Association between CBS gene T833C, G919A and 844ins68 polymorphisms in the 8th exon region and coronary artery disease: a meta-analysis

ABSTRACT

Background

Several studies indicate that the cystathionine β-synthase (CBS) gene T833C, G919A and 844ins68 polymorphisms in the 8th exon region may be correlated with coronary artery disease (CAD) susceptibility, but the results have been inconsistent and inconclusive. Thus, a meta-analysis was conducted to provide a comprehensive estimate of these associations.

Methods

On the basis of searches in the PubMed, EMBASE, Cochrane Library, Wanfang, VIP, and CNKI databases, we selected 14 case – control studies including 2123 cases and 2368 controls for this meta-analysis. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated accordingly using a fixed-effect or random-effect model.

Results

The results indicated an increased risk between the CBS T833C gene polymorphisms and susceptibility to CAD under the dominant model (CC+CT vs. TT: OR = 1.92, 95% CI: 1.11 ~ 3.32), recessive model (CC vs. CT+TT: OR = 1.88, 95% CI: 1.17 ~ 3.03), and homozygous model (CC vs. TT: OR = 2.46, 95% CI: 1.04 ~ 5.83). In these three genetic models, no significant association was identified for CBS G919A (AA+AG vs. GG: OR = 1.48, 95% CI: 0.45 ~ 4.82),(AA vs. AG+GG: OR = 1.58, 95% CI: 0.93 ~ 2.70),(AA vs. GG: OR = 1.66, 95% CI: 0.40 ~ 6.92) or CBS 844ins68 (II+ID vs. DD: OR = 1.04, 95% CI: 0.80 ~ 1.35),(II vs. ID+DD: OR = 1.09, 95% CI: 0.51 ~ 2.36),(II vs. DD: OR = 1.10, 95% CI: 0.51 ~ 2.39).

Conclusions

This meta-analysis suggests that the CBS T833C gene polymorphism is significantly associated with the risk of CAD and it shows a stronger association in Asian populations. Individuals with the C allele of the CBS gene T833C polymorphism might be particularly susceptible to CAD.

KEYWORDS:

• Cystathionine β-synthase
• polymorphism
• coronary artery disease
• meta-analysis

Disclosure statement

No potential conflict of interest was reported by the author(s).

Author’ contributions

Conceptualization: ZJ Z, YH G, LM.

Data curation: ZJ Z, YH G, LM, YM M, KY Y.

Formal analysis: RT C, JL L, KY Y.

Fundingacquisition: ZJZ.

Investigation: ZJ Z, YH G, LM, RT C, JL L.

Methodology: ZJ Z, YH G.

Supervision: ZJ Z.

Writing – original draft: ZJ Z, YHG.

Writing – review& editing: ZJ Z, YH G, LM.

Acknowledgments: ZJ Z, YH G, LM, KY Y, YM M, RT C, JL L.

Consent for publication

All data relevant to the study are included in the article or uploaded as online supplementary information.

Ethics approval and consent to participate

Ethical approval was not necessary for this work.

Supplementary material

Supplemental data for this article can be accessed online at https://doi.org/10.1080/10641963.2024.2328147

Additional information

Funding

This work was supported by a grant from the Natural Science Foundation of Gansu Province (1606RJZA168).