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ABSTRACT
The sebaceous gland, long considered an evolutionary relic with little-to-no physiological relevance in humans, has emerged in recent decades as a key orchestrator and contributor to many cutaneous functions. In addition to the classical physico-chemical barrier function of the skin against constant environmental challenges, a more novel, neuro-immune modulatory role has also emerged. As part of the complex intercellular communication network of the integumentary system, the sebaceous gland acts as a “relay station” in the skin for many endocrine factors. This review aims to offer a comprehensive overview of endocrine effects and subsequent interactions on this much maligned mini-organ.
Disclosure of potential conflicts of interest
No potential conflicts of interest were disclosed.
Additional information
Funding
This work was supported by the New National Excellence Program of the Ministry of Human Capacities; and National Research, Development and Innovation Office under Grants 120187, 121360, GINOP-2.3.2-15-2016-00050. BIT is a recipient of the János Bolyai research scholarship of the Hungarian Academy of Sciences.