Protective effect of Eisenia foetida coelomic fluid against oxidative damage in human endothelial cells

Abstract

The protective effect of Eisenia foetida coelomic fluid on hydrogen peroxide-induced oxidative damage and cell death was determined at gene and protein levels. The coelomic fluid protects viability and cell morphology in human umbilical vein endothelial cells, and decreases reactive oxygen species production and apoptotic cells and increases anti-oxidative gene and protein expressions. Eisenia foetida coelomic fluid is potentially a therapeutic candidate for drug development.

Keywords:

• Eisenia foetida; coelomic fluid; protective effect; oxidative stress; ephitelial cell; toxicity

Acknowledgments

We thank to the Assoc. Prof. Dr. Ozlem Aksoy from the Department of Biology, Kocaeli University for supporting our experiments.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This work was supported by the Kocaeli University-Scientific Research Projects Unit (KOU-BAP) under Grant [number FYL-2021-2658].