The obesity associated FTO gene polymorphism and the risk of preeclampsia in Iranian women: A case–control study

ABSTRACT

Background

Preeclampsia (PE) is one of the leading disorders in pregnant women with maternal and fetal complications. Obesity is considered an important risk factor for the development of PE. Genetic variations in fat mass and obesity associated (FTO) gene may play a role in the development of PE. This study aimed to investigate the possible association between FTO gene rs9939609 and PE risk in a sample of Iranian pregnant women.

Material and methods

In this case–control study, 312 pregnant women were included, including 128 with PE and 184 without PE. Demographic data and blood samples were obtained from all individuals. The genotyping of rs9939609 polymorphisms was performed by the tetra‐primer amplification refractory mutation system‐polymerase chain reaction (TP‐ARMS‐PCR) method, and the results of TP‐ARMS‐PCR were confirmed using DNA sequencing.

Results

The genotype frequency was 50%, 47.7%, and 2.3% in pregnant patients and 37%, 47.8%, and 15.2% in healthy controls for TT, AT, and AA, respectively. The risk of PE was significantly reduced in the pregnant women having the AA genotype.

Conclusion

Based on the results of the present study, rs9939609 polymorphism in the FTO gene may play a protective role against PE. However, further studies are warranted.

KEYWORDS:

• Preeclampsia
• rs9939609
• genetic polymorphism
• SNP
• FTO

Disclosure statement

The authors declare that they have no competing interests.

Authors’ contributions

GHAT, AF, MFH, AS, and SD designed the study, and carried out the data collection. MSK, JB, MGH, and GHAT were involved in the design of the study, analysis of the data, and critically reviewed the manuscript. This study was conducted at the Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Availability of data and material

The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.

Consent for publication

Institutional consent forms were used in this study.

Ethics approval and consent to participate

The current study was approved by the ethics committee of AJA University of Medical Sciences. IR.AJAUMS.REC.1400.312.

Additional information

Funding

Funding for this study was provided by cancer research center, Shahid Beheshti University of Medical Sciences