Research progress of hyperthermia in tumor therapy by influencing metabolic reprogramming of tumor cells

Abstract

Cellular metabolic reprogramming is an important feature of malignant tumors. Metabolic reprogramming causes changes in the levels or types of specific metabolites inside and outside the cell, which affects tumorigenesis and progression by influencing gene expression, the cellular state, and the tumor microenvironment. During tumorigenesis, a series of changes in the glucose metabolism, fatty acid metabolism, amino acid metabolism, and cholesterol metabolism of tumor cells occur, which are involved in the process of cellular carcinogenesis and constitute part of the underlying mechanisms of tumor formation. Hyperthermia, as one of the main therapeutic tools for malignant tumors, has obvious effects on tumor cell metabolism. In this paper, we will combine the latest research progress in the field of cellular metabolic reprogramming and focus on the current experimental research and clinical treatment of hyperthermia in cellular metabolic reprogramming to discuss the feasibility of cellular metabolic reprogramming-related mechanisms guiding hyperthermia in malignant tumor treatment, so as to provide more ideas for hyperthermia to treat malignant tumors through the direction of cellular metabolic reprogramming.

Keywords:

• Tumor metabolism
• metabolic reprogramming
• hyperthermia
• combination therapy

Disclosure statement

No potential conflict of interest was reported by the author(s).

Data availability statements

Data availability is not applicable to this article as no new data were created or analyzed in this study.

Additional information

Funding

This work was supported by a Grant (LHGJ20220371) from Health Commission of Henan Province.