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ABSTRACT
The synthesized Ag-SeO2-doped (Fu) nanocomposites are novel therapeutic approaches against multidrug-resistant bacteria. The present study explores the synthesis, characterization, and evaluation of the antibacterial, antioxidant, and in vivo cytotoxic activities of novel nanocomposites. The distinguishing characteristics of Ag-Se/Fu nanocomposites were revealed through the use of UV-visible spectroscopy, EDX, and FTIR analysis. The result of the SEM micrograph shows that Ag-Se NPs and Fu nanocomposites, with average nanoparticle diameters that vary from 97.28 ± 7.14 nm, display spherical shapes. It was found that the potency of antioxidant and antimicrobial agents against Enterococcus faecalis, Klebsiella pneumonia, Escherichia coli, and Methicillin-resistant Staphylococcus aureus (MRSA). Moreover, the cytotoxicity assay indicates the nanocomposite has shown a survival rate of 98% in zebrafish embryos at 150 mg/mL. Compared to the control group, the embryos from the nanocomposite group had normal morphology, which is evidence of its safety and effectiveness. The results of this research reveal a promising strategy for multidrug-resistant bacteria with less cytotoxicity.
Acknowledgments
The authors express their sincere appreciation to the researchers supporting project number (RSP2024R228) King Saud University, Riyadh, Saudi Arabia. Dr. Saravanan Muthupandian acknowledges to ICMR, Govt. of India for the Financial support IIRP-2023-8109.
Author contribution
Conception and design: M.S & T.A; analysis and interpretation of the data: M.S, S.B.V, P.G.S & B.R; the drafting of the paper: M.S, S.S, & M.A.A, revising it critically for intellectual content; M.S, T.A, S.S & B.R. All author are approve the final version manuscript.
Disclosure statement
No potential conflict of interest was reported by the author(s).