Mary has a little chair: Eliciting noun-modifier phrases in individuals with acute post-stroke aphasia

ABSTRACT

Background

Aphasia assessment primarily examines an individual’s syntax, nouns, and verbs. However, modifiers, such as adjectives and number words, and bound morphemes can be the subject of considerable difficulty for individuals with aphasia. The Morphosyntactic Generation (MorGen) targets nouns, modifiers, and bound inflectional morphemes in two-word phrases among people with aphasia.

Aims

The purpose of this work is to provide the first report of the MorGen in hyperacute-acute aphasia. In doing so, we aim to (1) examine the MorGen’s concurrent validity with common assessments of aphasia; (2) describe performance in modifiers by people with acute aphasia; and (3) associate MorGen performance with extent of lesioned vascular territories in acute stroke.

Methods & Procedures

62 adult English speakers within the first 14 days of left hemisphere ischemic stroke and 61 healthy control participants completed the MorGen. In addition to receiving the MorGen, participants with stroke received the Western Aphasia Battery (WAB), Boston Naming Test, and Hopkins Action Naming Assessment. Clinical MRIs were analyzed for the extent of lesion in the vascular territory of the left anterior, medial, and posterior cerebral artery, as well as the left posterior choroidal and thalamoperforator arteries.

Outcomes & Results

Aim 1: Performance on the MorGen demonstrated consistently high, significant correlations with that on the WAB, Boston Naming Test, and Hopkins Action Naming Assessment. Aim 2: Individuals who had a stroke but were within functional limits (WFL) on the WAB performed significantly worse than healthy controls on the MorGen, driven by differences in adjective performance. When controlling for aphasia severity, those with fluent aphasia performed significantly better in their production of nouns, plurals, number, size, and color than those who had non-fluent aphasia, but both groups were similarly inclined to omit genitive marking. Aim 3: Lesions in the territory of the temporal branch of the posterior cerebral artery were associated with poorer performance in nouns, size, and color. Lesions in the territory of the anterior cerebral artery were associated with poorer performance in numbers.

Conclusions

This work highlights the value of the MorGen as a tool for post-stroke language evaluation that complements the skills captured in more widely-used assessments such as the WAB and BNT.

KEYWORDS:

• aphasia
• stroke
• production
• plural
• modifiers

Disclosure statement

Dr. Hillis receives compensation from the American Heart Association as Editor-in-Chief of Stroke and from Elsevier as Associate Editor of PracticeUpdate Neurology. All authors receive salary support from NIH (NIDCD) through grants.

Data availability statement

Deidentified participant data will be made available upon publication from the Johns Hopkins University Research Data Repository. Study protocol and related documents are available via ClinicalTrials.gov.

Additional information

Funding

This work is supported by National Institutes of Health/National Institute on Deafness and Other Communication Disorders (NIH/NIDCD): R01 DC005375 and P50 DC014664. The MRI equipment in this study was funded by NIH grant 1S10OD021648.