Oxidative stress response: a critical factor affecting the ecological competitiveness of Streptococcus mutans

ABSTRACT

Oral microecological balance is closely associated with the development of dental caries. Oxidative stress is one of the important factors regulating the composition and structure of the oral microbial community. Streptococcus mutans is linked to the occurrence and development of dental caries. The ability of S. mutans to withstand oxidative stress affects its survival competitiveness in biofilms. The oxidative stress regulatory mechanisms of S. mutans include synthesis of reductase, regulation of metal ions uptake, regulator PerR, transcription regulator Spx, extracellular uptake of glutathione, and other related signal transduction systems. Here, we provide an overview of how S. mutans adapts to oxidative stress and its influence on oral microecology, which may offer novel options to investigate the cariogenic mechanisms of S. mutans in the oral microenvironment, and new targets for the ecological prevention and treatment of dental caries.

KEYWORDS:

• Streptococcus mutans
• oxidative stress
• hydrogen peroxide
• oral microecology
• dental caries

Acknowledgments

This work was supported by the National Natural Science Foundation of China (82101002), Project of Science and Technology Department of Sichuan Province (2022NSFSC1359, 2022-901), and the Research Funding from West China Hospital of Stomatology Sichuan University (RCDWJS2021-16).

Disclosure statement

No potential conflict of interest was reported by the authors.

Author contributions

XC and JN drafted the manuscript. XX and XZ edited and added valuable insights to the manuscript. All authors approved the final manuscript and agreed to be accountable for all aspects of the work.

Additional information

Funding

The work was supported by the the National Natural Science Foundation of China [82101002]; the Research Funding from West China Hospital of Stomatology Sichuan University [RCDWJS2021-16]; Project of Science and Technology Department of Sichuan Province [2022NSFSC1359].