Isoarenarol, A New Protein Kinase Inhibitor from the Marine Sponge Dysidea arenaria

Hye-Dong Yoo Departments of Chemistry and Oceanography-Earth and Ocean Sciences, University of British Columbia, Vancouver, Canada;

Dan Leung Pharmaceuticals Inc., Vancouver, British Columbia;

Jasbinder Sanghara Pharmaceuticals Inc., Vancouver, British Columbia;

Darren Daley Pharmaceuticals Inc., Vancouver, British Columbia;

Rob Soest Department of Coelenterates and Porifera, Institute for Systematics and Population Biology, (Zoologisch Museum) University of Amsterdam, Amsterdam, The Netherlands

Raymond J. Andersen Departments of Chemistry and Oceanography-Earth and Ocean Sciences, University of British Columbia, Vancouver, Canada;

Abstract

The novel sesquiterpene hydroquinone isoarenarol (1) and the known compound arenarol (2) were isolated from extracts of the marine sponge Dysidea arenaria Bergquist as part of a search for new protein kinase inhibitors. Both 1 and 2 showed potent and selective protein kinase inhibition in vitro.

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Isoarenarol, A New Protein Kinase Inhibitor from the Marine Sponge Dysidea arenaria

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Isoarenarol, A New Protein Kinase Inhibitor from the Marine Sponge Dysidea arenaria

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