Phenolics with Anti-HSV and Anti-HIV Activities from Artocarpus gomezianus., Mallotus pallidus., and Triphasia trifolia.

K. Likhitwitayawuid Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand

B. Supudompol Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand

B. Sritularak Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand

V. Lipipun Department of Microbiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand

K. Rapp Veterans Affairs Medical Center and Department of Pediatrics, School of Medicine, Emory University, Decatur, Georgia, USA

R.F. Schinazi Veterans Affairs Medical Center and Department of Pediatrics, School of Medicine, Emory University, Decatur, Georgia, USA

Abstract

A total of 25 phenolic compounds were studied for their inhibitory effects against herpes simplex virus (HSV)-1, HSV-2, and human immunodeficiency virus (HIV)-1. These include five flavonoids (1–5) and two dimeric stilbenes (6,7) from Artocarpus gomezianus. Wall. ex tréc., five phloroglucinol derivatives (8–12) from Mallotus pallidus. (Airy Shaw) Airy Shaw, and 13 courmarins (13–25) from Triphasia trifolia. (Burm.f.) P. Wilson. The data obtained in this study suggest the bis-hydroxyphenyl structure as a potential target for anti-HSV and HIV drugs development.

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Phenolics with Anti-HSV and Anti-HIV Activities from Artocarpus gomezianus., Mallotus pallidus., and Triphasia trifolia.

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Phenolics with Anti-HSV and Anti-HIV Activities from Artocarpus gomezianus., Mallotus pallidus., and Triphasia trifolia.

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