Antinociceptive, anti-inflammatory and antipyretic properties of an aqueous extract of Corchorus capsularis leaves in experimental animal models

Abstract

The present study was carried out to establish the antinociceptive, anti-inflammatory and antipyretic properties of an aqueous extract of jute plant leaves, Corchorus capsularis L. (Tiliaceae), in experimental animals. The antinociceptive activity was measured using the abdominal constriction, hot plate and formalin tests, while the anti-inflammatory and antipyretic activities were measured using the carrageenan-induced paw edema and brewer’s yeast-induced pyrexia tests, respectively. The extract, obtained after 72 h soaking of the air-dried leaves in distilled water, freeze-drying for 72 h and then prepared in dosages of 11.57, 57.85, and 115.7 mg/kg, was administered subcutaneously (10 ml/kg) 30 min prior to subjection to the above mentioned assays. The extract was found to exhibit significant (antinociceptive, anti-inflammatory and anti-pyretic, activities in a dosage-independent manner. In conclusion, the aqueous extract of C. capsularis possesses antinociceptive and antipyretic activities and supports the previous claim of its traditional use to treat various ailments.

Keywords::

• Corchorus capsularis
• aqueous extract
• antinociceptive
• anti-inflammatory
• antipyretic
• dosage-independent

Acknowledgements

This study was supported by a research grant from the Universiti Industri Selangor, Malaysia (Project Code Number: 03013; Project Vote Number: 3090103013). The authors would like to thank Universiti Putra Malaysia for their facilities.

Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.