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ABSTRACT
During the last 10 years, the formulation of drugs as nanocrystals has rapidly evolved into a mature drug delivery strategy, with currently five products on the market. The major characteristic of these systems is the rapid dissolution velocity, enabling bioavailability enhancement after oral administration. Albendazole, a lipophilic anthelmintic drug, belongs to biopharmaceutical classification system type II: low aqueous solubility and bioavailability and high permeability. This study describes the bioefficacy of an albendazole nanosuspension tablet achieved by high-pressure homogenization. The aim was to obtain a stable nanosuspension with an increased drug saturation solubility and dissolution velocity. Pharmacokinetics of optimized albendazole nanosuspensions after oral administration to rats was studied. Bioavailability of albendazole nanosuspensions were 2–3-fold compared with that of market product. These results indicate the potential of nanosuspension in improvement of oral bioavailability of lipophilic drugs such as albendazole.
acknowledgements
Facilities were obtained from Torrent Research Center, Ahmedabad, High Security Animal Disease Laboratory, Bhopal, and Central Food Technological Research Institute, Mysore.