LncRNAs, nuclear architecture and the immune response

ABSTRACT

Long noncoding RNAs (LncRNAs) are key regulators of gene expression and can mediate their effects in both the nucleus and cytoplasm. Some of the best-characterized lncRNAs are localized within the nucleus, where they modulate the nuclear architecture and influence gene expression. In this review, we discuss the role of lncRNAs in nuclear architecture in the context of their gene regulatory functions in innate immunity. Here, we discuss various approaches to functionally characterize nuclear-localized lncRNAs and the challenges faced in the field.

KEYWORDS:

• Chromatin
• innate immunity
• long noncoding RNAs
• macrophages
• nucleus

Disclosure statement

S. C. is a paid consultant for NextRNA Therapeutics.

Author contributions

C. M., C. F. A., and S. C. were involved in the conceptual design, writing, and reviewing of the manuscript.

Data availability statement

No new data were generated for this study. All referenced data are available in cited publications.

Additional information

Funding

S. C. was funded by [R35GM137801] from NIGMS. C. M. was funded by a supplemental award to [R35GM137801] from NIGMS. C. F. A. was supported by [R35GM137801] and [K12GM139185] from the NIH.