YAP1 Rearrangement in Parotid Sclerosing Mucoepidermoid Carcinoma

ABSTRACT

Objective

This study investigates to investigate Yes-associated protein 1 (YAP1) rearrangement status in a six-case of sclerosing mucoepidermoid carcinoma (SMEC) series with reference to 20 conventional mucoepidermoid carcinomas.

Method

A retrospective analysis was conducted on a cohort of patients diagnosed with SMEC from 2018 to 2022. The presence of YAP1 rearrangement was determined using fluorescence in situ hybridization (FISH) analysis targeting the YAP1 gene located at 11q22.1-q22.2. Clinical data, including patient outcomes, were collected and analyzed. Next-generation sequencing (NGS) was performed to identify the fusion partner involved in the YAP1 rearrangement.

Results

A total of six cases of SMEC were included in the study, of YAP1::MAML2 fusion was detected and five cases showed YAP1 rearrangement on FISH testing.

Conclusion

YAP1 alteration may explain the indolent nature of SMECs, especially in cases with low cellularity. Further studies incorporating NGS analysis are warranted to unravel the fusion partner associated with YAP1 rearrangement, providing a deeper understanding of the molecular mechanisms underlying the positive outcomes observed in these patients.

KEYWORDS:

• YAP1
• sclerosing mucoepidermoid carcinoma
• FISH
• salivary gland cancers

Disclosure Statement

No potential conflict of interest was reported by the author(s).

Supplementary material

Supplemental data for this article can be accessed online at https://doi.org/10.1080/19424396.2023.2283225

Author Contributions

All contributed equally. For more information on using the automatic grader, please conctact the corresponding author.

Informed Consent Statement

All cases were anonymous.

Institutional Review Board Approval

Obtained.

Additional information

Funding

This research received no external funding

Notes on contributors

Sherif Y. El-Nagdy

Sherif Y. El-Nagdy is a Professor of Oral Pathology at Mansoura University, Egypt, and Horus University in Egypt. He specializes in diagnosing salivary gland carcinomas and odontogenic lesions, with a specific focus on advancing understanding regarding oncogenetic changes of odontogenic lesions in non-odontogenic topographies.

Pushparaja Shetty

Pushparaja Shetty is a Professor in the Department of Oral Pathology and Microbiology at Nitte University, holding both an MDS and a PhD. His research interests center around exploring atypical morphological presentations of oral diseases, aiming to improve the recognition and investigation of rare lesions.

Bacem Abdullah

Basem Abdullah is an Assistant Lecturer in Oral Pathology while pursuing a PhD in the same domain. His research primarily delves into molecular pathology and bioinformatics, aiming to integrate advanced technological approaches into proposing diagnostic algorithms and offering biomedical software applications.

Shahram Sabeti

Shahram Sabeti is a Board-certified Clinical Anatomical Pathologist and an Associate Professor of Pathology at Shahid Beheshti University of Medical Sciences in Iran. His research interests encompass head and neck anatomic pathology and molecular pathology, with a focus on advancing diagnostic techniques and genetic understanding in these areas.