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ABSTRACT
The burden of fungal infections on human health is increasing worldwide. Aspergillus, Candida, and Cryptococcus are the top three human pathogenic fungi that are responsible for over 90% of infection-related deaths. Moreover, effective antifungal therapeutics are lacking, primarily due to host toxicity, pathogen resistance, and immunodeficiency. In recent years, nanomaterials have proved not only to be more efficient antifungal therapeutic agents but also to overcome resistance against fungal medication. This review will examine the limitations of standard antifungal therapy as well as focus on the development of nanomaterials.
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Disclosure statement
No potential conflict of interest was reported by the author(s).
Additional information
Funding
This work was supported by the National Natural Science Foundation of China (82202543, 82072257, 82102416), Ministry of Science and Technology of China (2022YFC2504800), Science and Technology Commission of Shanghai Municipality (20DZ2272000 and 21410750500), Shanghai Municipal Health Commission (shslczdzk01001), and Chinese Academy of Engineering (2022-HZ-10-3).