ANTICOMPLEMENTARY ACTIVITY AND COMPLETE¹³C NMR ASSIGNMENT OF CITROSTADIENOL FROMSCHIZANDRA CHINENSIS

Im Sean Lee Korea Research Institute of Bioscience & Biotechnology, KIST, P.O. Box 115, Yusong Taejon, 305-600, Korea

Sei Ryang Oh Korea Research Institute of Bioscience & Biotechnology, KIST, P.O. Box 115, Yusong Taejon, 305-600, Korea

Keun Young Jung Korea Research Institute of Bioscience & Biotechnology, KIST, P.O. Box 115, Yusong Taejon, 305-600, Korea

Dong Sean Kim Korea Research Institute of Bioscience & Biotechnology, KIST, P.O. Box 115, Yusong Taejon, 305-600, Korea

Jung Hee Kim Korea Research Institute of Bioscience & Biotechnology, KIST, P.O. Box 115, Yusong Taejon, 305-600, Korea

Hyeong-Kyu Lee Korea Research Institute of Bioscience & Biotechnology, KIST, P.O. Box 115, Yusong Taejon, 305-600, Korea

Abstract

Citrostadienol was isolated from the fruits of Schizandra chinensis Baill: (Schizandraceae) by silica gel chromatography and assigned fully by spectroscopic analyses (¹H-¹H COSY: HMQC and HMBC). It demonstrated higher inhibition activity on classical complement pathway (IC₅₀, 4.6 × 10⁻⁸M) than previously reported active steroids.

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ANTICOMPLEMENTARY ACTIVITY AND COMPLETE¹³C NMR ASSIGNMENT OF CITROSTADIENOL FROMSCHIZANDRA CHINENSIS

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ANTICOMPLEMENTARY ACTIVITY AND COMPLETE13C NMR ASSIGNMENT OF CITROSTADIENOL FROMSCHIZANDRA CHINENSIS

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ANTICOMPLEMENTARY ACTIVITY AND COMPLETE¹³C NMR ASSIGNMENT OF CITROSTADIENOL FROMSCHIZANDRA CHINENSIS