ABSTRACT
Background
Previous studies have demonstrated that the triglyceride-glucose (TyG) index is significantly associated with vascular damage. Albuminuria is a marker of hypertension-mediated organ damage (HMOD) and has been linked to a greater risk of cardiovascular disease (CVD). However, the association between the TyG index and albuminuria in patients with hypertension is not clear. This population research focused on subjects with hypertension to investigate the association between an elevated TyG index and albuminuria.
Methods
From September 2019 to November 2019, 789 hypertensive participants were involved in our research. Logistic regression models were performed to estimate the odds ratios (ORs) and 95% confidence intervals (CIs) for albuminuria according to the quartiles of the TyG index.
Results
Multivariate logistic regression analysis revealed that the TyG index was significantly associated with albuminuria. Using the lowest TyG index quartile as the reference, the fully adjusted ORs (95% CIs) for albuminuria for TyG index quartile II, quartile III, and quartile IV were 1.90 (1.17–3.12), 1.81 (1.07–3.07), and 3.46 (2.06–5.91), respectively. The results in the subgroup analysis were similar to the main analyses except for the smokers. Restricted cubic spline curves based on logistic regression models evaluated the linear association between the TyG index and albuminuria (P for nonlinear = 0.831).
Conclusion
The TyG index was positively associated with albuminuria among hypertensive participants.
Acknowledgments
None.
Disclosure statement
No potential conflict of interest was reported by the author(s).
Author contributions
Yunfan Tian performed the data analyses and wrote the manuscript. Jingyu Sun contributed significantly to analysis and manuscript preparation. Ming Qiu and Yan Lu helped perform the analysis with constructive discussions. Xuesong Qian and Wei Sun contributed to refining the ideas and finalizing this paper. Xiangqing Kong contributed to the conception of the study.
Ethical approval
Our study protocol was approved by the Ethics Committee of the First Affiliated Hospital of Nanjing Medical University (2019-SR-097). Informed consent was obtained from all individual participants included in our study.
Supplementary material
Supplemental data for this article can be accessed online at https://doi.org/10.1080/10641963.2022.2150204.