Global research trends in CAR-T cell therapy for solid tumors: A comprehensive visualization and bibliometric study (2012–2023)

ABSTRACT

CAR-T cell therapy has emerged as a significant approach for the management of hematological malignancies. Over the past few years, the utilization of CAR-T cells in the investigation and treatment of solid tumors has gained momentum, thereby establishing itself as a prominent area of research. This descriptive study involved the retrieval of articles about CAR-T cell therapy for solid tumors from the Web of Science Core Collection (WoSCC) database. Subsequently, bibliometric analysis and knowledge map analysis were conducted on these articles. The field under consideration is currently experiencing a period of swift advancement, as evidenced by the escalating number of publications in this domain each year. The United States holds an indisputable position as the foremost leader in this particular field, with the University of Pennsylvania emerging as the most active institution. The authors with the highest citation frequency and co-citation frequency are Carl H. June and Shannon L. Maude, respectively. The research hotspots in this field mainly focus on five aspects. Additionally, 10 emerging themes were identified. This study undertakes a comprehensive, systematic, and objective analysis and exploration of the field of CAR-T cell treatment for solid tumors, utilizing bibliometric methods. The findings of this study are expected to serve as a valuable reference and enlightenment for future research endeavors in this particular domain.

KEYWORDS:

• CAR-T cells
• solid tumors
• bibliometric
• knowledge-map
• hotspots
• emerging topics

Author contributions

L.M.: Writing-Original draft preparation, manuscript, investigation, and figure preparation. J.Z.: manuscript, investigation, and figure preparation. W.X.: Investigation and figure preparation. Q.Q.: Investigation. G.Z.: Investigation. Q.Y. Investigation. Y.L. Investigation. H.Z.: Methodology, Supervision. C.S.: Methodology, Supervision. W.W.: Conceptualization, Methodology, Supervision.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Data availability statement

The original contributions presented in the study are included in the article/supplementary material. Further inquiries can be directed to the corresponding authors.

Supplementary material

Supplemental data for this article can be accessed on the publisher’s website at https://doi.org/10.1080/21645515.2024.2338984.

Additional information

Funding

The author(s) reported there is no funding associated with the work featured in this article.