Application of the ESHO-QA guidelines for determining the performance of the LCA superficial hyperthermia heating system

Abstract

Purpose

This study aimed to assess the quality of the lucite cone applicator (LCA), the standard applicator for superficial hyperthermia at the Erasmus MC Cancer Institute, using the most recent quality assurance guidelines, thus verifying their feasibility.

Materials and methods

The assessment was conducted on each of the six LCAs available for clinical treatments. The temperature distribution was evaluated using an infrared camera across different layers of a fat-muscle mimicking phantom. The maximum temperature increase, thermal effective penetration depth (TEPD), and thermal effective field size (TEFS) were used as quality metrics. The experimental results were validated through comparison with simulated results, using a canonical phantom model and a realistic phantom model segmented from CT imaging.

Results

A maximum temperature increase above 6 °C at 2 cm depth in the fat-muscle phantom for all the experiments was found. A mean negative difference between simulated and experimental data was of 1.3 °C when using the canonical phantom model. This value decreased to a mean negative difference of 0.4 °C when using the realistic model. Simulated and measured TEPD showed good agreement for both in silico scenarios, while discrepancies were present for TEFS.

Conclusions

The LCAs passed all QA guidelines requirements for superficial hyperthermia delivery when used singularly or in an array configuration. A further characterization of parameters such as antenna efficiency and heat transfer coefficients would be beneficial for translating experimental results to simulated values. Implementing the QA guidelines was time-consuming and demanding, requiring careful preparation and correct setup of antenna elements.

Keywords:

• Hyperthermia
• quality assurance (QA)
• superficial applicators
• LCA

Disclosure statement

No potential conflict of interest was reported by the aauthors.

Data availability statement

Raw data were generated at Erasmus MC, Rotterdam. Derived data supporting the findings of this study are available from the corresponding author C.C.S. on request.

Additional information

Funding

This research has received support from the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie (MSCA-ITN) grant ‘Hyperboost’ project, no. 955625.