zeng, Lei Wang & Jingfeng Liu
Pages: 1353-1365
Published online: 16 Aug 2023
AbstractforResection Margin Width Does Not Influence the Prognosis of Solitary Hepatocellular Carcinoma After Anatomic Resection: A Real-World Study from China | Full Text | References | PDF (5.9 MB) | EPUB
  • 158 Views
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REVIEW

Review
Establishment and Clinical Application of the Nomogram Related to Risk or Prognosis of Hepatocellular Carcinoma: A Review
Xiangze Wang, Minghui Zhao, Chensheng Zhang, Haobo Chen, Xingyu Liu, Yang An, Lu Zhang & Xiangqian Guo
Pages: 1389-1398
Published online: 22 Aug 2023
AbstractforEstablishment and Clinical Application of the Nomogram Related to Risk or Prognosis of Hepatocellular Carcinoma: A Review | Full Text | References | PDF (6.1 MB) | EPUB
  • 233 Views
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CLINICAL TRIAL REPORT

Efficacy of Invariant Natural Killer T Cell Infusion Plus Transarterial Embolization vs Transarterial Embolization Alone for Hepatocellular Carcinoma Patients: A Phase 2 Randomized Clinical Trial
Jia Guo, Xuli Bao, Fuquan Liu, Jiang Guo, Yifan Wu, Fang Xiong & Jun Lu
Pages: 1379-1388
Published online: 21 Aug 2023
AbstractforEfficacy of Invariant Natural Killer T Cell Infusion Plus Transarterial Embolization vs Transarterial Embolization Alone for Hepatocellular Carcinoma Patients: A Phase 2 Randomized Clinical Trial | Full Text | References | PDF (1.5 MB) | EPUB
  • 163 Views
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ORIGINAL RESEARCH

Article
A Novel Nomogram for the Preoperative Prediction of Edmondson-Steiner Grade III-IV in Hepatocellular Carcinoma Patients
Zheyu Zhou, Shuya Cao, Chaobo Chen, Jun Chen, Xiaoliang Xu, Yang Liu, Qiaoyu Liu, Ke Wang, Bing Han & Yin Yin
Pages: 1399-1409
Published online: 23 Aug 2023
AbstractforA Novel Nomogram for the Preoperative Prediction of Edmondson-Steiner Grade III-IV in Hepatocellular Carcinoma Patients | Full Text | References | PDF (3.7 MB) | EPUB
  • 152 Views
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REVIEW

Review
Current Opinions on the Relationship Between CMTM Family and Hepatocellular Carcinoma
Yulin Pei, Zhengbao Zhang & Shengkui Tan
Pages: 1411-1422
Published online: 25 Aug 2023
AbstractforCurrent Opinions on the Relationship Between CMTM Family and Hepatocellular Carcinoma | Full Text | References | PDF (2.4 MB) | EPUB
  • 154 Views
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ORIGINAL RESEARCH

Article
Naples Prognostic Score is an Independent Prognostic Factor in Patients Undergoing Hepatectomy for Hepatocellular Carcinoma
Ya-Ming Xie, Wenfeng Lu, Jian Cheng, Mugen Dai, Si-Yu Liu, Dong-Dong Wang, Tian-Wei Fu, Tai-Wei Ye, Jun-Wei Liu, Cheng-Wu Zhang, Dong-Sheng Huang & Lei Liang
Pages: 1423-1433
Published online: 04 Sep 2023
AbstractforNaples Prognostic Score is an Independent Prognostic Factor in Patients Undergoing Hepatectomy for Hepatocellular Carcinoma | Full Text | References | PDF (2 MB) | EPUB
  • 145 Views
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Article
Efficacy and Safety of TACE Combined with Lenvatinib and PD-(L)1 Inhibitor in the Treatment of Unresectable Hepatocellular Carcinoma: A Retrospective Study
Hui Yang, Tiequan Yang, Guangpin Qiu & Jie Liu
Pages: 1435-1443
Published online: 05 Sep 2023
AbstractforEfficacy and Safety of TACE Combined with Lenvatinib and PD-(L)1 Inhibitor in the Treatment of Unresectable Hepatocellular Carcinoma: A Retrospective Study | Full Text | References | PDF (1.9 MB) | EPUB
  • 145 Views
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Article
Hepatic Arterial Infusion Chemotherapy Combined with Lenvatinib Plus Humanized Programmed Death Receptor-1 in Patients with High-Risk Advanced Hepatocellular Carcinoma: A Real-World Study
Xu Chang, Huiyong Wu, Shangkun Ning, Xinge Li, Yinfa Xie, Wenbo Shao & Jinming Yu
Pages: 1497-1509
Published online: 06 Sep 2023
AbstractforHepatic Arterial Infusion Chemotherapy Combined with Lenvatinib Plus Humanized Programmed Death Receptor-1 in Patients with High-Risk Advanced Hepatocellular Carcinoma: A Real-World Study | Full Text | References | PDF (4.3 MB) | EPUB
  • 155 Views
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REVIEW

Review
Immune-Based Combination Therapies for Advanced Hepatocellular Carcinoma
Riccardo Carloni, Simone Sabbioni, Alessandro Rizzo, Angela Dalia Ricci, Andrea Palloni, Cataldo Petrarota, Antonio Cusmai, Simona Tavolari, Gennaro Gadaleta-Caldarola & Giovanni Brandi
Pages: 1445-1463
Published online: 06 Sep 2023
AbstractforImmune-Based Combination Therapies for Advanced Hepatocellular Carcinoma | Full Text | References | PDF (1 MB) | EPUB
  • 260 Views
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ORIGINAL RESEARCH

Article
Adjuvant Lenvatinib Plus PD-1 Antibody for Hepatocellular Carcinoma with High Recurrence Risks After Hepatectomy: A Retrospective Landmark Analysis
Jingzhong Ouyang, Zhengzheng Wang, Kun Yuan, Yi Yang, Yanzhao Zhou, Qingjun Li, Nanmu Yang, Haitao Zhao, Hong Zhao & Jinxue Zhou
Pages: 1465-1477
Published online: 06 Sep 2023
AbstractforAdjuvant Lenvatinib Plus PD-1 Antibody for Hepatocellular Carcinoma with High Recurrence Risks After Hepatectomy: A Retrospective Landmark Analysis | Full Text | References | PDF (4.2 MB) | EPUB
  • 172 Views
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Article
N6-Methyladenosine-Modified ATP8B1-AS1 Exerts Oncogenic Roles in Hepatocellular Carcinoma via Epigenetically Activating MYC
Chuan Tan, Yanyan Huang, Zheng Huang, Yuanjia Ning, Lizheng Huang, Xianjian Wu, Yuan Lu, Huamei Wei & Jian Pu
Pages: 1479-1495
Published online: 06 Sep 2023
AbstractforN6-Methyladenosine-Modified ATP8B1-AS1 Exerts Oncogenic Roles in Hepatocellular Carcinoma via Epigenetically Activating MYC | Full Text | References | PDF (12.1 MB) | EPUB
  • 132 Views
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Article
Efficacy of TACE Combined with Lenvatinib Plus Sintilimab for Hepatocellular Carcinoma with Tumor Thrombus in the Inferior Vena Cava and/or Right Atrium
Shangkun Ning, Xinge Li, Xiangyu Ma, Jibing Liu & Xu Chang
Pages: 1511-1525
Published online: 13 Sep 2023
AbstractforEfficacy of TACE Combined with Lenvatinib Plus Sintilimab for Hepatocellular Carcinoma with Tumor Thrombus in the Inferior Vena Cava and/or Right Atrium | Full Text | References | PDF (5.5 MB) | EPUB
  • 159 Views
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EXPERT OPINION

Al-Hijamah (Prophetic Wet Cupping Therapy) is a Novel Adjuvant Treatment for Viral Hepatitis That Excretes Viral Particles and Excess Ferritin Percutaneously, Synergizes Pharmacotherapy, Enhances Antiviral Immunity and Helps Better HCC Prevention and Treatment: A Novel Evidence-Based Combination with Prophetic Medicine Remedies
Salah Mohamed El Sayed
Pages: 1527-1546
Published online: 13 Sep 2023
AbstractforAl-Hijamah (Prophetic Wet Cupping Therapy) is a Novel Adjuvant Treatment for Viral Hepatitis That Excretes Viral Particles and Excess Ferritin Percutaneously, Synergizes Pharmacotherapy, Enhances Antiviral Immunity and Helps Better HCC Prevention and Treatment: A Novel Evidence-Based Combination with Prophetic Medicine Remedies | Full Text | References | PDF (9.4 MB) | EPUB
  • 441 Views
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REVIEW

Review
Egyptian Society of Liver Cancer Recommendation Guidelines for the Management of Hepatocellular Carcinoma
Ashraf Omar, Ahmed Kaseb, Tamer Elbaz, Mohamed El-Kassas, Amr El Fouly, Abdel Fatah Hanno, Ahmed El Dorry, Ahmed Hosni, Amr Helmy, Amr S Saad, Ashwaq Alolayan, Basem Elsayed Eysa, Emad Hamada, Hamdy Azim, Hany Khattab, Hesham Elghazaly, Hesham Tawfik, Hisham Ayoub, Hussein Khaled, Ibtessam Saadeldin, Imam Waked, Eman MF Barakat, Mahmoud El Meteini, Mohamed Hamed Shaaban, Mohamed EzzElarab, Mohamed Fathy, Mohamed Shaker, Mohamed Sobhi, Mohamed Kamal Shaker, Mohamed ElGharib, Mohammed Abdullah, Mohesn Mokhtar, Mostafa Elshazli, Omar Mohamed Khaleil Heikal, Osama Hetta, Reda Mahmoud ElWakil, Sameh Abdel Wahab, Samir Shehata Eid, Yousri Rostom & On behalf of the Egyptian Liver Cancer Committee Study Group
Pages: 1547-1571
Published online: 18 Sep 2023
AbstractforEgyptian Society of Liver Cancer Recommendation Guidelines for the Management of Hepatocellular Carcinoma | Full Text | References | PDF (792 KB) | EPUB
  • 491 Views
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ORIGINAL RESEARCH

Article
Improved Survival in At-Risk Patients Undergoing Surveillance for Hepatocellular Carcinoma – A Nationwide Swedish Register-Based Study
Richard Thörn, Oskar Hemmingsson, Åsa Danielsson Borssén, Mårten Werner, Pontus Karling & Jonas Wixner
Pages: 1573-1586
Published online: 19 Sep 2023
AbstractforImproved Survival in At-Risk Patients Undergoing Surveillance for Hepatocellular Carcinoma – A Nationwide Swedish Register-Based Study | Full Text | References | PDF (771.1 KB) | EPUB
  • 157 Views
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Article
MRI Features for Predicting Microvascular Invasion and Postoperative Recurrence in Hepatocellular Carcinoma Without Peritumoral Hypointensity
Zhiyuan Chen, Xiaohuan Li, Yu Zhang, Yiming Yang, Yan Zhang, Dongjing Zhou, Yu Yang, Shuping Zhang & Yupin Liu
Pages: 1595-1608
Published online: 25 Sep 2023
AbstractforMRI Features for Predicting Microvascular Invasion and Postoperative Recurrence in Hepatocellular Carcinoma Without Peritumoral Hypointensity | Full Text | References | PDF (4.1 MB) | EPUB
  • 147 Views
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Article
Development and Validation of a Novel Prognosis Model Based on a Panel of Three Immunogenic Cell Death-Related Genes for Non-Cirrhotic Hepatocellular Carcinoma
Jiaojiao Gong, Renjie Yu, Xiaoxia Hu, Huating Luo, Qingzhu Gao, Yadi Li, Guili Tan, Haiying Luo & Bo Qin
Pages: 1609-1628
Published online: 25 Sep 2023
AbstractforDevelopment and Validation of a Novel Prognosis Model Based on a Panel of Three Immunogenic Cell Death-Related Genes for Non-Cirrhotic Hepatocellular Carcinoma | Full Text | References | PDF (17.8 MB) | EPUB
  • 163 Views
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CASE SERIES

Case Report
Modified Hepatic Arterial Infusion Chemotherapy Combined with Lenvatinib and Camrelizumab for Advanced HCC: Two Case Reports
Yuan Tian, Wenbiao Jin, Honghua Sun, Dehao Jin, Dongxu Kang, Zhiyu Li & Longzhen Piao
Pages: 1587-1593
Published online: 25 Sep 2023
AbstractforModified Hepatic Arterial Infusion Chemotherapy Combined with Lenvatinib and Camrelizumab for Advanced HCC: Two Case Reports | Full Text | References | PDF (4.1 MB) | EPUB
  • 129 Views
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ORIGINAL RESEARCH

Article
Transarterial Chemoembolization for Patients with Unresectable Hepatocellular Carcinoma with Child-Pugh B7
Jian-Qiang Jiang, Jin-Tao Huang, Bin-Yan Zhong, Wei-Dong Wang, Jun-Hui Sun, Qi Wang, Wen-Bin Ding, Cai-Fang Ni & Xiao-Li Zhu
Pages: 1629-1638
Published online: 26 Sep 2023
AbstractforTransarterial Chemoembolization for Patients with Unresectable Hepatocellular Carcinoma with Child-Pugh B7 | Full Text | References | PDF (3.6 MB) | EPUB
  • 152 Views
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Article
A Novel Gene Pair CSTF2/DPE2A Impacts Prognosis and Cell Cycle of Hepatocellular Carcinoma
Yangjin Huang, Jun Xu, Chunming Xie, Yuejuan Liao, Rong Lin, Yuan Zeng & Fujun Yu
Pages: 1639-1657
Published online: 28 Sep 2023
AbstractforA Novel Gene Pair CSTF2/DPE2A Impacts Prognosis and Cell Cycle of Hepatocellular Carcinoma | Full Text | References | PDF (13.3 MB) | EPUB
  • 136 Views
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Article
The Feasibility of Using Tri-Exponential Intra-Voxel Incoherent Motion DWI for Identifying the Microvascular Invasion in Hepatocellular Carcinoma
Yunfei Zhang, Ruofan Sheng, Chun Yang, Yongming Dai & Mengsu Zeng
Pages: 1659-1671
Published online: 29 Sep 2023
AbstractforThe Feasibility of Using Tri-Exponential Intra-Voxel Incoherent Motion DWI for Identifying the Microvascular Invasion in Hepatocellular Carcinoma | Full Text | References | PDF (8.8 MB) | EPUB
  • 179 Views
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REVIEW

Review
Safety and Efficacy of Atezolizumab and Bevacizumab Combination as a First Line Treatment of Advanced Hepatocellular Carcinoma
Valentina Zanuso, Angelo Pirozzi, Rita Balsano, Tiziana Pressiani & Lorenza Rimassa
Pages: 1689-1708
Published online: 02 Oct 2023
AbstractforSafety and Efficacy of Atezolizumab and Bevacizumab Combination as a First Line Treatment of Advanced Hepatocellular Carcinoma | Full Text | References | PDF (1.1 MB) | EPUB
  • 276 Views
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ORIGINAL RESEARCH

Article
Development and Validation of a Propionate Metabolism-Related Gene Signature for Prognostic Prediction of Hepatocellular Carcinoma
Jincheng Xiao, Jing Wang, Chaoqun Zhou & Junpeng Luo
Pages: 1673-1687
Published online: 02 Oct 2023
AbstractforDevelopment and Validation of a Propionate Metabolism-Related Gene Signature for Prognostic Prediction of Hepatocellular Carcinoma | Full Text | References | PDF (12.1 MB) | EPUB
  • 137 Views
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Article
Hepatectomy After Conversion Therapy with Hepatic Arterial Infusion Chemotherapy, Tyrosine Kinase Inhibitors and Anti-PD-1 Antibodies for Initially Unresectable Hepatocellular Carcinoma
Bingran Yu, Ning Zhang, Yun Feng, Yongfa Zhang, Ti Zhang & Lu Wang
Pages: 1709-1721
Published online: 04 Oct 2023
AbstractforHepatectomy After Conversion Therapy with Hepatic Arterial Infusion Chemotherapy, Tyrosine Kinase Inhibitors and Anti-PD-1 Antibodies for Initially Unresectable Hepatocellular Carcinoma | Full Text | References | PDF (1.1 MB) | EPUB
  • 127 Views
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REVIEW

Review
Transarterial Chemoembolization Plus Sorafenib versus Transarterial Chemoembolization Alone for Advanced Hepatocellular Carcinoma: An Umbrella Review of Meta-Analyses and Systematic Reviews
Jingxin Yan, Yonghao Wen, Manjun Deng, Bin Ye, Xinlian Liu & Lushun Zhang
Pages: 1723-1733
Published online: 05 Oct 2023
AbstractforTransarterial Chemoembolization Plus Sorafenib versus Transarterial Chemoembolization Alone for Advanced Hepatocellular Carcinoma: An Umbrella Review of Meta-Analyses and Systematic Reviews | Full Text | References | PDF (585.1 KB) | EPUB
  • 134 Views
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ORIGINAL RESEARCH

Article
Tyrosine Kinase Inhibitors Plus Anti-PD-1 Antibodies with Hepatic Arterial Infusion Chemotherapy or Transarterial Chemoembolization for Unresectable Hepatocellular Carcinoma
Bingran Yu, Ning Zhang, Yun Feng, Yongfa Zhang, Ti Zhang & Lu Wang
Pages: 1735-1748
Published online: 06 Oct 2023
AbstractforTyrosine Kinase Inhibitors Plus Anti-PD-1 Antibodies with Hepatic Arterial Infusion Chemotherapy or Transarterial Chemoembolization for Unresectable Hepatocellular Carcinoma | Full Text | References | PDF (1.5 MB) | EPUB
  • 112 Views
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Article
Expression of CKS2 in Hepatocellular Carcinoma: Correlation with Survival Outcomes and Immune Microenvironment
Renhou Zhi, Pengfei Hao, Weibin Li & Haoliang Zhao
Pages: 1767-1784
Published online: 09 Oct 2023
AbstractforExpression of CKS2 in Hepatocellular Carcinoma: Correlation with Survival Outcomes and Immune Microenvironment | Full Text | References | PDF (8 MB) | EPUB
  • 126 Views
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Article
Identification of a Novel Prognostic Signature Based on N-Linked Glycosylation and Its Correlation with Immunotherapy Response in Hepatocellular Carcinoma
Shusheng Lin, Yi Cao, Ke Zhu, Caini Yang, Xiangping Zhu, Honghua Zhang & Rui Zhang
Pages: 1749-1765
Published online: 09 Oct 2023
AbstractforIdentification of a Novel Prognostic Signature Based on N-Linked Glycosylation and Its Correlation with Immunotherapy Response in Hepatocellular Carcinoma | Full Text | References | PDF (15.9 MB) | EPUB
  • 155 Views
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Article
Associations Between Single Nucleotide Polymorphisms of Hypoxia-Related Genes and Capsule Formation in Hepatocellular Carcinoma
Shanshan Chen, Youjia Duan, Yongchao Zhang, Long Cheng, Liang Cai, Xiaopu Hou & Wei Li
Pages: 1785-1797
Published online: 10 Oct 2023
AbstractforAssociations Between Single Nucleotide Polymorphisms of Hypoxia-Related Genes and Capsule Formation in Hepatocellular Carcinoma | Full Text | References | PDF (4.1 MB) | EPUB
  • 174 Views
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Article
Transarterial Chemoembolization Plus Lenvatinib and PD-1 Inhibitors for Hepatocellular Carcinoma with Main Trunk Portal Vein Tumor Thrombus: A Multicenter Retrospective Study
Shu-Qun Li, Jun-Yi Wu, Jia-Yi Wu, Huang Xie, Jin-Hai Li, Zhen-Xin Zeng, Yang-Kai Fu, De-Yi Liu, Han Li, Wei-Zhao Chen, Jing-Yao Huang & Mao-Lin Yan
Pages: 1799-1811
Published online: 11 Oct 2023
AbstractforTransarterial Chemoembolization Plus Lenvatinib and PD-1 Inhibitors for Hepatocellular Carcinoma with Main Trunk Portal Vein Tumor Thrombus: A Multicenter Retrospective Study | Full Text | References | PDF (1.7 MB) | EPUB
  • 143 Views
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Article
Beta2-Microglobulin as Predictive Biomarkers in the Prognosis of Hepatocellular Carcinoma and Development of a New Nomogram
Qiumei Lin, Zongwei Jiang, Dan Mo, Fengfei Liu, Yuling Qin, Yihua Liang, Yuchen Cheng, Hao Huang & Min Fang
Pages: 1813-1825
Published online: 11 Oct 2023
AbstractforBeta2-Microglobulin as Predictive Biomarkers in the Prognosis of Hepatocellular Carcinoma and Development of a New Nomogram | Full Text | References | PDF (8.6 MB) | EPUB
  • 112 Views
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Article
Early Tumor Marker Response Predicts Treatment Outcomes in Patients with Unresectable Hepatocellular Carcinoma Receiving Combined Lenvatinib, Immune Checkpoint Inhibitors, and Transcatheter Arterial Chemoembolization Therapy
Meng-Chao Luo, Jia-Yi Wu, Jun-Yi Wu, Zhong-Tai Lin, Yi-Nan Li, Zhen-Xin Zeng, Shao-Ming Wei & Mao-Lin Yan
Pages: 1827-1837
Published online: 12 Oct 2023
AbstractforEarly Tumor Marker Response Predicts Treatment Outcomes in Patients with Unresectable Hepatocellular Carcinoma Receiving Combined Lenvatinib, Immune Checkpoint Inhibitors, and Transcatheter Arterial Chemoembolization Therapy | Full Text | References | PDF (4.1 MB) | EPUB
  • 131 Views
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Article
Efficacy and Safety of Microwave Ablation Assisted by Ultrasound Fusion Imaging for Primary and Secondary Liver Cancers with a Diameter of 3–7 Cm
Jing Yang, Shuang Liang, Huahui Liu, Cai Hu, Sainan Guan, Haiyu Kang, Erjiao Xu & Ronghua Yan
Pages: 1839-1848
Published online: 18 Oct 2023
AbstractforEfficacy and Safety of Microwave Ablation Assisted by Ultrasound Fusion Imaging for Primary and Secondary Liver Cancers with a Diameter of 3–7 Cm | Full Text | References | PDF (4 MB) | EPUB
  • 120 Views
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Article
Comparable Clinical Outcomes Between Transarterial Chemoembolization or Hepatic Arterial Infusion Chemotherapy Combined with Tyrosine Kinase Inhibitors and PD-1 Inhibitors in Unresectable Hepatocellular Carcinoma
Teng Long, Zhoutian Yang, Huilan Zeng, Weijie Wu, Zhiwen Hu, Zhenyun Yang, Dandan Hu, Zhongguo Zhou, Minshan Chen & Yaojun Zhang
Pages: 1849-1859
Published online: 20 Oct 2023
AbstractforComparable Clinical Outcomes Between Transarterial Chemoembolization or Hepatic Arterial Infusion Chemotherapy Combined with Tyrosine Kinase Inhibitors and PD-1 Inhibitors in Unresectable Hepatocellular Carcinoma | Full Text | References | PDF (3.4 MB) | EPUB
  • 134 Views
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Article
Hepatocellular Carcinoma with Radiological Progression: Lenvatinib Plus PD-1 Inhibitor Combined with Microwave Ablation and Synchronous Transarterial Chemoembolization
Qin Shi, Peng Huang, Zihan Zhang, Wen Zhang, Lingxiao Liu & Zhiping Yan
Pages: 1861-1871
Published online: 21 Oct 2023
AbstractforHepatocellular Carcinoma with Radiological Progression: Lenvatinib Plus PD-1 Inhibitor Combined with Microwave Ablation and Synchronous Transarterial Chemoembolization | Full Text | References | PDF (3.6 MB) | EPUB
  • 105 Views
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Article
Development and Validation of a Prediction Model for Hepatitis B Virus-Related Hepatocellular Carcinoma Patients Receiving Postoperative Adjuvant Transarterial Chemoembolization
Xinyue Tu, Jie Zhang, Minjun Li, Fei Lu, Ting Wang, Wenfeng Gong & Bangde Xiang
Pages: 1881-1895
Published online: 24 Oct 2023
AbstractforDevelopment and Validation of a Prediction Model for Hepatitis B Virus-Related Hepatocellular Carcinoma Patients Receiving Postoperative Adjuvant Transarterial Chemoembolization | Full Text | References | PDF (7.6 MB) | EPUB
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CASE SERIES

Case Report
The Extended Surgical Concepts for Hepatocellular Carcinoma in the Era of Immune Checkpoint Inhibitors
Hsiao-Mei Hsu, Hsin-I Tsai, Wei-Chen Lee, Chih-Chi Wang, Ming-Chin Yu, Shi-Ming Lin, Chun-Yen Lin, Chi-Huan Wu & Chao-Wei Lee
Pages: 1873-1880
Published online: 24 Oct 2023
AbstractforThe Extended Surgical Concepts for Hepatocellular Carcinoma in the Era of Immune Checkpoint Inhibitors | Full Text | References | PDF (5.4 MB) | EPUB
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ORIGINAL RESEARCH

Article
Efficacy and Safety of Transarterial Chemoembolization with a Three-Stage Mixed Chemoembolic Regimen for Large Unresectable Hepatocellular Carcinoma
Yanjie Yang, Nan Du, Jingqin Ma, Zhijie Peng, Bo Zhou, Jiaze Yu, Xin Zhou, Wen Zhang & Zhiping Yan
Pages: 1897-1910
Published online: 25 Oct 2023
AbstractforEfficacy and Safety of Transarterial Chemoembolization with a Three-Stage Mixed Chemoembolic Regimen for Large Unresectable Hepatocellular Carcinoma | Full Text | References | PDF (5.8 MB) | EPUB
  • 127 Views
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REVIEW

Review
Evidence to Date: Clinical Utility of Tremelimumab in the Treatment of Unresectable Hepatocellular Carcinoma
Zunirah Ahmed, Sunyoung S Lee, David W Victor 3rd & Sudha Kodali
Pages: 1911-1922
Published online: 27 Oct 2023
AbstractforEvidence to Date: Clinical Utility of Tremelimumab in the Treatment of Unresectable Hepatocellular Carcinoma | Full Text | References | PDF (1.4 MB) | EPUB
  • 179 Views
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ORIGINAL RESEARCH

Article
Treatment Outcomes in Patients with Advanced Fibrolamellar Hepatocellular Carcinoma Under Systemic Treatment: Analysis of Clinical Characteristics, Management, and Radiomics
Leonardo G Da Fonseca, Victor Junji Yamamoto, Mateus Trinconi Cunha, Giovanna Sawaya Torre, Raphael LC Araujo, Gilton Marques Fonseca, Andre Tsin Chih Chen, Aline Lopes Chagas, Paulo Herman, Venancio Avancini Ferreira Alves & Flair Jose Carrilho
Pages: 1923-1933
Published online: 01 Nov 2023
AbstractforTreatment Outcomes in Patients with Advanced Fibrolamellar Hepatocellular Carcinoma Under Systemic Treatment: Analysis of Clinical Characteristics, Management, and Radiomics | Full Text | References | PDF (2 MB) | EPUB
  • 136 Views
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Article
A Single-Step Immunocapture Assay to Quantify HCC Exosomes Using the Highly Sensitive Fluorescence Nanoparticle-Tracking Analysis
Ali Riza Koksal, Nergiz Ekmen, Yucel Aydin, Kelley Nunez, Tyler Sandow, Molly Delk, Martin Moehlen, Paul Thevenot, Ari Cohen & Srikanta Dash
Pages: 1935-1954
Published online: 01 Nov 2023
AbstractforA Single-Step Immunocapture Assay to Quantify HCC Exosomes Using the Highly Sensitive Fluorescence Nanoparticle-Tracking Analysis | Full Text | References | PDF (10.8 MB) | EPUB
  • 167 Views
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REVIEW

Review
Mechanisms of Resistance to Immunotherapy in Hepatocellular Carcinoma
Giulia Francesca Manfredi, Ciro Celsa, Chloe John, Charlotte Jones, Nicole Acuti, Bernhard Scheiner, Claudia Angela Maria Fulgenzi, James Korolewicz, Matthias Pinter, Alessandra Gennari, Francesco A Mauri, Mario Pirisi, Rosalba Minisini, Federica Vincenzi, Michela Burlone, Cristina Rigamonti, Matteo Donadon, Giuseppe Cabibbo, Antonio D’Alessio & David James Pinato
Pages: 1955-1971
Published online: 02 Nov 2023
AbstractforMechanisms of Resistance to Immunotherapy in Hepatocellular Carcinoma | Full Text | References | PDF (1.6 MB) | EPUB
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ORIGINAL RESEARCH

Article
Early C‐reactive Protein Kinetics Predict Response to Immune Checkpoint Blockade in Unresectable Hepatocellular Carcinoma
Qiuying Qin, Xiaoxuan Kou, Yuanyuan Zheng, Fei Zhou, Xiaoyong Zhang & Hongyan Liu
Pages: 2009-2019
Published online: 06 Nov 2023
AbstractforEarly C‐reactive Protein Kinetics Predict Response to Immune Checkpoint Blockade in Unresectable Hepatocellular Carcinoma | Full Text | References | PDF (2.2 MB) | EPUB
  • 148 Views
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Article
N6-Methyladenosine-Modified LEAWBIH Drives Hepatocellular Carcinoma Progression through Epigenetically Activating Wnt/β-Catenin Signaling
Huamei Wei, Lizheng Huang, Qi Lu, Zheng Huang, Yanyan Huang, Zuoming Xu, Wenchuan Li & Jian Pu
Pages: 1991-2007
Published online: 06 Nov 2023
AbstractforN6-Methyladenosine-Modified LEAWBIH Drives Hepatocellular Carcinoma Progression through Epigenetically Activating Wnt/β-Catenin Signaling | Full Text | References | PDF (13.3 MB) | EPUB
  • 92 Views
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Article
Immune Effects of Cryoablation in Woodchuck Hepatocellular Carcinoma
Michal Mauda-Havakuk, Natalie M Hawken, Joshua W Owen, Andrew S Mikhail, Matthew F Starost, Baktiar Karim, Paul G Wakim, Olga L Franco-Mahecha, Andrew L Lewis, William F Pritchard, John W Karanian & Bradford J Wood
Pages: 1973-1990
Published online: 06 Nov 2023
AbstractforImmune Effects of Cryoablation in Woodchuck Hepatocellular Carcinoma | Full Text | References | PDF (8.7 MB) | EPUB
  • 217 Views
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Article
AHSA1 Regulates Hepatocellular Carcinoma Progression via the TGF-β/Akt-Cyclin D1/CDK6 Pathway
Yanjun Gao, Yingge Li, Zheming Liu, Yi Dong, Siqi Yang, Bin Wu, Mengxia Xiao, Chen Chen, Yingmei Wen, Lei Chen, Haijuan Jiang & Yi Yao
Pages: 2021-2036
Published online: 07 Nov 2023
AbstractforAHSA1 Regulates Hepatocellular Carcinoma Progression via the TGF-β/Akt-Cyclin D1/CDK6 Pathway | Full Text | References | PDF (12.1 MB) | EPUB
  • 128 Views
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Article
Effectiveness and Safety of the PD-1 Inhibitor Lenvatinib Plus Radiotherapy in Patients with HCC with Main PVTT: Real-World Data from a Tertiary Centre
Guangxin Li, Ying Zhao, Keren Li, Shizhong Yang, Canhong Xiang, Jiyong Song, Yanmei Yang, Gong Li & Jiahong Dong
Pages: 2037-2048
Published online: 08 Nov 2023
AbstractforEffectiveness and Safety of the PD-1 Inhibitor Lenvatinib Plus Radiotherapy in Patients with HCC with Main PVTT: Real-World Data from a Tertiary Centre | Full Text | References | PDF (2.6 MB) | EPUB
  • 147 Views
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Article
Pretreatment Neutrophil-to-Lymphocyte Ratio as Prognostic Biomarkers in Patients with Unresectable Hepatocellular Carcinoma Treated with Hepatic Arterial Infusion Chemotherapy Combined with Lenvatinib and Camrelizumab
Yongqiang Xiao, Guoqing Zhu, Jin Xie, Laihui Luo, Wei Deng, Liucong Lin, Jiahao Tao, Zhigao Hu & Renfeng Shan
Pages: 2049-2058
Published online: 08 Nov 2023
AbstractforPretreatment Neutrophil-to-Lymphocyte Ratio as Prognostic Biomarkers in Patients with Unresectable Hepatocellular Carcinoma Treated with Hepatic Arterial Infusion Chemotherapy Combined with Lenvatinib and Camrelizumab | Full Text | References | PDF (3.3 MB) | EPUB
  • 150 Views
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Article
Prognostic Factors for Patients with Proliferative Hepatocellular Carcinoma After Liver Resection
Hong-Mei Li, Wei Huang, Chao Hu, Zi-Shu Zhang, Yu-Dong Xiao & Tian-Cheng Wang
Pages: 2059-2071
Published online: 19 Nov 2023
AbstractforPrognostic Factors for Patients with Proliferative Hepatocellular Carcinoma After Liver Resection | Full Text | References | PDF (4.6 MB) | EPUB
  • 117 Views
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REVIEW

Review
Tumor Microenvironment Composition and Related Therapy in Hepatocellular Carcinoma
Zishuai Li, Zihan Zhang, Letian Fang, Jiayi Zhao, Zheyun Niu, Hongsen Chen & Guangwen Cao
Pages: 2083-2099
Published online: 20 Nov 2023
AbstractforTumor Microenvironment Composition and Related Therapy in Hepatocellular Carcinoma | Full Text | References | PDF (2.7 MB) | EPUB
  • 238 Views
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ORIGINAL RESEARCH

Article
Prognosis Prediction of CRAFITY Score in HCC Undergoing TACE Combined with PD-(L)1 Inhibitors and Molecular Targeted Therapy
Ze-Xin Hu, Xiao-Yang Xu, Ze Wang, Jin-Tao Huang, Wan-Ci Li, Shuai Zhang, Jian Shen, Bin-Yan Zhong & Xiao-Li Zhu
Pages: 2073-2082
Published online: 20 Nov 2023
AbstractforPrognosis Prediction of CRAFITY Score in HCC Undergoing TACE Combined with PD-(L)1 Inhibitors and Molecular Targeted Therapy | Full Text | References | PDF (2 MB) | EPUB
  • 99 Views
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CORRIGENDUM

Correction
Egyptian Society of Liver Cancer Recommendation Guidelines for the Management of Hepatocellular Carcinoma [Corrigendum]
Pages: 2101-2102
Published online: 23 Nov 2023
CitationforEgyptian Society of Liver Cancer Recommendation Guidelines for the Management of Hepatocellular Carcinoma [Corrigendum] | Full Text | PDF (229.3 KB) | EPUB
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ORIGINAL RESEARCH

Article
Machine Learning-Based CEMRI Radiomics Integrating LI-RADS Features Achieves Optimal Evaluation of Hepatocellular Carcinoma Differentiation
Hai-Feng Liu, Yang Lu, Qing Wang, Yu-Jie Lu & Wei Xing
Pages: 2103-2115
Published online: 29 Nov 2023
AbstractforMachine Learning-Based CEMRI Radiomics Integrating LI-RADS Features Achieves Optimal Evaluation of Hepatocellular Carcinoma Differentiation | Full Text | References | PDF (6.1 MB) | EPUB
  • 125 Views
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Article
Tenofovir versus Entecavir on Outcomes of Hepatitis B Virus-Related Hepatocellular Carcinoma After FOLFOX-Hepatic Arterial Infusion Chemotherapy
Zhikai Zheng, Jiongliang Wang, Tianqing Wu, Minrui He, Juncheng Wang, Yangxun Pan, Jinbin Chen, Dandan Hu, Li Xu, Yaojun Zhang, Minshan Chen & Zhongguo Zhou
Pages: 2117-2132
Published online: 29 Nov 2023
AbstractforTenofovir versus Entecavir on Outcomes of Hepatitis B Virus-Related Hepatocellular Carcinoma After FOLFOX-Hepatic Arterial Infusion Chemotherapy | Full Text | References | PDF (6.1 MB) | EPUB
  • 115 Views
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Article
Systemic Inflammation Score Using Pretherapeutic Inflammatory Markers to Predict Prognosis for Hepatocellular Carcinoma Patients After Hepatic Arterial Infusion Chemotherapy
Tianqing Wu, Zhikai Zheng, Jiongliang Wang, Minrui He, Juncheng Wang, Yangxun Pan, Jinbin Chen, Dandan Hu, Yaojun Zhang, Li Xu, Minshan Chen & Zhongguo Zhou
Pages: 2133-2145
Published online: 30 Nov 2023
AbstractforSystemic Inflammation Score Using Pretherapeutic Inflammatory Markers to Predict Prognosis for Hepatocellular Carcinoma Patients After Hepatic Arterial Infusion Chemotherapy | Full Text | References | PDF (924.3 KB) | EPUB
  • 116 Views
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Article
Updates in Characteristics and Survival Rates of Hepatocellular Carcinoma in a Nationwide Cohort of Real-World US Patients, 2003–2021
Sally Tran, Biyao Zou, Leslie Kam, KeeSeok Lee, Daniel Q Huang, Linda Henry, Ramsey Cheung & Mindie H Nguyen
Pages: 2147-2158
Published online: 01 Dec 2023
AbstractforUpdates in Characteristics and Survival Rates of Hepatocellular Carcinoma in a Nationwide Cohort of Real-World US Patients, 2003–2021 | Full Text | References | PDF (1.2 MB) | EPUB
  • 127 Views
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CORRIGENDUM

Correction
The Feasibility of Using Tri-Exponential Intra-Voxel Incoherent Motion DWI for Identifying the Microvascular Invasion in Hepatocellular Carcinoma [Corrigendum]
Pages: 2159-2160
Published online: 01 Dec 2023
CitationforThe Feasibility of Using Tri-Exponential Intra-Voxel Incoherent Motion DWI for Identifying the Microvascular Invasion in Hepatocellular Carcinoma [Corrigendum] | Full Text | PDF (247.2 KB) | EPUB
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ORIGINAL RESEARCH

Article
Clinical Complete Response After Conversion Therapy for Unresectable Hepatocellular Carcinoma: Is Salvage Hepatectomy Necessary?
Jia-Yi Wu, Jun-Yi Wu, De-Yi Liu, Han Li, Shao-Wu Zhuang, Bin Li, Jian-Yin Zhou, Jing-Yao Huang, Zhi-Bo Zhang, Shu-Qun Li, Mao-Lin Yan & Yao-Dong Wang
Pages: 2161-2171
Published online: 04 Dec 2023
AbstractforClinical Complete Response After Conversion Therapy for Unresectable Hepatocellular Carcinoma: Is Salvage Hepatectomy Necessary? | Full Text | References | PDF (5.1 MB) | EPUB
  • 148 Views
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Article
miR-612 Enhances RSL3-Induced Ferroptosis of Hepatocellular Carcinoma Cells via Mevalonate Pathway
Kailin Xing, Xinyu Bian, Dongmin Shi, Shuangshuang Dong, Hongxin Zhou, Shuxiu Xiao, Jinjin Bai & Weizhong Wu
Pages: 2173-2185
Published online: 05 Dec 2023
AbstractformiR-612 Enhances RSL3-Induced Ferroptosis of Hepatocellular Carcinoma Cells via Mevalonate Pathway | Full Text | References | PDF (9.6 MB) | EPUB
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Article
Implanting Iodine-125 Seed Strand Inside the Portal Vein Stent: An Improved Approach to Endovascular Brachytherapy for Treatment of Patients with Hepatocellular Carcinoma and Main Portal Vein Tumor Thrombus
Liang Zhang, Jun Wang, Yang Li, Leina Hou, Jianguo Xia & Jialin Shen
Pages: 2187-2196
Published online: 05 Dec 2023
AbstractforImplanting Iodine-125 Seed Strand Inside the Portal Vein Stent: An Improved Approach to Endovascular Brachytherapy for Treatment of Patients with Hepatocellular Carcinoma and Main Portal Vein Tumor Thrombus | Full Text | References | PDF (3.5 MB) | EPUB
  • 108 Views
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Article
Liver Regeneration-Related Genes of Nontumor Liver Tissues Predict the Prognosis of Patients with Hepatocellular Carcinoma
Yanchao Xu, Yunzheng Li, Yanjun Lu, Weihong Wang, Zhaowu Lian, Zijie Wu, Binghua Li & Decai Yu
Pages: 2197-2209
Published online: 06 Dec 2023
AbstractforLiver Regeneration-Related Genes of Nontumor Liver Tissues Predict the Prognosis of Patients with Hepatocellular Carcinoma | Full Text | References | PDF (4.4 MB) | EPUB
  • 157 Views
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Article
Survival Prediction Model for Patients with Hepatocellular Carcinoma and Extrahepatic Metastasis Based on XGBoost Algorithm
Jihye Lim, Hyeon-Gi Jeon, Yeonjoo Seo, Moonjin Kim, Ja Un Moon & Se Hyun Cho
Pages: 2251-2263
Published online: 12 Dec 2023
AbstractforSurvival Prediction Model for Patients with Hepatocellular Carcinoma and Extrahepatic Metastasis Based on XGBoost Algorithm | Full Text | References | PDF (4 MB) | EPUB
  • 143 Views
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Article
Nomogram for Estimation of Acute Liver Failure Risk in Spontaneous Ruptured Hepatocellular Carcinoma
Zhi-Hao Zhao, Chao Jiang, Qing-Yuan Wu, Guo-Yue Lv & Meng Wang
Pages: 2223-2237
Published online: 12 Dec 2023
AbstractforNomogram for Estimation of Acute Liver Failure Risk in Spontaneous Ruptured Hepatocellular Carcinoma | Full Text | References | PDF (1.5 MB) | EPUB
  • 92 Views
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Article
The Safety and Efficacy of Hepatic Arterial Infusion Chemotherapy Combined with PD-(L)1 Inhibitors and Molecular Targeted Therapies for the Treatment of Intermediate and Advanced Hepatocellular Carcinoma Unsuitable for Transarterial Chemoembolization
Hao-Huan Tang, Ming-Qing Zhang, Zi-Chen Zhang, Chen Fan, Yong Jin & Wei-Dong Wang
Pages: 2211-2221
Published online: 12 Dec 2023
AbstractforThe Safety and Efficacy of Hepatic Arterial Infusion Chemotherapy Combined with PD-(L)1 Inhibitors and Molecular Targeted Therapies for the Treatment of Intermediate and Advanced Hepatocellular Carcinoma Unsuitable for Transarterial Chemoembolization | Full Text | References | PDF (2.9 MB) | EPUB
  • 109 Views
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Article
Development and Validation of a Prognostic Model for Transarterial Chemoembolization in Unresectable Hepatocellular Carcinoma Based on Preoperative Serum Prealbumin
Lin Xu, Dongxu Zhao, Pengcheng Tian, Jiaan Ding, Zhengyu Jiang, Guanyin Ni, Zhongheng Hou & Caifang Ni
Pages: 2239-2250
Published online: 12 Dec 2023
AbstractforDevelopment and Validation of a Prognostic Model for Transarterial Chemoembolization in Unresectable Hepatocellular Carcinoma Based on Preoperative Serum Prealbumin | Full Text | References | PDF (6 MB) | EPUB
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Article
Transarterial Chemoembolization Combined with Tyrosine Kinase Inhibitors Plus Immune Checkpoint Inhibitors for Advanced Hepatocellular Carcinoma: A Propensity Score Matching Analysis
Benjian Gao, Fengyi Yang, Dongning Zheng, Shuai Hu, Jie Liu, Hong Liu, Yongfa Liu, LinXin Liu, Rui Wang, Yi Zhao, Cheng Cui, Cheng Fang, Jin Yang, Song Su, Yunwei Han, Xiaoli Yang & Bo Li
Pages: 2265-2276
Published online: 12 Dec 2023
AbstractforTransarterial Chemoembolization Combined with Tyrosine Kinase Inhibitors Plus Immune Checkpoint Inhibitors for Advanced Hepatocellular Carcinoma: A Propensity Score Matching Analysis | Full Text | References | PDF (6.5 MB) | EPUB
  • 108 Views
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REVIEW

Review
An Overview of Traditional Chinese Medicine in the Treatment After Radical Resection of Hepatocellular Carcinoma
Yichen Peng, Xia Wu, Yurong Zhang, Yue Yin, Xianglin Chen, Ding Zheng & Jing Wang
Pages: 2305-2321
Published online: 17 Dec 2023
AbstractforAn Overview of Traditional Chinese Medicine in the Treatment After Radical Resection of Hepatocellular Carcinoma | Full Text | References | PDF (674.3 KB) | EPUB
  • 189 Views
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ORIGINAL RESEARCH

Article
Imaging-Derived Biomarkers Integrated with Clinical and Laboratory Values Predict Recurrence of Hepatocellular Carcinoma After Liver Transplantation
Thi Phuong Thao Hoang, Philipp Schindler, Nikolaus Börner, Max Masthoff, Mirjam Gerwing, Philippa von Beauvais, Enrico N De Toni, Christian M Lange, Jonel Trebicka, Haluk Morgül, Max Seidensticker, Jens Ricke, Andreas Pascher, Markus Guba, Michael Ingrisch, Moritz Wildgruber & Osman Öcal
Pages: 2277-2289
Published online: 17 Dec 2023
AbstractforImaging-Derived Biomarkers Integrated with Clinical and Laboratory Values Predict Recurrence of Hepatocellular Carcinoma After Liver Transplantation | Full Text | References | PDF (4.5 MB) | EPUB
  • 109 Views
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Article
Predicting T Cell-Inflamed Gene Expression Profile in Hepatocellular Carcinoma Based on Dynamic Contrast-Enhanced Ultrasound Radiomics
Yijie Wang, Weixiang Weng, Ruiming Liang, Qian Zhou, Hangtong Hu, Mingde Li, Lida Chen, Shuling Chen, Sui Peng, Ming Kuang, Han Xiao & Wei Wang
Pages: 2291-2303
Published online: 17 Dec 2023
AbstractforPredicting T Cell-Inflamed Gene Expression Profile in Hepatocellular Carcinoma Based on Dynamic Contrast-Enhanced Ultrasound Radiomics | Full Text | References | PDF (5 MB) | EPUB
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Article
Clinical-Radiological Characteristic for Predicting Ultra-Early Recurrence After Liver Resection in Solitary Hepatocellular Carcinoma Patients
Xinxin Wang, Yanyan Yu, Yuqing Tao, Yueqi Wang, Chunhui Zhang, Yali Cui & Yang Zhou
Pages: 2323-2335
Published online: 21 Dec 2023
AbstractforClinical-Radiological Characteristic for Predicting Ultra-Early Recurrence After Liver Resection in Solitary Hepatocellular Carcinoma Patients | Full Text | References | PDF (4.5 MB) | EPUB
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Article
Surgical Strategies Affect the Long-Term Prognosis of Patients with Hepatocellular Carcinoma Adjacent to the Left Branch of the Portal Vein
Shilei Bai, Xiaojing Shen, Jianwei Liu, Caixia Lu, Jie Wang, Liu Liu, Chunyan Wang, Huifeng Wang, Kai Liu, Yanfu Sun & Feng Xue
Pages: 2355-2366
Published online: 26 Feb 2024
AbstractforSurgical Strategies Affect the Long-Term Prognosis of Patients with Hepatocellular Carcinoma Adjacent to the Left Branch of the Portal Vein | Full Text | References | PDF (894.9 KB) | EPUB
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Article
Pretreatment Non-Invasive Biomarkers as Predictors to Estimate Portal Vein Tumor Thrombosis (PVTT) Risk and Long-Term Survival in HBV-Related Hepatocellular Carcinoma Patients Without PVTT
Bang Liu, Jia Liu, Xuan Mei, Zhi-Qiang Zhang, Jian Fang, Li-Li Zhou, Jiao-Long Zheng, Hai-Yan Lin, Xiu-Ling Zhu & Dong-Liang Li
Pages: 2367-2382
Published online: 27 Dec 2023
AbstractforPretreatment Non-Invasive Biomarkers as Predictors to Estimate Portal Vein Tumor Thrombosis (PVTT) Risk and Long-Term Survival in HBV-Related Hepatocellular Carcinoma Patients Without PVTT | Full Text | References | PDF (3.4 MB) | EPUB
  • 73 Views
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Article
Deciphering the Divergent Gene Expression Landscapes of m6A/m5C/m1A Methylation Regulators in Hepatocellular Carcinoma Through Single-Cell and Bulk RNA Transcriptomic Analysis
Hang-Tsung Liu, Cheng-Shyuan Rau, Yueh-Wei Liu, Ting-Min Hsieh, Chun-Ying Huang, Peng-Chen Chien, Hui-Ping Lin, Chia-Jung Wu, Pei-Chin Chuang & Ching-Hua Hsieh
Pages: 2383-2395
Published online: 27 Dec 2023
AbstractforDeciphering the Divergent Gene Expression Landscapes of m6A/m5C/m1A Methylation Regulators in Hepatocellular Carcinoma Through Single-Cell and Bulk RNA Transcriptomic Analysis | Full Text | References | PDF (13.6 MB) | EPUB
  • 115 Views
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Article
Pencil Beam Scanning Carbon Ion Radiotherapy for Hepatocellular Carcinoma
Wenna Zhang, Xin Cai, Jiayao Sun, Weiwei Wang, Jingfang Zhao, Qing Zhang, Guoliang Jiang & Zheng Wang
Pages: 2397-2409
Published online: 28 Dec 2023
AbstractforPencil Beam Scanning Carbon Ion Radiotherapy for Hepatocellular Carcinoma | Full Text | References | PDF (1.9 MB) | EPUB
  • 153 Views
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Article
Hepatitis B Virus-Encoded MicroRNA (HBV-miR-3) Inhibits FIH-1 Expression to Promote Tumor Angiogenesis in HBV-Related Hepatocellular Carcinoma
Han Chen, Dan Cao, Ning Han, Mingming Zhang, Wei Jiang, Xin Wang, Qinmin Zeng & Hong Tang
Pages: 2337-2353
Published online: 29 Dec 2023
AbstractforHepatitis B Virus-Encoded MicroRNA (HBV-miR-3) Inhibits FIH-1 Expression to Promote Tumor Angiogenesis in HBV-Related Hepatocellular Carcinoma | Full Text | References | PDF (10.8 MB) | EPUB
  • 115 Views
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