Microwave ablation for recurrent primary hyperparathyroidism in four patients with multiple endocrine neoplasia type 1: a case series report

Abstract

Multiple endocrine neoplasia type 1 (MEN1), a rare tumor syndrome, is inherited in an autosomal dominant pattern, mainly manifested as primary hyperparathyroidism (PHPT). Surgery is preferred for patients with MEN1 and PHPT. Thermal ablation has been widely applied for PHPT but rarely for postoperative recurrent PHPT in MEN1 patients. Based on a series of cases, we aimed to investigate the clinical efficacy and safety of ultrasound-guided percutaneous microwave ablation in the treatment of MEN1 patients with postoperative recurrence of PHPT.

Keywords:

• Microwave ablation
• recurrence
• primary hyperparathyroidism
• multiple endocrine neoplasia
• case series report

Acknowledgements

We appreciate Qing Guo, Yalin Wang, and Yang Xu for their assistance with the ablation and data collection.

Ethical approval

The study was conducted in accordance with the Declaration of Helsinki, and approved by the Ethics Committee of Jiangsu Province Hospital of Integrated Traditional and Western Medicine (protocol code 2023-LWKYZ-070).

Informed consent

Written informed consent for publication of patients’ details was obtained from them or their parent.

Authors contributions

Jie Tan, Yuzhi Zhang, and Shuhang Xu were responsible for data collection and analysis. Guofang Chen, Chao Liu, and Shuhang Xu participated in this study. Shuhang Xu performed the microwave ablation. Xue Han, Yaofu Fan, and Juan Xu were responsible for the perioperative management. Jie Tan drafted the manuscript. Shuhang Xu critically revised the manuscript for intellectual content. All authors agreed to take responsibility for the integrity of the data and the accuracy of data analysis, and approved the final version of the manuscript.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Data availability statement

All data are made available by the authors on request without undue reservation.

Additional information

Funding

This study was funded by the Jiangsu Provincial Key Research and Development Program [BE2020726] and Medical Scientific Research Foundation of Jiangsu Province of China [M2020102].