Relationship between triglyceride-glucose index and new-onset hypertension in general population–a systemic review and meta-analysis of cohort studies

ABSTRACT

Background

The triglyceride-glucose (TyG) index is an alternative biomarker for insulin resistance that may be connected to incident hypertension. We performed the meta-analysis to clarify the connection between TyG index and new-onset hypertension in the general population.

Methods

We recruited cohort studies that assessed the association between TyG index and the risk of hypertension in the general population by searching the databases of PubMed, EMBASE, and Web of Science (SCI) from their inception dates until July 18, 2023. The primary focus of the study was on the hazard ratio (HR) of hypertension in relation to the TyG index. The adjusted HR and 95% confidence interval (CI) were pooled by the random-effects model. Subgroup analyzes stratified by age, sex, follow-up duration, body mass index (BMI), and ethnicity were performed.

Results

Our analysis comprised 35 848 participants from a total of 7 cohort studies. The highest TyG index category showed a 1.51-fold greater risk of hypertension in the general population than the lowest category (HR = 1.51, 95%CI 1.26–1.80, p < .001). Consistent results were obtained using sensitivity analysis by eliminating one trial at a time (p values all <0.001). Subgroup analysis showed that the relationship between TyG index and hypertension was not substantially influenced by age, sex, BMI, participant ethnicity, and follow-up times (P for interaction all >0.05).

Conclusions

Elevated TyG index significantly increased the risk of new-onset hypertension in the general population. It is necessary to conduct the research to clarify the probable pathogenic processes underpinning the link between the TyG index and hypertension.

KEYWORDS:

• Hypertension
• triglyceride-glucose index
• insulin resistance
• cohort studies
• meta-analysis

Disclosure statement

No potential conflict of interest was reported by the author(s).

Accessibility of data

The datasets used in the present investigation may be obtained from the corresponding author upon a reasonable request.

Authors’ contributions

CQ.Y and PJ.W contributed to the creation of the research design. CQ.Y and Y.S were actively engaged in the process of data collecting and analysis. CQ.Y contributed to the writing of the text. The manuscript modifying involved the participation of YS and PJW. The article was reviewed by all of the writers.

Additional information

Funding

The author(s) reported that there is no funding associated with the work featured in this article.