A review of pulmonary toxicity studies of nanocellulose

Abstract

In recent years, nanocellulose (NC) obtained by defibrating cellulose to the nanometer level has been developed, and its development for various applications, e.g. as an additive for cosmetics and as a component of structural elements, is progressing. However, because NC has unique physico-chemical properties that are not found in conventional nanomaterials, particularly when inhaled, there are concerns about unexpected effects on organisms. This review summarizes the progress of in vivo experiments on the effects of NC on the respiratory system by inhalation. In addition, this review will provide new insights into NC toxicity studies by comparing the effects of fibrous nanomaterials.

Keywords:

• Nanocellulose
• exposure
• inhalation toxicity
• intratracheal administration
• oxidative stress

Disclosure statement

The authors declare no conflicts of interest.

Additional information

Funding

This work was supported by the grant of the New Energy and Industrial Technology Development Organization (NEDO) [grant number P13006].