Toxicological Study of the Hydroalcoholic Extract from Amburana cearensis in Rats

Abstract

This work studied the effects of the hydroalcoholic extract (HAE) from Amburana cearensis on the biochemical and haematological parameters as well as on reproduction in rats. HAE (500 mg/kg, p.o.) was administered daily for 30 or 50 days (reproduction studies) to male and female Wistar rats (10 animals per group). Except for 49% increases in ALT level in the male-treated group, no other significant effect was detected on the biochemical parameters studied (glucose, ALP, AST, ALT, urea, triglycerides, lipids and cholesterol). Similarly, except for an 68% increase in neutrophil number in the male-treated group, no other significant effects were observed on the haematological parameters as compared to controls. On the other hand, creatinine concentration was decreased around 29% in the female group. The results of the reproduction study showed that there were no toxic effects on pups (1 st generation) after the subchronic HAE administration.