The Role of Widefield Optical Coherence Tomography Angiography in the Diagnosis and Management of Acute Vogt–Koyanagi–Harada Disease

ABSTRACT

Purpose

We explore the choroid vasculature changes of acute Vogt–Koyanagi–Harada (VKH) disease using widefield optical coherence tomography angiography (OCTA).

Methods

In this retrospective, observational, longitudinal study, 16 patients with acute VKH disease (32 eyes, mean age: 42.19 ±13.66 years) were measured using widefield OCTA.

Results

In this study, we first described the multiple dark foci in choriocapillaris and Sattler’s layer in the panoramic montage of the five 12x12mm images in 30 eyes (93.8%) of acute VKH disease. OCTA follow-up in these 30 eyes demonstrated the diminished size and number of these dark foci in choriocapillaris and Sattler’s layer after the initiation of treatment.

Conclusions

Widefield OCTA enables noninvasive identification of characteristics of flow void at the level of superficial choroidal vessels in the acute phase and may be a novel valuable tool for diagnosis and monitoring of disease progression in VKH disease in the future.

KEYWORDS:

• Choriocapillaris layer
• optical coherence tomography
• Sattler’s layer
• Vogt–Koyanagi–Harada disease
• widefield optical coherence tomography angiography

Acknowledgments

The author would like to thank all the participants and the staffs for their valuable contribution to this research.

Authors’ contributions

XYD wrote the main manuscript text. QMS prepared all figures and tables. XYD, XYB, and QMS performed OCTA scans and helped with data collections. QC, GZX, and LC assisted in the manuscript writing and helped reviewed the manuscript. LC performed ophthalmic examinations and clinical assessments of patients.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Ethical approval

This study was approved by the Institutional Review Board (No. 2020119) of Eye and ENT Hospital of Fudan University and conformed to the tenets of the Declaration of Helsinki. Informed consent has been obtained from each patient.

Supplementary material

Supplemental data for this article can be accessed online at https://doi.org/10.1080/09273948.2023.2181186

Correction Statement

This article has been corrected with minor changes. These changes do not impact the academic content of the article.

Additional information

Funding

The authors acknowledge grants from The National Natural Science Foundation of China (No.81870660, LC), Shanghai Science and Technology Foundation (18ZR1405900, LC), Science and Technology Innovation Action Plan of Shanghai Science and Technology Commission (Grant No. 22Y11910500, LC) and Shanghai Municipal Health Committee (20204Y0056, XYD); Shanghai Science and Technology Development Foundation.