COVID-19 vaccines: Immune correlates and clinical outcomes

Shant H. Mahrokhiana Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA;b Department of Medicine, Tufts University School of Medicine, Boston, MA, USA

https://orcid.org/0000-0003-4094-8739 View further author information

Lisa H. Tostanoskia Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USAView further author information

Samuel J. Vidala Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA;c Division of Infectious Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USAView further author information

Dan H. Baroucha Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA;d Department of Medicine, Harvard Medical School, Boston, MA, USA;e Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USACorrespondence[email protected]

https://orcid.org/0000-0001-5127-4659 View further author information

ABSTRACT

Severe disease due to COVID-19 has declined dramatically as a result of widespread vaccination and natural immunity in the population. With the emergence of SARS-CoV-2 variants that largely escape vaccine-elicited neutralizing antibody responses, the efficacy of the original vaccines has waned and has required vaccine updating and boosting. Nevertheless, hospitalizations and deaths due to COVID-19 have remained low. In this review, we summarize current knowledge of immune responses that contribute to population immunity and the mechanisms how vaccines attenuate COVID-19 disease severity.

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COVID-19 vaccines: Immune correlates and clinical outcomes

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COVID-19 vaccines: Immune correlates and clinical outcomes

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