Short stature in small-for-gestational-age offspring born to mothers with hypertensive disorders of pregnancy

ABSTRACT

Objective

To investigate the incidence and risk factors of small-for-gestational age (SGA) short stature at 2 and 3 years of age in SGA offspring born to women with hypertensive disorders of pregnancy (HDP).

Methods

We examined 226 women with HDP whose respective SGA offspring were delivered.

Results

Eighty offspring (41.2%) were diagnosed with SGA short stature. The prematurity before 32 weeks of gestation was the most significant factor for catch-up growth failure.

Conclusion

In SGA offspring born to women with HDP, SGA short stature incidence was high, and the risk factor was prematurity before 32 weeks of gestation.

KEYWORDS:

• Short stature
• catch-up growth
• small-for-gestational age
• premature birth
• hypertensive disorders of pregnancy

Acknowledgments

We acknowledge the Society of Obstetrics and Gynecology in Chugoku and Shikoku that supported this study. The physicians and institutions that cooperated in this study are described below:

Yoko Narai, Department of Obstetrics and Gynecology, Shimane Prefectural Central Hospital, Shimane, Japan

Tetsurou Honda, Department of Obstetrics and Gynecology, Kurashiki Central Hospital, Okayama, Japan

Kenji Kai, Department of Obstetrics and Gynecology, National Hospital Organization Fukuyama Medical Center, Hiroshima, Japan

Katsuhiko Tada, Department of Obstetrics and Gynecology, National Hospital Organization Okayama Medical Center, Okayama, Japan

Takashi Harada, Division of Reproductive-Perinatal Medicine and Gynecologic Oncology, Tottori University Faculty of Medicine, Tottori, Japan

Kazuhisa Maeda, Department of Obstetrics and Gynecology, National Hospital Organization Shikoku Medical Center for Children and Adults, Kagawa, Japan

Ryuhei Nagai, Department of Obstetrics and Gynecology, Kochi Health Sciences Center, Kochi, Japan

Koichiro Shimoya, Department of Obstetrics and Gynecology, Kawasaki Medical School, Okayama, Japan

Emiko Abe, Department of Obstetrics and Gynecology, Ehime Prefectural Central Hospital, Ehime, Japan

Yuko Matsubara, Department of Obstetrics and Gynecology, Ehime University Graduate School of Medicine, Ehime, Japan

Susumu Murata, Department of Obstetrics and Gynecology, Yamaguchi University School of Medicine, Yamaguchi, Japan

Hiroshi Miyoshi, Department of Obstetrics and Gynecology, Hiroshima Prefectural Hospital, Hiroshima, Japan

Consent to participate

The requirement for informed consent was waived due to the retrospective nature of the study.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

The work was supported by the the Society of Obstetrics and Gynecology in the Chugoku and Shikoku areas .