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ABSTRACT
Keratoprosthesis (K-Pro) implantation and postoperative recovery often lead to severe ocular infections called keratoprosthesis-associated infections (KPAI). Antibiotics are commonly used; however, prolonged antibiotic use can lead to bacterial resistance and disrupt microbial balance in the eye. Borneol provides possibilities for developing antibiotic-independent antimicrobial K-Pro. Therefore, the development of an antibiotic-independent self-antimicrobial K-Pro is crucial for postoperative management. Herein, electrospinning technology was employed to fabricate a soluble borneol-based antibacterial coating on K-Pro surfaces for postoperative management of keratoprosthesis implantation. The modified K-Pro exhibited a distinctive nanofibrous morphology (100% borneol release ratio within 125 min), surface antibacterial properties (Escherichia coli: 2%, Staphylococcus aureus: 6%), biocompatibility, and negligible cytotoxicity towards epithelial cells. This study aimed to explore the potential application of camphor-based electrospun coatings in the field of K-Pro infection resistance, thereby providing novel strategies and material foundations for the effective postoperative management of KPAI.
Author contributions
Y.L. and T.W. contributed equally to this work. Conceptualisation: X.B., T.W., and Y.L.; Methodology: X.B., T.W., and Y. L.; Investigation: K.Y. and X.B.; Resources: Y.L.; Data Calculation: X.B.; Writing – Original Draft Preparation: X.B.; Writing – Review and Editing: X.B., T.W., and Y.L.; Visualisation: X.B.; Supervision: X.B.; Project Administration: X.B.; Funding Acquisition: T.L. All authors have read and agreed to the published version of the manuscript.
Disclosure statement
No potential conflict of interest was reported by the authors.