Antioxidative activity of alcohol-soluble fullerene derivative

Abstract

To utilize the radical scavenging property of fullerene (C₆₀), hydrophilic poly(ethylene glycol) (PEG) was chemically attached by Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC). The resulting C₆₀-PEG derivatives were soluble in methanol when the molecular weight of PEG was 5,000. The antioxidative activity was evaluated for the alcohol-soluble C₆₀ derivative. The C₆₀-PEG has sufficient antioxidative activity with the β-carotene-attributed chromaticity of 76% for the C₆₀-PEG derivative (9.96 mM). Further chemical modification will produce water-soluble fullerenes with higher antioxidative activities.

Keywords:

• Antioxidant
• click chemistry
• cycloaddition
• fullerene
• poly(ethylene glycol)

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was partly supported by the Kose Cosmetology Research Foundation.