Computed tomography myocardial perfusion imaging of patients with left ventricular hypertrophy in hypertension: A retrospective study

ABSTRACT

Objective

Left ventricular hypertrophy (LVH) is a strong predictor of adverse cardiovascular outcomes including heart failure. This study evaluated characteristics and the influencing factors of computed tomography myocardial perfusion imaging (CT-MPI) of patients with LVH in hypertension.

Methods

A total of 65 patients with stable chest pain and confirmed coronary stenosis <50% by coronary computed tomography angiography (cCTA) from September 2019 to February 2021 were recruited. According to the results of echocardiography, patients were divided into the LVH group (n = 33) and control group (patients without LVH, n = 32). The general data of all study subjects were collected, and the body mass index (BMI) and body surface area (BSA) were calculated. Myocardial blood flow (MBF), myocardial blood volume (MBV), and echocardiographic parameters were recorded. Spearman correlation analyses were conducted to analyze the relationship between MBF, MBV, and echocardiographic parameters.

Results

The LVH group had significantly higher left ventricular end diastolic distance (LVEDd), septal wall thickness diastole (SWTd), and post wall thickness diastole (PWTd) than the control group, resulting in higher left ventricular mass index (LVMI) (P < .05). The LVH group showed significantly lower MBF than the control group (P < .05), but there was no significant difference in MBV between two groups (P > .05). Spearman correlation analysis demonstrated that MBF was negatively correlated with SWTd and LVMI (P < .05).

Conclusions

CT-MPI, as a new noninvasive modality to evaluate myocardial perfusion in hypertensive patients, revealed that MBF is reduced in patients with LVH, while MBV remains unchanged. In hypertensive patients, decreased MBF is significantly correlated with increased LVMI.

KEYWORDS:

• computed tomography
• myocardial perfusion imaging
• left ventricular hypertrophy
• hypertension
• MBF

Abbreviations

CT-MPI: computed tomography myocardial perfusion imaging; cCTA: coronary computed tomography angiography; LVH: left ventricular hypertrophy; BMI: body mass index; BSA: body surface area; MBF: Myocardial blood flow; MBV: myocardial blood volume; LVEDd: left ventricular end diastolic distance; SWTd: septal wall thickness diastole; PWTd: post wall thickness diastole; LVMI: left ventricular mass index; CFR: coronary flow reserve; PET: positron emission tomography; SPECT: single-photon emission computed tomography; MRI: magnetic resonance imaging; CT: computed tomography; CT-MPI: computed tomography myocardial perfusion imaging; SBP: systolic blood pressure; DBP: diastolic blood pressure; HR: heart rate; BMI: body mass index; BSA: body surface area; LDL-C: low-density lipoprotein cholesterol; AHA: American Heart Association; ROI: region of interest; MBV: myocardial blood volume; TDC: time density curve; MACE: major adverse cardiovascular events.

Declarations

Ethics approval and consent to participate

The study was approved by the Daqing Oilfield General Hospital. Informed consent was obtained from all participants.

Disclosure statement

No potential conflict of interest was reported by the authors.

Availability of data and material

All data generated or analyzed during this study are included in this. Further enquiries can be directed to the corresponding author.

Author contributions

XW and FY are responsible for the guarantor of integrity of the entire study, study concepts & design, definition of intellectual content, literature research, clinical studies, experimental studies, data acquisition & analysis, statistical analysis, manuscript preparation & editing; LL Sun is responsible for the guarantor of integrity of the entire study, study concepts & design, experimental studies, statistical analysis, manuscript review. All authors read and approved the final manuscript

Additional information

Funding

The authors reported there is no funding associated with the work featured in this article.