Bio fabrication of Fe₂O₃ NPs and their analgesia efficiency for post-operative epidural anaesthetic applications- study of chronic inflammatory pain model in mice

ABSTRACT

The current study reported the synthesis of ferric oxide nanoparticles (Fe₂O₃ NPs) using the leaf extract of Amaranthus spinosus Linn and studied their analgesia efficiency in chronic inflammatory pain model in mice. X-RD, TEM results showed that the spherical Fe₂O₃ NPs having rhombohedral crystalline structure with an average particle size of 10 nm. Additionally, inflammatory pain models were designed through FCA injection on the CD1 mice hind paw with various Fe₂O₃ NPs doses and analgesic behaviour was monitored. The prepared Fe₂O₃ NPs showed a dose-dependent analgesic activity with considerable decrease in inflammatory cells, ROS production and pro-inflammatory markers. Additionally, the expression of enzymes responsible for ROS production were decreased. The outcomes of present work revealed the local administration of Fe₂O₃ NPs caused the substantial analgesia through reduction of pro-inflammatory signalling and inflammatory cellular infiltration along with micro-environmental free radical scavenging in mouse inflammatory pain model.

KEYWORDS:

• Fe₂O₃ NPs
• analgesia
• pain
• mouse

Acknowledgments

Authors are thankful to Affiliated Hospital of Hubei University of Arts and Science for their support to do this research.

Disclosure statement

No potential conflict of interest was reported by the author(s).