Epigenetics, Volume 18, Issue 1 (2023)

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Epigenetics, Volume 18, Issue 1 (2023)

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Research Paper

Article
Epigenetic control of the imprinted growth regulator Cdkn1c in cadmium-induced placental dysfunction
Mark D. Simmers, Kathleen M. Hudson, Marine Baptissart & Michael Cowley
Article: 2088173
Published online: 30 Jun 2022
AbstractforEpigenetic control of the imprinted growth regulator Cdkn1c in cadmium-induced placental dysfunction | Full Text | References | PDF (5 MB) | EPUB | Supplemental
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Open Access
Article
Functional study and epigenetic targets analyses of SIRT1 in intramuscular preadipocytes via ChIP-seq and mRNA-seq
Hongbiao Ran, Qiuya He, Yuting Han, Jikun Wang, Haibo Wang, Binglin Yue, Ming Zhang, Zhixin Chai, Xin Cai, Jincheng Zhong & Hui Wang
Article: 2135194
Published online: 20 Oct 2022
AbstractforFunctional study and epigenetic targets analyses of SIRT1 in intramuscular preadipocytes via ChIP-seq and mRNA-seq | Full Text | References | PDF (5.9 MB) | EPUB | Supplemental
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Open Access
Article
Uncertainty quantification of reference-based cellular deconvolution algorithms
Dorothea Seiler Vellame, Gemma Shireby, Ailsa MacCalman, Emma L Dempster, Joe Burrage, Tyler Gorrie-Stone, Leonard S Schalkwyk, Jonathan Mill & Eilis Hannon
Article: 2137659
Published online: 20 Dec 2022
AbstractforUncertainty quantification of reference-based cellular deconvolution algorithms | Full Text | References | PDF (1.9 MB) | EPUB | Supplemental
  • 1394 Views
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Open Access
Article
A comprehensive atlas of epigenetic regulators reveals tissue-specific epigenetic regulation patterns
Jilu Wang, Aiai Shi & Jie Lyu
Article: 2139067
Published online: 28 Oct 2022
AbstractforA comprehensive atlas of epigenetic regulators reveals tissue-specific epigenetic regulation patterns | Full Text | References | PDF (7.4 MB) | EPUB | Supplemental
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Open Access
Article
Multiple tissue-specific epigenetic alterations regulate persistent gene expression changes following developmental DES exposure in mouse reproductive tissues
Tanner B. Jefferson, Tianyuan Wang, Wendy N. Jefferson, Yin Li, Katherine J. Hamilton, Paul A. Wade, Carmen J. Williams & Kenneth S. Korach
Article: 2139986
Published online: 03 Nov 2022
AbstractforMultiple tissue-specific epigenetic alterations regulate persistent gene expression changes following developmental DES exposure in mouse reproductive tissues | Full Text | References | PDF (6.3 MB) | EPUB | Supplemental
  • 1522 Views
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Open Access
Article
Comparison of global DNA methylation analysis by whole genome bisulfite sequencing and the Infinium Mouse Methylation BeadChip using fresh and fresh-frozen mouse epidermis
Olivia Strunge Meyer, Mikkel Meyer Andersen, Claus Børsting, Niels Morling, Hans Christian Wulf, Peter Alshede Philipsen, Catharina Margrethe Lerche & Jeppe Dyrberg Andersen
Article: 2144574
Published online: 14 Nov 2022
AbstractforComparison of global DNA methylation analysis by whole genome bisulfite sequencing and the Infinium Mouse Methylation BeadChip using fresh and fresh-frozen mouse epidermis | Full Text | References | PDF (1.7 MB) | EPUB | Supplemental
  • 1581 Views
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Open Access
Article
CircRNF111 Contributes to Adipocyte Differentiation by Elevating PPARγ Expression via miR-27a-3p
Xuemei Shen, Jia Tang, Yongzhen Huang, Xianyong Lan, Chuzhao Lei & Hong Chen
Article: 2145058
Published online: 15 Nov 2022
AbstractforCircRNF111 Contributes to Adipocyte Differentiation by Elevating PPARγ Expression via miR-27a-3p | Full Text | References | PDF (4.5 MB) | EPUB
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Open Access

Brief Report

Brief Report
Contribution of miR-124 rs531564 polymorphism to the occurrence of congenital Zika syndrome
Julia A Gomes, Igor Araujo Vieira, Eduarda Sgarioni, Ana Cláudia P Terças-Tretell, Juliana H da Silva, Bethânia FR Ribeiro, Marcial F Galera, Thalita M de Oliveira, Maria Denise F Carvalho de Andrade, Isabella F Carvalho, Lavínia Schüler-Faccini & Fernanda SL Vianna
Article: 2145061
Published online: 21 Nov 2022
AbstractforContribution of miR-124 rs531564 polymorphism to the occurrence of congenital Zika syndrome | Full Text | References | PDF (1,007.8 KB) | EPUB | Supplemental
  • 1211 Views
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Open Access

Research Paper

Article
Sprouty4 is epigenetically upregulated in human colorectal cancer
Alexei J. Stuckel, Shuai Zeng, Zhen Lyu, Wei Zhang, Xu Zhang, Urszula Dougherty, Reba Mustafi, Tripti Khare, Qiong Zhang, Trupti Joshi, Marc Bissonnette & Sharad Khare
Article: 2145068
Published online: 16 Nov 2022
AbstractforSprouty4 is epigenetically upregulated in human colorectal cancer | Full Text | References | PDF (1.8 MB) | EPUB | Supplemental
  • 1448 Views
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Open Access
Article
Assessment of aberrant DNA methylation two years after paediatric critical illness: a pre-planned secondary analysis of the international PEPaNIC trial
Grégoire Coppens, Ilse Vanhorebeek, Ines Verlinden, Inge Derese, Pieter J Wouters, Koen F. Joosten, Sascha C. Verbruggen, Fabian Güiza & Greet Van den Berghe
Article: 2146966
Published online: 16 Nov 2022
AbstractforAssessment of aberrant DNA methylation two years after paediatric critical illness: a pre-planned secondary analysis of the international PEPaNIC trial | Full Text | References | PDF (1,001.1 KB) | EPUB | Supplemental
  • 1346 Views
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Open Access
Article
A key regulatory loop AK4P1/miR-375/SP1 in pancreatic adenocarcinoma
Wangjin Xu, Weiyang Lou & Linhang Mei
Article: 2148433
Published online: 07 Dec 2022
AbstractforA key regulatory loop AK4P1/miR-375/SP1 in pancreatic adenocarcinoma | Full Text | References | PDF (3.2 MB) | EPUB | Supplemental
  • 1250 Views
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Open Access

Review

Review
Circulating miRNAs in the first trimester and pregnancy complications: a systematic review
Anita Subramanian, Doria Weiss, Kate Nyhan, Andrew Dewan & Anne Marie Z. Jukic
Article: 2152615
Published online: 12 Dec 2022
AbstractforCirculating miRNAs in the first trimester and pregnancy complications: a systematic review | Full Text | References | PDF (303.6 KB) | EPUB | Supplemental
  • 2145 Views
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Open Access

Research Paper

Article
Exploration of genome-wide DNA methylation profiles in night shift workers
Paul Wackers, Martijn E. T. Dollé, Conny T.M. van Oostrom & Linda W.M. van Kerkhof
Article: 2152637
Published online: 01 Dec 2022
AbstractforExploration of genome-wide DNA methylation profiles in night shift workers | Full Text | References | PDF (5 MB) | EPUB | Supplemental
  • 1958 Views
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Open Access
Article
Childhood environment influences epigenetic age and methylation concordance of a CpG clock locus in British-Bangladeshi migrants
Reinhard Stöger, Minseung Choi, Khurshida Begum, Gregory Leeman, Richard D. Emes, Philippa Melamed & Gillian R. Bentley
Article: 2153511
Published online: 10 Dec 2022
AbstractforChildhood environment influences epigenetic age and methylation concordance of a CpG clock locus in British-Bangladeshi migrants | Full Text | References | PDF (604.1 KB) | EPUB | Supplemental
  • 1616 Views
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Open Access

Review

Review
Analysis approaches for the identification and prediction of N6-methyladenosine sites
Yuwei Yang, Zhiyu Liu, Junru Lu, Yuqing Sun, Yue Fu, Min Pan, Xueying Xie & Qinyu Ge
Article: 2158284
Published online: 23 Dec 2022
AbstractforAnalysis approaches for the identification and prediction of N6-methyladenosine sites | Full Text | References | PDF (2 MB) | EPUB
  • 2396 Views
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Open Access

Brief Report

Brief Report
Leukocyte DNA methylation in Alzheimer´s disease associated genes: replication of findings from neuronal cells
Ida K Karlsson, Alexander Ploner, Yunzhang Wang, Margaret Gatz, Nancy L Pedersen & Sara Hägg
Article: 2158285
Published online: 26 Dec 2022
AbstractforLeukocyte DNA methylation in Alzheimer´s disease associated genes: replication of findings from neuronal cells | Full Text | References | PDF (704.3 KB) | EPUB | Supplemental
  • 1627 Views
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Open Access

Research Paper

Article
m6A RNA methylation regulators predict prognosis and indicate characteristics of tumour microenvironment infiltration in acute myeloid leukaemia
Xinai Liao, Ling Chen, Jingru Liu, Haoran Hu, Diyu Hou, Ruolan You, Xiaoting Wang & Huifang Huang
Article: 2160134
Published online: 25 Dec 2022
Abstractform6A RNA methylation regulators predict prognosis and indicate characteristics of tumour microenvironment infiltration in acute myeloid leukaemia | Full Text | References | PDF (10.5 MB) | EPUB | Supplemental
  • 2040 Views
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Open Access
Article
Non-pathogenic microbiota accelerate age-related CpG Island methylation in colonic mucosa
Ang Sun, Pyounghwa Park, Lauren Cole, Himani Vaidya, Shinji Maegawa, Kelsey Keith, Gennaro Calendo, Jozef Madzo, Jaroslav Jelinek, Christian Jobin & Jean-Pierre J. Issa
Article: 2160568
Published online: 26 Dec 2022
AbstractforNon-pathogenic microbiota accelerate age-related CpG Island methylation in colonic mucosa | Full Text | References | PDF (2.4 MB) | EPUB | Supplemental
  • 1721 Views
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Open Access
Article
Comparison between indicine and taurine cattle DNA methylation reveals epigenetic variation associated to differences in morphological adaptive traits
E. Capra, B. Lazzari, M. Milanesi, G. P. Nogueira, J. f. Garcia, Y.T. Utsunomiya, P. Ajmone-Marsan & A. Stella
Article: 2163363
Published online: 04 Jan 2023
AbstractforComparison between indicine and taurine cattle DNA methylation reveals epigenetic variation associated to differences in morphological adaptive traits | Full Text | References | PDF (2.5 MB) | EPUB | Supplemental
  • 1715 Views
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Open Access
Article
Identification and comparison of m6A modifications in glioblastoma non-coding RNAs with MeRIP-seq and Nanopore dRNA-seq
Raulas Krusnauskas, Rytis Stakaitis, Giedrius Steponaitis, Kristian Almstrup & Paulina Vaitkiene
Article: 2163365
Published online: 03 Jan 2023
AbstractforIdentification and comparison of m6A modifications in glioblastoma non-coding RNAs with MeRIP-seq and Nanopore dRNA-seq | Full Text | References | PDF (2.2 MB) | EPUB | Supplemental
  • 4453 Views
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Open Access
Article
Associations of green and blue space exposure in pregnancy with epigenetic gestational age acceleration
Irene Marques, Susana Santos, Giulietta S. Monasso, Serena Fossati, Martine Vrijheid, Mark Nieuwenhuijsen, Vincent W. V. Jaddoe & Janine F. Felix
Article: 2165321
Published online: 11 Jan 2023
AbstractforAssociations of green and blue space exposure in pregnancy with epigenetic gestational age acceleration | Full Text | References | PDF (972.2 KB) | EPUB | Supplemental
  • 1757 Views
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Open Access

Review

Review
ΔNp63α-mediated epigenetic regulation in keratinocyte senescence
Linghan Kuang & Chenghua Li
Article: 2173931
Published online: 09 Feb 2023
AbstractforΔNp63α-mediated epigenetic regulation in keratinocyte senescence | Full Text | References | PDF (1.4 MB) | EPUB
  • 1584 Views
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Open Access

Research Paper

Article
Upregulation of KHDC1L promotes the proliferation and inhibits apoptosis in head and neck squamous cell carcinoma
Qi Zhang, Shuimei Luo, Yang Luo, Yiqiang Huang, Ziming Wang & Xianhe Xie
Article: 2175168
Published online: 03 Feb 2023
AbstractforUpregulation of KHDC1L promotes the proliferation and inhibits apoptosis in head and neck squamous cell carcinoma | Full Text | References | PDF (2.3 MB) | EPUB | Supplemental
  • 1771 Views
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Open Access
Article
Targeted epigenetic silencing of UCHL1 expression suppresses collagen-1 production in human lung epithelial cells
Dan-Dan Wu, Andy T. Y. Lau, Yan-Ming Xu, Marjan Reinders-Luinge, Mihaly Koncz, Antal Kiss, Wim Timens, Marianne G. Rots & Machteld N. Hylkema
Article: 2175522
Published online: 22 Feb 2023
AbstractforTargeted epigenetic silencing of UCHL1 expression suppresses collagen-1 production in human lung epithelial cells | Full Text | References | PDF (4.5 MB) | EPUB | Supplemental
  • 1544 Views
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Open Access
Article
Circ_0078607 increases platinum drug sensitivity via miR-196b-5p/GAS7 axis in ovarian cancer
Cheng Dai, Shi-Yuan Dai, Yan Gao, Ting Yan, Qi-Yin Zhou, Shi-jun Liu, Xuan Liu, Dan-Ni Deng, Dong-Hong Wang, Qing-Feng Qin & Dan Zi
Article: 2175565
Published online: 12 Mar 2023
AbstractforCirc_0078607 increases platinum drug sensitivity via miR-196b-5p/GAS7 axis in ovarian cancer | Full Text | References | PDF (4.1 MB) | EPUB
  • 1798 Views
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Open Access
Article
CircDHRS3 inhibits prostate cancer cell proliferation and metastasis through the circDHRS3/miR-421/MEIS2 axis
Xiyu Dai, Xinan Chen, Wensun Chen, Yuxi Ou, Yiling Chen, Siqi Wu, Quan Zhou, Chen Yang, Limin Zhang & Haowen Jiang
Article: 2178802
Published online: 25 Feb 2023
AbstractforCircDHRS3 inhibits prostate cancer cell proliferation and metastasis through the circDHRS3/miR-421/MEIS2 axis | Full Text | References | PDF (4.5 MB) | EPUB | Supplemental
  • 2760 Views
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Open Access
Article
Sex-based differences in placental DNA methylation profiles related to gestational age: an NIH ECHO meta-analysis
Catherine M. Bulka, Todd M. Everson, Amber A. Burt, Carmen J. Marsit, Margaret R. Karagas, Kristen E. Boyle, Sierra Niemiec, Katerina Kechris, Elizabeth J. Davidson, Ivana V. Yang, Jason I. Feinberg, Heather E. Volk, Christine Ladd-Acosta, Carrie V. Breton, T. Michael O’Shea, Rebecca C. Fry & on behalf of program collaborators for Environmental influences on Child Health Outcomes
Article: 2179726
Published online: 25 Feb 2023
AbstractforSex-based differences in placental DNA methylation profiles related to gestational age: an NIH ECHO meta-analysis | Full Text | References | PDF (4.4 MB) | EPUB | Supplemental
  • 2126 Views
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Open Access
Article
Comparative and integrative analysis of transcriptomic and epigenomic-wide DNA methylation changes in African American prostate cancer
Chad J. Creighton, Flora Zhang, Yiqun Zhang, Patricia Castro, Rong Hu, Md Islam, Somiranjan Ghosh, Michael Ittmann & Bernard Kwabi-Addo
Article: 2180585
Published online: 22 Feb 2023
AbstractforComparative and integrative analysis of transcriptomic and epigenomic-wide DNA methylation changes in African American prostate cancer | Full Text | References | PDF (5.7 MB) | EPUB
  • 2259 Views
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Open Access
Article
Crosstalk between m6A mRNAs and m6A circRNAs and the time-specific biogenesis of m6A circRNAs after OGD/R in primary neurons
Chi Zhang, Huan Jian, Shenghui Shang, Lu Lu, Yongfu Lou, Yi Kang, Hong Bai, Zheng Fu, Yigang Lv, Xiaohong Kong, Xueying Li, Shiqing Feng & Hengxing Zhou
Article: 2181575
Published online: 01 Mar 2023
AbstractforCrosstalk between m6A mRNAs and m6A circRNAs and the time-specific biogenesis of m6A circRNAs after OGD/R in primary neurons | Full Text | References | PDF (5.4 MB) | EPUB | Supplemental
  • 2144 Views
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Open Access
Article
Coordinated alternation of DNA methylation and alternative splicing of PBRM1 affect bovine sperm structure and motility
Chunhong Yang, Yao Xiao, Xiuge Wang, Xiaochao Wei, Jinpeng Wang, Yaping Gao, Qiang Jiang, Zhihua Ju, Yaran Zhang, Wenhao Liu, Ning Huang, Yanqin Li, Yundong Gao, Lingling Wang & Jinming Huang
Article: 2183339
Published online: 03 Mar 2023
AbstractforCoordinated alternation of DNA methylation and alternative splicing of PBRM1 affect bovine sperm structure and motility | Full Text | References | PDF (2.2 MB) | EPUB | Supplemental
  • 1444 Views
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Open Access

Brief Report

Brief Report
Validation of the new EPIC DNA methylation microarray (900K EPIC v2) for high-throughput profiling of the human DNA methylome
Aleix Noguera-Castells, Carlos A. García-Prieto, Damiana Álvarez-Errico & Manel Esteller
Article: 2185742
Published online: 05 Mar 2023
AbstractforValidation of the new EPIC DNA methylation microarray (900K EPIC v2) for high-throughput profiling of the human DNA methylome | Full Text | References | PDF (6.3 MB) | EPUB | Supplemental
  • 5893 Views
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Open Access

Research Article

Article
Pruning and thresholding approach for methylation risk scores in multi-ancestry populations
Junyu Chen, Evan Gatev, Todd Everson, Karen N. Conneely, Nastassja Koen, Michael P. Epstein, Michael S. Kobor, Heather J. Zar, Dan J. Stein & Anke Hüls
Article: 2187172
Published online: 12 Mar 2023
AbstractforPruning and thresholding approach for methylation risk scores in multi-ancestry populations | Full Text | References | PDF (2.3 MB) | EPUB | Supplemental
  • 1539 Views
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Open Access

Research Paper

Article
NAT10 mediated mRNA acetylation modification patterns associated with colon cancer progression and microsatellite status
Hailin Zhang, Wenqing Shan, Zhenwei Yang, Yangyang Zhang, Meng Wang, Liping Gao, Lingxiu Zeng, Qiu Zhao & Jing Liu
Article: 2188667
Published online: 12 Mar 2023
AbstractforNAT10 mediated mRNA acetylation modification patterns associated with colon cancer progression and microsatellite status | Full Text | References | PDF (5.7 MB) | EPUB | Supplemental
  • 2569 Views
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Open Access
Article
Histone demethylase KDM4B contributes to advanced clear cell renal carcinoma and association with copy number variations and cell cycle progression
Heting Tang, Yaping Guan, Zhihao Yuan, Tuanjie Guo, Xiangyin Tan, Yu Fan, Encheng Zhang & Xiang Wang
Article: 2192319
Published online: 23 Mar 2023
AbstractforHistone demethylase KDM4B contributes to advanced clear cell renal carcinoma and association with copy number variations and cell cycle progression | Full Text | References | PDF (3.8 MB) | EPUB | Supplemental
  • 1456 Views
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Open Access
Article
Identification and characterization of extrachromosomal circular DNA in patients with high myopia and cataract
Kai Wen, Lujie Zhang, Yang Cai, He Teng, Jingli Liang, Yi Yue, Yaoling Li, Yifang Huang, Ming Liu, Yufeng Zhang, Ruihua Wei & Jing Sun
Article: 2192324
Published online: 22 Mar 2023
AbstractforIdentification and characterization of extrachromosomal circular DNA in patients with high myopia and cataract | Full Text | References | PDF (7.5 MB) | EPUB | Supplemental
  • 2163 Views
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Open Access

Brief Report

Brief Report
In vivo DNA methylation editing in zebrafish
Fang Liang, Zijiong Dong, Jianmin Ye, Wei Hu, Ramji Kumar Bhandari, Kangsen Mai & Xuegeng Wang
Article: 2192326
Published online: 22 Mar 2023
AbstractforIn vivo DNA methylation editing in zebrafish | Full Text | References | PDF (1.4 MB) | EPUB | Supplemental
  • 2547 Views
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Open Access

Research Paper

Article
Phenotypic and transcriptomic impact of expressing mammalian TET2 in the Drosophila melanogaster model
Joy N. Ismail, Sarah Mantash, Mohammad Hallal, Nada Jabado, Pierre Khoueiry & Margret Shirinian
Article: 2192375
Published online: 29 Mar 2023
AbstractforPhenotypic and transcriptomic impact of expressing mammalian TET2 in the Drosophila melanogaster model | Full Text | References | PDF (8.4 MB) | EPUB | Supplemental
  • 1973 Views
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Open Access
Article
Suppressing circIDE/miR-19b-3p/RBMS1 axis exhibits promoting-tumour activity through upregulating GPX4 to diminish ferroptosis in hepatocellular carcinoma
Hang Zhai, Sisi Zhong, Runxin Wu, Zhaohong Mo, Shiyang Zheng, Jinhua Xue, Hongyu Meng, Maosheng Liu, Xianyu Chen, Guangquan Zhang, Xiyan Zheng, Fei Du, Ruixi Li & Boxuan Zhou
Article: 2192438
Published online: 29 Mar 2023
AbstractforSuppressing circIDE/miR-19b-3p/RBMS1 axis exhibits promoting-tumour activity through upregulating GPX4 to diminish ferroptosis in hepatocellular carcinoma | Full Text | References | PDF (8.2 MB) | EPUB | Supplemental
  • 2810 Views
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Open Access
Article
DNA hypomethylation mediates immune response in pan-cancer
Chunlong Zhang, Qi Sheng, Ning Zhao, Shan Huang & Yuming Zhao
Article: 2192894
Published online: 22 Mar 2023
AbstractforDNA hypomethylation mediates immune response in pan-cancer | Full Text | References | PDF (8.3 MB) | EPUB | Supplemental
  • 2097 Views
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Open Access
Article
Dose rate dependent reduction in chromatin accessibility at transcriptional start sites long time after exposure to gamma radiation
Hildegunn Dahl, Jarle Ballangby, Torstein Tengs, Marcin W. Wojewodzic, Dag M. Eide, Dag Anders Brede, Anne Graupner, Nur Duale & Ann-Karin Olsen
Article: 2193936
Published online: 27 Mar 2023
AbstractforDose rate dependent reduction in chromatin accessibility at transcriptional start sites long time after exposure to gamma radiation | Full Text | References | PDF (1.8 MB) | EPUB | Supplemental
  • 1350 Views
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Open Access
Article
LncRNA TUG1 promotes pulmonary fibrosis progression via up-regulating CDC27 and activating PI3K/Akt/mTOR pathway
Fei Qi, Zhong-Dong Lv, Wen-Di Huang, Shan-Chen Wei, Xin-Min Liu & Wei-Dong Song
Article: 2195305
Published online: 30 Mar 2023
AbstractforLncRNA TUG1 promotes pulmonary fibrosis progression via up-regulating CDC27 and activating PI3K/Akt/mTOR pathway | Full Text | References | PDF (5.7 MB) | EPUB | Supplemental
  • 2059 Views
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Article
DNA methylome and transcriptome profiling reveal key electrophysiology and immune dysregulation in hypertrophic cardiomyopathy
Xiaoyan Li, Hailang Fan, Xiantao Song, Bangrong Song, Wenxian Liu, Ran Dong, Haikun Zhang, Shicheng Guo, Hao Liang, Steven J. Schrodi, Xuebin Fu, Sunjay Kaushal, Yanlong Ren & Dake Zhang
Article: 2195307
Published online: 02 Apr 2023
AbstractforDNA methylome and transcriptome profiling reveal key electrophysiology and immune dysregulation in hypertrophic cardiomyopathy | Full Text | References | PDF (3.7 MB) | EPUB | Supplemental
  • 2026 Views
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Article
An enriched maternal environment and stereotypies of sows differentially affect the neuro-epigenome of brain regions related to emotionality in their piglets
Patricia Tatemoto, Fábio Pértille, Thiago Bernardino, Ricardo Zanella, Carlos Guerrero-Bosagna & Adroaldo José Zanella
Article: 2196656
Published online: 16 May 2023
AbstractforAn enriched maternal environment and stereotypies of sows differentially affect the neuro-epigenome of brain regions related to emotionality in their piglets | Full Text | References | PDF (3.7 MB) | EPUB | Supplemental
  • 1718 Views
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Article
An epigenome-wide analysis of sex hormone levels and DNA methylation in male blood samples
Justin Harbs, Sabina Rinaldi, Pekka Keski-Rahkonen, Xijia Liu, Richard Palmqvist, Bethany Van Guelpen & Sophia Harlid
Article: 2196759
Published online: 30 Mar 2023
AbstractforAn epigenome-wide analysis of sex hormone levels and DNA methylation in male blood samples | Full Text | References | PDF (702 KB) | EPUB | Supplemental
  • 1534 Views
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Open Access
Article
Identification of differentially methylated genes for severe acne by genome-wide DNA methylation and gene expression analysis
Huai Wang, Tianyuan Dang, Jiaqi Feng, Wenjuan Wu, Li He & Jiankang Yang
Article: 2199373
Published online: 05 Apr 2023
AbstractforIdentification of differentially methylated genes for severe acne by genome-wide DNA methylation and gene expression analysis | Full Text | References | PDF (2.5 MB) | EPUB | Supplemental
  • 1213 Views
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Article
Nanopore sequencing reveals methylation changes associated with obesity in circulating cell-free DNA from Göttingen Minipigs
Markus Hodal Drag, Karina Poulsdóttir Debes, Clara Sandkamm Franck, Mette Flethøj, Mille Kronborg Lyhne, Jacob Eifer Møller, Trine Pagh Ludvigsen, Thomas Jespersen, Lisbeth Høier Olsen & Tuomas O. Kilpeläinen
Article: 2199374
Published online: 10 Apr 2023
AbstractforNanopore sequencing reveals methylation changes associated with obesity in circulating cell-free DNA from Göttingen Minipigs | Full Text | References | PDF (5.9 MB) | EPUB | Supplemental
  • 2983 Views
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Article
Differential methylation pattern in pubertal girls associated with biochemical premature adrenarche
Diana Ponce, Fernando Rodríguez, José P. Miranda, Alexandra M. Binder, José L. Santos, Karin B. Michels, Gordon B. Cutler Jr, Ana Pereira, Germán Iñiguez & Verónica Mericq
Article: 2200366
Published online: 13 Apr 2023
AbstractforDifferential methylation pattern in pubertal girls associated with biochemical premature adrenarche | Full Text | References | PDF (1.7 MB) | EPUB | Supplemental
  • 1853 Views
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Article
Proposal of a bioinformatics approach to predict molecular mechanisms involved in inflammatory response: case of ATRA and 1,25(OH)2D in adipocytes
Esma Karkeni, Thomas Payet, Julien Astier, Flavie Sicard, Lourdes Mounien & Jean-François Landrier
Article: 2201516
Published online: 18 Apr 2023
AbstractforProposal of a bioinformatics approach to predict molecular mechanisms involved in inflammatory response: case of ATRA and 1,25(OH)2D in adipocytes | Full Text | References | PDF (1.8 MB) | EPUB | Supplemental
  • 1993 Views
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Brief Report

Brief Report
Age-associated DNA methylation changes in Xenopus frogs
Marco Morselli, Ronan Bennett, Nikko-Ideen Shaidani, Marko Horb, Leonid Peshkin & Matteo Pellegrini
Article: 2201517
Published online: 24 Apr 2023
AbstractforAge-associated DNA methylation changes in Xenopus frogs | Full Text | References | PDF (2.3 MB) | EPUB | Supplemental
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Research Paper

Article
Analysis of global DNA methylation and epigenetic modifiers (DNMTs and HDACs) in human foetal endothelium exposed to gestational and type 2 diabetes
Samar Sultan & Sultanh AlMalki
Article: 2201714
Published online: 17 Apr 2023
AbstractforAnalysis of global DNA methylation and epigenetic modifiers (DNMTs and HDACs) in human foetal endothelium exposed to gestational and type 2 diabetes | Full Text | References | PDF (591.7 KB) | EPUB
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Article
Comprehensive analysis of transcriptome‐wide M6A methylation for hepatic ischaemia reperfusion injury in mice
yongliang hua, xinglong Li, Bing Yin, jingjing Huang, shounan Lu, chaoqun Wang, shanjia Ke, yanan Xu, baolin Qian, zhigang Feng, hongjun Yu & yong Ma
Article: 2201716
Published online: 17 Apr 2023
AbstractforComprehensive analysis of transcriptome‐wide M6A methylation for hepatic ischaemia reperfusion injury in mice | Full Text | References | PDF (6.6 MB) | EPUB | Supplemental
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Article
A meta-analysis of epigenome-wide association studies on pregnancy vitamin B12 concentrations and offspring DNA methylation
Giulietta S. Monasso, Thanh T. Hoang, Giulia Mancano, Sílvia Fernández-Barrés, John Dou, Vincent W.V. Jaddoe, Christian M. Page, Laura Johnson, Mariona Bustamante, Kelly M. Bakulski, Siri E. Håberg, Per M. Ueland, Thomas Battram, Simon K. Merid, Erik Melén, Doretta Caramaschi, Leanne K. Küpers, Jordi Sunyer, Wenche Nystad, Sandra G. Heil, Rebecca J. Schmidt, Martine Vrijheid, Gemma C. Sharp, Stephanie J. London & Janine F. Felix
Article: 2202835
Published online: 24 Apr 2023
AbstractforA meta-analysis of epigenome-wide association studies on pregnancy vitamin B12 concentrations and offspring DNA methylation | Full Text | References | PDF (2.4 MB) | EPUB | Supplemental
  • 3713 Views
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Brief Report

Brief Report
m6A-modification regulated circ-CCT3 acts as the sponge of miR-378a-3p to promote hepatocellular carcinoma progression
Hua Liu, Yifan Jiang, Jiahua Lu, Chuanhui Peng, Zhenan Ling, Yunhao Chen, Diyu Chen, Rongliang Tong, Shusen Zheng & Jian Wu
Article: 2204772
Published online: 24 Apr 2023
Abstractform6A-modification regulated circ-CCT3 acts as the sponge of miR-378a-3p to promote hepatocellular carcinoma progression | Full Text | References | PDF (5.4 MB) | EPUB | Supplemental
  • 3582 Views
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Research Paper

Article
DNA methylation at birth and fine motor ability in childhood: an epigenome-wide association study with replication
Fadila Serdarevic, Mannan Luo, Irma Karabegović, Anne-Claire Binter, Silvia Alemany, Ryan Mutzel, Monica Guxens, Mariona Bustamante, Aida Hajdarpasic, Tonya White, Janine F Felix, Charlotte A.M. Cecil & Henning Tiemeier
Article: 2207253
Published online: 04 May 2023
AbstractforDNA methylation at birth and fine motor ability in childhood: an epigenome-wide association study with replication | Full Text | References | PDF (1.2 MB) | EPUB | Supplemental
  • 3092 Views
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Article
A novel principal component based method for identifying differentially methylated regions in Illumina Infinium MethylationEPIC BeadChip data
Yuanchao Zheng, Kathryn L. Lunetta, Chunyu Liu, Alicia K. Smith, Richard Sherva, Mark W. Miller & Mark W. Logue
Article: 2207959
Published online: 17 May 2023
AbstractforA novel principal component based method for identifying differentially methylated regions in Illumina Infinium MethylationEPIC BeadChip data | Full Text | References | PDF (4.2 MB) | EPUB | Supplemental
  • 1109 Views
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Article
GPX8 deficiency–induced oxidative stress reprogrammed m6A epitranscriptome of oral cancer cells
Xun Chen, Lingyu Yuan, Lejia Zhang, Liutao Chen, Yi He, Chao Wang, Jie Wu, Shangwu Chen, Wei Zhao & Dongsheng Yu
Article: 2208707
Published online: 11 May 2023
AbstractforGPX8 deficiency–induced oxidative stress reprogrammed m6A epitranscriptome of oral cancer cells | Full Text | References | PDF (5.5 MB) | EPUB | Supplemental
  • 1860 Views
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Research Article

Article
Circ_0003747 promotes thyroid cancer progression by sponging miR-338-3p to upregulate PLCD3 expression
Xiao-Lin Dou, Fa-Da Xia & Xin-Ying Li
Article: 2210339
Published online: 11 May 2023
AbstractforCirc_0003747 promotes thyroid cancer progression by sponging miR-338-3p to upregulate PLCD3 expression | Full Text | References | PDF (8.7 MB) | EPUB | Supplemental
  • 1594 Views
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Article
Dietary and supplemental intake of vitamins C and E is associated with altered DNA methylation in an epigenome-wide association study meta-analysis
Amena Keshawarz, Roby Joehanes, Jiantao Ma, Gha Young Lee, Ricardo Costeira, Pei-Chien Tsai, Olatz M. Masachs, Jordana T. Bell, Rory Wilson, Barbara Thorand, Juliane Winkelmann, Annette Peters, Jakob Linseisen, Melanie Waldenberger, Terho Lehtimäki, Pashupati P. Mishra, Mika Kähönen, Olli Raitakari, Mika Helminen, Carol A. Wang, Phillip E. Melton, Rae-Chi Huang, Craig E. Pennell, Therese A. O’Sullivan, Carolina Ochoa-Rosales, Trudy Voortman, Joyce B.J. van Meurs, Kristin L. Young, Misa Graff, Yujie Wang, Douglas P. Kiel, Caren E. Smith, Paul F. Jacques & Daniel Levy
Article: 2211361
Published online: 26 May 2023
AbstractforDietary and supplemental intake of vitamins C and E is associated with altered DNA methylation in an epigenome-wide association study meta-analysis | Full Text | References | PDF (869.6 KB) | EPUB | Supplemental
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Review

Review Article
Arabidopsis thaliana: a powerful model organism to explore histone modifications and their upstream regulations
Yang Yu, Sihan Wang, Ziqin Wang, Renwei Gao & Joohyun Lee
Article: 2211362
Published online: 17 May 2023
AbstractforArabidopsis thaliana: a powerful model organism to explore histone modifications and their upstream regulations | Full Text | References | PDF (2.2 MB) | EPUB | Supplemental
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Research Article

Article
Epigenome wide association study in peripheral blood of pregnant women identifies potential metabolic pathways related to gestational diabetes
Teresa María Linares-Pineda, Nerea Peña-Montero, Carolina Gutiérrez-Repiso, Fuensanta Lima-Rubio, Antonio Sánchez-Pozo, Francisco J Tinahones, María Molina-Vega, María José Picón-César & Sonsoles Morcillo
Article: 2211369
Published online: 16 May 2023
AbstractforEpigenome wide association study in peripheral blood of pregnant women identifies potential metabolic pathways related to gestational diabetes | Full Text | References | PDF (1.3 MB) | EPUB | Supplemental
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Research Paper

Article
Co-occurrence of injection drug use and hepatitis C increases epigenetic age acceleration that contributes to all-cause mortality among people living with HIV
Xiaoyu Liang, Amy C. Justice, Vincent C. Marconi, Bradley E. Aouizerat & Ke Xu
Article: 2212235
Published online: 16 May 2023
AbstractforCo-occurrence of injection drug use and hepatitis C increases epigenetic age acceleration that contributes to all-cause mortality among people living with HIV | Full Text | References | PDF (2.6 MB) | EPUB
  • 991 Views
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Article
Detecting aberrant DNA methylation in Illumina DNA methylation arrays: a toolbox and recommendations for its use
Bradley M. Downs, Sara-Jayne Thursby & Leslie Cope
Article: 2213874
Published online: 22 May 2023
AbstractforDetecting aberrant DNA methylation in Illumina DNA methylation arrays: a toolbox and recommendations for its use | Full Text | References | PDF (2.4 MB) | EPUB | Supplemental
  • 810 Views
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Article
Multiomics analysis of adaptation to repeated DNA damage in prostate cancer cells
D. Challis, T. Lippis, R. Wilson, E. Wilkinson, J. Dickinson, A. Black, I. Azimi, A. Holloway, P. Taberlay & K. Brettingham-Moore
Article: 2214047
Published online: 17 May 2023
AbstractforMultiomics analysis of adaptation to repeated DNA damage in prostate cancer cells | Full Text | References | PDF (1.9 MB) | EPUB | Supplemental
  • 1734 Views
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Article
Impact of tobacco, alcohol, and marijuana on genome-wide DNA methylation and its relationship with hypertension
Natàlia Carreras-Gallo, Varun B. Dwaraka, Alejandro Cáceres, Ryan Smith, Tavis L. Mendez, Hannah Went & Juan R Gonzalez
Article: 2214392
Published online: 22 May 2023
AbstractforImpact of tobacco, alcohol, and marijuana on genome-wide DNA methylation and its relationship with hypertension | Full Text | References | PDF (2.2 MB) | EPUB | Supplemental
  • 2832 Views
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Article
Association of DNA methylation signatures with premature ageing and cardiovascular death in patients with end-stage kidney disease: a pilot epigenome-wide association study
Keiichi Sumida, Khyobeni Mozhui, Xiaoyu Liang, Yamini Mallisetty, Zhongji Han & Csaba P. Kovesdy
Article: 2214394
Published online: 19 May 2023
AbstractforAssociation of DNA methylation signatures with premature ageing and cardiovascular death in patients with end-stage kidney disease: a pilot epigenome-wide association study | Full Text | References | PDF (1.3 MB) | EPUB | Supplemental
  • 1343 Views
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Article
DNA methylation and gene expression changes in mouse mammary tissue during successive lactations: part II – the impact of lactation rank
E Ivanova, C Hue-Beauvais, A Chaulot-Talmon, J Castille, J Laubier, C De Casanove, A Aubert-Frambourg, P Germon, H Jammes & F Le Provost
Article: 2215620
Published online: 23 May 2023
AbstractforDNA methylation and gene expression changes in mouse mammary tissue during successive lactations: part II – the impact of lactation rank | Full Text | References | PDF (1.9 MB) | EPUB | Supplemental
  • 931 Views
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Article
DNA methylation and gene expression changes in mouse mammary tissue during successive lactations: part I – the impact of inflammation
E. Ivanova, C. Hue-Beauvais, A. Chaulot-Talmon, J. Castille, J Laubier, C De Casanove, A. Aubert-Frambourg, P. Germon, H. Jammes & F. Le Provost
Article: 2215633
Published online: 11 Jun 2023
AbstractforDNA methylation and gene expression changes in mouse mammary tissue during successive lactations: part I – the impact of inflammation | Full Text | References | PDF (2.6 MB) | EPUB | Supplemental
  • 1017 Views
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Article
The UHRF1 protein is a key regulator of retrotransposable elements and innate immune response to viral RNA in human cells
RE Irwin, C Scullion, SJ Thursby, M Sun, A Thakur, L Hilman, B Callaghan, PD Thompson, DJ McKenna, SB Rothbart, Guoliang Xu & CP Walsh
Article: 2216005
Published online: 29 May 2023
AbstractforThe UHRF1 protein is a key regulator of retrotransposable elements and innate immune response to viral RNA in human cells | Full Text | References | PDF (3.2 MB) | EPUB | Supplemental
  • 1773 Views
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Article
METTL3-mediated m6A modification of lnc KCNQ1OT1 promotes doxorubicin resistance in breast cancer by regulating miR-103a-3p/MDR1 axis
Zhiyang Zhou, Yukun Cao, Yuan Yang, Shouman Wang & Feiyu Chen
Article: 2217033
Published online: 27 May 2023
AbstractforMETTL3-mediated m6A modification of lnc KCNQ1OT1 promotes doxorubicin resistance in breast cancer by regulating miR-103a-3p/MDR1 axis | Full Text | References | PDF (8.8 MB) | EPUB | Supplemental
  • 1867 Views
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Article
Occupational characteristics and epigenetic aging among older adults in the United States
Theresa Andrasfay & Eileen Crimmins
Article: 2218763
Published online: 10 Jun 2023
AbstractforOccupational characteristics and epigenetic aging among older adults in the United States | Full Text | References | PDF (889.9 KB) | EPUB | Supplemental
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Review

Review Article
RNA modification m6Am: the role in cardiac biology
Daniel Benak, Frantisek Kolar, Lu Zhang, Yvan Devaux & Marketa Hlavackova
Article: 2218771
Published online: 18 Jun 2023
AbstractforRNA modification m6Am: the role in cardiac biology | Full Text | References | PDF (2.4 MB) | EPUB
  • 1837 Views
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Research Article

Article
Sex-specific DNA methylation in saliva from the multi-ethnic Future of Families and Child Wellbeing Study
Allison Reiner, Kelly M. Bakulski, Jonah D. Fisher, John F Dou, Lisa Schneper, Colter Mitchell, Daniel A. Notterman, Matthew Zawistowski & Erin B. Ware
Article: 2222244
Published online: 10 Jun 2023
AbstractforSex-specific DNA methylation in saliva from the multi-ethnic Future of Families and Child Wellbeing Study | Full Text | References | PDF (1.5 MB) | EPUB | Supplemental
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Brief Report

Brief Report
Catalytic domain-dependent and -independent transcriptional activities of the tumour suppressor histone H3K27 demethylase UTX/KDM6A in specific cancer types
Wendi Sun, Kian Leong Lee, Lorenz Poellinger, Hisao Masai & Hiroyuki Kato
Article: 2222245
Published online: 10 Jun 2023
AbstractforCatalytic domain-dependent and -independent transcriptional activities of the tumour suppressor histone H3K27 demethylase UTX/KDM6A in specific cancer types | Full Text | References | PDF (1.9 MB) | EPUB | Supplemental
  • 1179 Views
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Research Article

Article
The role of DNA methylation on gene expression in the vertebrae of ancestrally benzo[a]pyrene exposed F1 and F3 male medaka
Teng Wan, Jiezhang Mo, Doris Wai-Ting Au, Xian Qin, Nathan Yi-Kan Tam, Richard Yuen-Chong Kong & Frauke Seemann
Article: 2222246
Published online: 15 Jun 2023
AbstractforThe role of DNA methylation on gene expression in the vertebrae of ancestrally benzo[a]pyrene exposed F1 and F3 male medaka | Full Text | References | PDF (3.5 MB) | EPUB
  • 1192 Views
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Article
Prenatal maternal stress is associated with site-specific and age acceleration changes in maternal and newborn DNA methylation
Edward B. Quinn, Chu J. Hsiao, Felicien M. Maisha & Connie J. Mulligan
Article: 2222473
Published online: 10 Jun 2023
AbstractforPrenatal maternal stress is associated with site-specific and age acceleration changes in maternal and newborn DNA methylation | Full Text | References | PDF (2.3 MB) | EPUB | Supplemental
  • 1961 Views
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Article
LncRNA NEAT1 promotes IL-6 secretion in monocyte-derived dendritic cells via sponging miR-365a-3p in systemic lupus erythematosus
Mengmeng Xiang, Yilun Wang, Qian Chen, Jie Wang, Zhanyan Gao, Jun Liang & Jinhua Xu
Article: 2226492
Published online: 21 Jun 2023
AbstractforLncRNA NEAT1 promotes IL-6 secretion in monocyte-derived dendritic cells via sponging miR-365a-3p in systemic lupus erythematosus | Full Text | References | PDF (1.4 MB) | EPUB | Supplemental
  • 1281 Views
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Article
Ribosomal DNA Copy Number Variation is Coupled with DNA Methylation Changes at the 45S rDNA Locus
Aleem Razzaq, Yosra Bejaoui, Tanvir Alam, Mohamad Saad & Nady El Hajj
Article: 2229203
Published online: 27 Jun 2023
AbstractforRibosomal DNA Copy Number Variation is Coupled with DNA Methylation Changes at the 45S rDNA Locus | Full Text | References | PDF (2 MB) | EPUB | Supplemental
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Article
m6A mRNA Methylation Analysis Provides Novel Insights into Pigmentation in Sheep Skin
Yuanyuan Zhao, Jinzhu Meng, Xingchao Song & Qingming An
Article: 2230662
Published online: 30 Jun 2023
Abstractform6A mRNA Methylation Analysis Provides Novel Insights into Pigmentation in Sheep Skin | Full Text | References | PDF (3.1 MB) | EPUB | Supplemental
  • 1031 Views
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Article
Epimutation detection in the clinical context: guidelines and a use case from a new Bioconductor package
Carlos Ruiz-Arenas, Leire Abarrategui, Carles Hernandez-Ferrer, Xavier Escribà-Montagut, Dolors Pelegrí-Sisó, Patricia Ryser-Welch, Martine Vrijheid, Mariona Bustamante, Regina Grazuleviciene, Johanna Lepeule, Mathew Mathai, Marina Vafeiadi, Sergi Beltran, Luis A Pérez-Jurado & Juan R González
Article: 2230670
Published online: 06 Jul 2023
AbstractforEpimutation detection in the clinical context: guidelines and a use case from a new Bioconductor package | Full Text | References | PDF (1.4 MB) | EPUB | Supplemental
  • 1072 Views
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Article
Biological stability of DNA methylation measurements over varying intervals of time and in the presence of acute stress
Abner T. Apsley, Qiaofeng Ye, Laura Etzel, Sarah Wolf, Waylon J. Hastings, Brooke C. Mattern, Sue Rutherford Siegel & Idan Shalev
Article: 2230686
Published online: 02 Jul 2023
AbstractforBiological stability of DNA methylation measurements over varying intervals of time and in the presence of acute stress | Full Text | References | PDF (4.8 MB) | EPUB | Supplemental
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Article
Pan-precancer and cancer DNA methylation profiles revealed significant tissue specificity of interrupted biological processes in tumorigenesis
Feifan Zhang, Xin Zhang, Haikun Zhang, Dongdong Lin, Hailang Fan, Shicheng Guo, Fang An, Yaqian Zhao, Jun Li, Steven J. Schrodi & Dake Zhang
Article: 2231222
Published online: 02 Jul 2023
AbstractforPan-precancer and cancer DNA methylation profiles revealed significant tissue specificity of interrupted biological processes in tumorigenesis | Full Text | References | PDF (3.4 MB) | EPUB | Supplemental
  • 1238 Views
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Article
Identification cloning and functional analysis of novel natural antisense lncRNA CFL1-AS1 in cattle
Yaoyao Ma, Tianqi Zhao, Xinyi Wu, Zhangping Yang & Yujia Sun
Article: 2231707
Published online: 05 Jul 2023
AbstractforIdentification cloning and functional analysis of novel natural antisense lncRNA CFL1-AS1 in cattle | Full Text | References | PDF (5.7 MB) | EPUB | Supplemental
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Article
Cumulative stress, PTSD, and emotion dysregulation during pregnancy and epigenetic age acceleration in Hispanic mothers and their newborn infants
Seyma Katrinli, Alicia K Smith, Stacy S. Drury, Jonathan Covault, Julian D. Ford, Vijender Singh, Bo Reese, Amy Johnson, Victoria Scranton, Pamela Fall, Margaret Briggs-Gowan & Damion J Grasso
Article: 2231722
Published online: 11 Jul 2023
AbstractforCumulative stress, PTSD, and emotion dysregulation during pregnancy and epigenetic age acceleration in Hispanic mothers and their newborn infants | Full Text | References | PDF (908.4 KB) | EPUB | Supplemental
  • 1718 Views
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Article
Intergenerational effects of early life-stage temperature modulation on gene expression and DNA methylation in Atlantic cod (Gadus morhua)
Velmurugu Puvanendran, Erik Burgerhout, Øivind Andersen, Matthew Kent, Øyvind Hansen & Torstein Tengs
Article: 2237759
Published online: 27 Jul 2023
AbstractforIntergenerational effects of early life-stage temperature modulation on gene expression and DNA methylation in Atlantic cod (Gadus morhua) | Full Text | References | PDF (2 MB) | EPUB | Supplemental
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Review

Review Article
Brain Tumors: Development, Drug Resistance, and Sensitization – An Epigenetic Approach
Sibaji Sarkar, Tara Deyoung, Hope Ressler & Whitney Chandler
Article: 2237761
Published online: 27 Jul 2023
AbstractforBrain Tumors: Development, Drug Resistance, and Sensitization – An Epigenetic Approach | Full Text | References | PDF (2.4 MB) | EPUB
  • 1355 Views
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Research Article

Article
MYOD induced lnc-MEG3 promotes porcine satellite cell differentiation via interacting with DLST
Quan Liu, Mengxun Li, Su Xie, Cheng Tian, Jiaxuan Li, Yuan Wang, Xin Li & Changchun Li
Article: 2237789
Published online: 28 Jul 2023
AbstractforMYOD induced lnc-MEG3 promotes porcine satellite cell differentiation via interacting with DLST | Full Text | References | PDF (7.1 MB) | EPUB | Supplemental
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Article
ZNF143 inhibits hepatocyte mitophagy and promotes non-alcoholic fatty liver disease by targeting increased lncRNA NEAT1 expression to activate ROCK2 pathway
Yujie Dong, Minjie Hu, Kewei Tan & Rongjuan Dai
Article: 2239592
Published online: 11 Aug 2023
AbstractforZNF143 inhibits hepatocyte mitophagy and promotes non-alcoholic fatty liver disease by targeting increased lncRNA NEAT1 expression to activate ROCK2 pathway | Full Text | References | PDF (19.2 MB) | EPUB | Supplemental
  • 1632 Views
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Article
Oncogenic DNA methyltransferase 1 activates the PI3K/AKT/mTOR signalling by blocking the binding of HSPB8 and BAG3 in melanoma
Yemei Yang, Shengfang Ma, Zi Ye, Yushi Zheng, Zhenjiong Zheng, Xiongshan Liu & Xianyi Zhou
Article: 2239607
Published online: 31 Jul 2023
AbstractforOncogenic DNA methyltransferase 1 activates the PI3K/AKT/mTOR signalling by blocking the binding of HSPB8 and BAG3 in melanoma | Full Text | References | PDF (8.5 MB) | EPUB | Supplemental
  • 889 Views
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Article
Epigenetic aging in cows is accelerated by milk production
Prashansa Ratan, Liudmilla Rubbi, Michael Thompson, Kaushik Naresh, Jolena Waddell, Barbara Jones & Matteo Pellegrini
Article: 2240188
Published online: 02 Aug 2023
AbstractforEpigenetic aging in cows is accelerated by milk production | Full Text | References | PDF (2.8 MB) | EPUB | Supplemental
  • 1287 Views
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Article
Histone deacetylase 3 regulates microglial function through histone deacetylation
Laura Meleady, Morgan Towriss, Jennifer Kim, Vince Bacarac, Vivien Dang, Megan E. Rowland & Annie Vogel Ciernia
Article: 2241008
Published online: 28 Jul 2023
AbstractforHistone deacetylase 3 regulates microglial function through histone deacetylation | Full Text | References | PDF (8.5 MB) | EPUB | Supplemental
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Article
Impact of testicular cancer on sperm small non-coding RNA signature: a pilot study
Charlotte Dupont, Maria G. Stathopoulou, Pierre-Julien Illy, Nathalie Sermondade, Rachel Levy, Michele Trabucchi, Marie Prades, Rahaf Haj Hamid, Isabelle Berthaut & Valérie Grandjean
Article: 2241009
Published online: 29 Jul 2023
AbstractforImpact of testicular cancer on sperm small non-coding RNA signature: a pilot study | Full Text | References | PDF (1.6 MB) | EPUB | Supplemental
  • 751 Views
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Article
Genome-wide methylation profile of mitochondrial DNA across bovine preimplantation development
Camila Bruna de Lima, Hélène Martin, Marcella Pecora Milazzotto & Marc-André Sirard
Article: 2241010
Published online: 31 Jul 2023
AbstractforGenome-wide methylation profile of mitochondrial DNA across bovine preimplantation development | Full Text | References | PDF (1.2 MB) | EPUB | Supplemental
  • 1074 Views
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Article
Comprehensive analysis of m6A methylomes in idiopathic pulmonary arterial hypertension
Ting Huang, Yunhong Zeng, Yao Yang, Haoqin Fan, Youcai Deng, Wenjuan Chen, Jinqiao Liu, Fan Yang, Wenfeng Li & Yunbin Xiao
Article: 2242225
Published online: 04 Aug 2023
AbstractforComprehensive analysis of m6A methylomes in idiopathic pulmonary arterial hypertension | Full Text | References | PDF (3.7 MB) | EPUB
  • 1471 Views
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Article
FTO promotes proliferation and migration of bladder cancer via enhancing stability of STAT3 mRNA in an m6A-dependent manner
Zhuang Sun, Xiaolu Sun, Guoliang Qin, Yi Li, Guanwen Zhou & Xianzhou Jiang
Article: 2242688
Published online: 04 Aug 2023
AbstractforFTO promotes proliferation and migration of bladder cancer via enhancing stability of STAT3 mRNA in an m6A-dependent manner | Full Text | References | PDF (3.2 MB) | EPUB | Supplemental
  • 1115 Views
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Open Access

Review Article

Review Article
To target or not to target? The role of DNA and histone methylation in bacterial infections
Magdalena Barbachowska & Paola B. Arimondo
Article: 2242689
Published online: 20 Sep 2023
AbstractforTo target or not to target? The role of DNA and histone methylation in bacterial infections | Full Text | References | PDF (1.9 MB) | EPUB
  • 1104 Views
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Research Article

Article
DNA methylation biomarkers to identify epigenetically abnormal spermatozoa in male partners from couples experiencing recurrent pregnancy loss
Kushaan Khambata, Shahina Begum, Sanketa Raut, Sweta Mohan, Delna Irani, Dipty Singh, Vandana Bansal, Anushree Patil & Nafisa H. Balasinor
Article: 2252244
Published online: 12 Sep 2023
AbstractforDNA methylation biomarkers to identify epigenetically abnormal spermatozoa in male partners from couples experiencing recurrent pregnancy loss | Full Text | References | PDF (477.1 KB) | EPUB | Supplemental
  • 824 Views
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Research article

Article
Pleiotropic influence of DNA methylation QTLs on physiological and ageing traits
Khyobeni Mozhui, Hyeonju Kim, Flavia Villani, Amin Haghani, Saunak Sen & Steve Horvath
Article: 2252631
Published online: 10 Sep 2023
AbstractforPleiotropic influence of DNA methylation QTLs on physiological and ageing traits | Full Text | References | PDF (4.2 MB) | EPUB | Supplemental
  • 1436 Views
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Open Access

Brief report

Brief Report
Accelerated epigenetic age at birth and child emotional and behavioural development in early childhood: a meta-analysis of four prospective cohort studies in ECHO
Ashley Y. Song, Catherine M. Bulka, Sierra S. Niemiec, Katerina Kechris, Kristen E. Boyle, Carmen J. Marsit, T. Michael O’Shea, Rebecca C. Fry, Kristen Lyall, M. Daniele Fallin, Heather E. Volk & Christine Ladd-Acosta
Article: 2254971
Published online: 10 Sep 2023
AbstractforAccelerated epigenetic age at birth and child emotional and behavioural development in early childhood: a meta-analysis of four prospective cohort studies in ECHO | Full Text | References | PDF (772.7 KB) | EPUB | Supplemental
  • 1248 Views
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Research article

Article
DNMT1 expression partially dictates 5-Azacytidine sensitivity and correlates with RAS/MEK/ERK activity in gastric cancer cells
Zhangqian Chen, Lin Zhang, Yang Yang, Haiming Liu, Xiaoyu Kang, Yongzhan Nie & Daiming Fan
Article: 2254976
Published online: 10 Sep 2023
AbstractforDNMT1 expression partially dictates 5-Azacytidine sensitivity and correlates with RAS/MEK/ERK activity in gastric cancer cells | Full Text | References | PDF (4.2 MB) | EPUB | Supplemental
  • 1089 Views
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Open Access

Brief report

Brief Report
A consistent pattern of slide effects in Illumina DNA methylation BeadChip array data
Julian Hecker, Sanghun Lee, Priyadarshini Kachroo, Dmitry Prokopenko, Anna Maaser-Hecker, Sharon M. Lutz, Georg Hahn, Rafael Irizarry, Scott T. Weiss, Dawn L. DeMeo & Christoph Lange
Article: 2257437
Published online: 20 Sep 2023
AbstractforA consistent pattern of slide effects in Illumina DNA methylation BeadChip array data | Full Text | References | PDF (1.3 MB) | EPUB | Supplemental
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Research article

Article
ATG9A modulated by miR-195-5p can boost the malignant progression of cervical cancer cells
Xiaomin Liu, Zhen Liu, Yonggang Liu & Ning Wang
Article: 2257538
Published online: 02 Oct 2023
AbstractforATG9A modulated by miR-195-5p can boost the malignant progression of cervical cancer cells | Full Text | References | PDF (5.2 MB) | EPUB
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Review

Review Article
N6-methyladenosine (m6A) modification in osteosarcoma: expression, function and interaction with noncoding RNAs – an updated review
Yuanzhuang Zhang, Yeqiu Xu, Yuxin Bao, Yinzhou Luo, Guanzhen Qiu, Ming He, Jie Lu, Jian Xu, Bin Chen & Yong Wang
Article: 2260213
Published online: 28 Sep 2023
AbstractforN6-methyladenosine (m6A) modification in osteosarcoma: expression, function and interaction with noncoding RNAs – an updated review | Full Text | References | PDF (2 MB) | EPUB
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Review Article
The influence of intergenerational trauma on epigenetics and obesity in Indigenous populations - a scoping review
Krista Schafte & Sean Bruna
Article: 2260218
Published online: 26 Sep 2023
AbstractforThe influence of intergenerational trauma on epigenetics and obesity in Indigenous populations - a scoping review | Full Text | References | PDF (369.8 KB) | EPUB
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Research article

Article
Sex-specific DNA methylation and transcription of zbtb38 and effects of gene–environment interactions on its natural antisense transcript in zebrafish
Fabien Pierron, Flore Daramy, Débora Heroin, Guillemine Daffe, Aurélien Barré, Olivier Bouchez & Macha Nikolski
Article: 2260963
Published online: 02 Oct 2023
AbstractforSex-specific DNA methylation and transcription of zbtb38 and effects of gene–environment interactions on its natural antisense transcript in zebrafish | Full Text | References | PDF (2.4 MB) | EPUB | Supplemental
  • 717 Views
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Article
IL-18 serves as a main effector of CAF-derived METTL3 against immunosuppression of NSCLC via driving NF-κB pathway
Li Xu, Kang Li, Jia Li, Fang Xu, Shuzhi Liang, Yi Kong & Bolin Chen
Article: 2265625
Published online: 23 Oct 2023
AbstractforIL-18 serves as a main effector of CAF-derived METTL3 against immunosuppression of NSCLC via driving NF-κB pathway | Full Text | References | PDF (6 MB) | EPUB | Supplemental
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Review

Review Article
Domain architecture and protein–protein interactions regulate KDM5A recruitment to the chromatin
Avishek Kataria & Shweta Tyagi
Article: 2268813
Published online: 15 Oct 2023
AbstractforDomain architecture and protein–protein interactions regulate KDM5A recruitment to the chromatin | Full Text | References | PDF (1.8 MB) | EPUB
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Brief report

Brief Report
Utility of ASNS gene methylation evaluated with the HPLC method as a pharmacogenomic biomarker to predict asparaginase sensitivity in BCP-ALL
Atsushi Watanabe, Kunio Miyake, Yuriko Yamada, Ei-Ichiro Sunamura, Takuya Yotani, Keiko Kagami, Shin Kasai, Minori Tamai, Daisuke Harama, Koshi Akahane, Kumiko Goi, Kimiyoshi Sakaguchi, Hiroaki Goto, Shinichiro Kitahara & Takeshi Inukai
Article: 2268814
Published online: 15 Oct 2023
AbstractforUtility of ASNS gene methylation evaluated with the HPLC method as a pharmacogenomic biomarker to predict asparaginase sensitivity in BCP-ALL | Full Text | References | PDF (2 MB) | EPUB | Supplemental
  • 626 Views
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Research article

Article
Epigenome-wide association study of systemic effects of obesity susceptibility in human twins
Glen E. Duncan, Ally Avery, Millissia Ben Maamar, Eric E. Nilsson, Daniel Beck & Michael K. Skinner
Article: 2268834
Published online: 23 Oct 2023
AbstractforEpigenome-wide association study of systemic effects of obesity susceptibility in human twins | Full Text | References | PDF (3.9 MB) | EPUB | Supplemental
  • 2177 Views
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Article
A newly identified lncRNA lnc000100 regulates proliferation and differentiation of cattle skeletal muscle cells
Mengke Ma, Mengjie Chen, Xiaoyun Wu, Suren R. Sooranna, Qingyou Liu, Deshun Shi, Jian Wang & Hui Li
Article: 2270864
Published online: 01 Nov 2023
AbstractforA newly identified lncRNA lnc000100 regulates proliferation and differentiation of cattle skeletal muscle cells | Full Text | References | PDF (4.9 MB) | EPUB | Supplemental
  • 1057 Views
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Article
Analysis of genome-wide 5-hydroxymethylation of blood samples stored in different anticoagulants: opportunities for the expansion of clinical resources for epigenetic research
Lu Gao, Zhou Zhang, Xiao-Long Cui, Diana West-Szymanski, Chang Ye, Chuan He, Wei Zhang & Marc Bissonnette
Article: 2271692
Published online: 29 Oct 2023
AbstractforAnalysis of genome-wide 5-hydroxymethylation of blood samples stored in different anticoagulants: opportunities for the expansion of clinical resources for epigenetic research | Full Text | References | PDF (3.8 MB) | EPUB | Supplemental
  • 958 Views
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Article
Alternative splicing of IRF3 plays an important role in the development of hepatocarcinoma
Zhenyi Lv, Wenqi Gao, Zhiwei Du, Yi Zheng, Tianming Liu, Chenjun Hao & Dongbo Xue
Article: 2276371
Published online: 05 Nov 2023
AbstractforAlternative splicing of IRF3 plays an important role in the development of hepatocarcinoma | Full Text | References | PDF (10.3 MB) | EPUB
  • 703 Views
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Article
ELOVL2-AS1 suppresses tamoxifen resistance by sponging miR-1233-3p in breast cancer
Hyeon Woo Kim, Minjae Baek, Sanghyun Jung, Siyeon Jang, Hyeonjin Lee, Seung-Hoon Yang, Beom Seok Kwak & Sun Jung Kim
Article: 2276384
Published online: 31 Oct 2023
AbstractforELOVL2-AS1 suppresses tamoxifen resistance by sponging miR-1233-3p in breast cancer | Full Text | References | PDF (5.8 MB) | EPUB | Supplemental
  • 798 Views
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Article
Analysis of the interplay between MeCP2 and histone H1 during in vitro differentiation of human ReNCell neural progenitor cells
Edilene Siqueira, Bo-Hyun Kim, Larry Reser, Robert Chow, Kerry Delaney, Manel Esteller, Mark M. Ross, Jeffrey Shabanowitz, Donald F. Hunt, Sonia Guil & Juan Ausió
Article: 2276425
Published online: 17 Nov 2023
AbstractforAnalysis of the interplay between MeCP2 and histone H1 during in vitro differentiation of human ReNCell neural progenitor cells | Full Text | References | PDF (7.1 MB) | EPUB | Supplemental
  • 1421 Views
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Article
Regulatory networks of circRNA- centred ceRNAs in sepsis-induced acute kidney injury
Tongtong Ma, Junjie Wu & Zhongqing Chen
Article: 2278960
Published online: 18 Nov 2023
AbstractforRegulatory networks of circRNA- centred ceRNAs in sepsis-induced acute kidney injury | Full Text | References | PDF (5.9 MB) | EPUB | Supplemental
  • 874 Views
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Article
Epigenetic age acceleration, neonatal morbidities, and neurobehavioral profiles in infants born very preterm
Uriel Paniagua, Barry M. Lester, Carmen J. Marsit, Marie Camerota, Brian S. Carter, Jennifer F. Check, Jennifer Helderman, Julie A. Hofheimer, Elisabeth C. McGowan, Charles R. Neal, Steven L. Pastyrnak, Lynne M. Smith, Sheri A. DellaGrotta, Lynne M. Dansereau, T. Michael O’Shea & Todd M. Everson
Article: 2280738
Published online: 20 Nov 2023
AbstractforEpigenetic age acceleration, neonatal morbidities, and neurobehavioral profiles in infants born very preterm | Full Text | References | PDF (1.6 MB) | EPUB
  • 729 Views
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Article
DNA methylation profiles in bovine sperm are associated with daughter fertility
Ying Zhang, Clément Plessis, Julien Prunier, Hélène Martin, Rémi Labrecque & Marc André Sirard
Article: 2280889
Published online: 20 Nov 2023
AbstractforDNA methylation profiles in bovine sperm are associated with daughter fertility | Full Text | References | PDF (2.5 MB) | EPUB | Supplemental
  • 782 Views
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Brief report

Brief Report
Gaps in current methods to detect polymorphic CpGs from Illumina Infinium human methylation microarrays and exploring their potential impact in multi-EWAS analyses
Basharat Bhat & Gregory T Jones
Article: 2281153
Published online: 20 Nov 2023
AbstractforGaps in current methods to detect polymorphic CpGs from Illumina Infinium human methylation microarrays and exploring their potential impact in multi-EWAS analyses | Full Text | References | PDF (2.5 MB) | EPUB | Supplemental
  • 474 Views
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Research article

Article
Examination of newborn DNA methylation among women with polycystic ovary syndrome/hirsutism
Kristen J. Polinski, Sonia L. Robinson, Diane L. Putnick, Rajeshwari Sundaram, Erin Bell, Paule V. Joseph, James Segars, Weihua Guan, Robert M. Silver, Enrique F. Schisterman, Sunni L. Mumford & Edwina H. Yeung
Article: 2282319
Published online: 22 Nov 2023
AbstractforExamination of newborn DNA methylation among women with polycystic ovary syndrome/hirsutism | Full Text | References | PDF (403.8 KB) | EPUB | Supplemental
  • 799 Views
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Article
DNA hydroxymethylation differences underlie phenotypic divergence of somatic growth in Nile tilapia reared in common garden
Ioannis Konstantinidis, Pål Sætrom, Marine S. O. Brieuc, Kjetill S. Jakobsen, Hannes Liedtke, Caroline Pohlmann, Thomais Tsoulia & Jorge M. O. Fernandes
Article: 2282323
Published online: 27 Nov 2023
AbstractforDNA hydroxymethylation differences underlie phenotypic divergence of somatic growth in Nile tilapia reared in common garden | Full Text | References | PDF (5.6 MB) | EPUB | Supplemental
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