https://orcid.org/0000-0003-0369-5269
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ABSTRACT
The RNA-targeting CRISPR-Cas13 system has enabled precise engineering of endogenous RNAs, significantly advancing our understanding of RNA regulation and the development of RNA-based diagnostic and therapeutic applications. This review aims to provide a summary of Cas13-based RNA targeting tools and applications, discuss limitations and challenges of existing tools and suggest potential directions for further development of the RNA targeting system.
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Disclosure statement
No potential conflict of interest was reported by the author(s).
Additional information
Funding
X.W. is supported by NIH grants [1DP2GM140977 and 1R01HL171664] and Pershing Square Sohn Cancer Research Alliance. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.