MTHFR A1298C polymorphism: a predictor of reduced risk of preeclampsia in Punjab, Pakistan

ABSTRACT

Objectives

This study aimed to investigate the genetic association between MTHFR (A1298C) SNP and preeclampsia (PE) in Punjab, Pakistan.

Methods

A sample of 80 pregnant women (40 healthy pregnant women and 40 with PE) was pooled for genotyping MTHFR A1298C polymorphism by using the tetra-primer amplification refractory mutation system (ARMS) PCR. The Genotypic and allelic assessments were performed using various statistical techniques.

Results

The AC genotype and C allele of MTHFR A1298C were found to be associated with decreased risk of PE (odds ratio [OR]: 0.31, risk ratio [RR]: 0.58, p = 0.01), and (odds ratio [OR]: 0.49, risk ratio [RR]: 0.61, p = 0.04), respectively.

Conclusion

In conclusion, genetic polymorphism A1298C in MTHFR may pose a protective effect in the studied population.

KEYWORDS:

• MTHFR
• polymorphism
• preeclampsia

Acknowledgments

The authors are thankful to all participants of the study.

Disclosure statement

No potential conflict of interest was reported by the authors.

Data availability statement

The data that support the findings of this study are available from the corresponding author, (AY), upon reasonable request.

Supplementary material

Supplemental data for this article can be accessed online at https://doi.org/10.1080/10641955.2023.2187621.

Additional information

Funding

The author(s) reported there is no funding associated with the work featured in this article.