Paradoxes and wonders of intrinsic disorder: Complexity of simplicity

Vladimir N. UverskyDepartment of Molecular Medicine and USF Health Byrd Alzheimer Research Institute, Morsani College of Medicine, University of South Florida, Tampa, FL, USA;Faculty of Science, Biology Department, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia;Institute for Biological Instrumentation, Russian Academy of Sciences, Pushchino, Moscow Region, Russia;Laboratory of Structural Dynamics, Stability and Folding of Proteins, Institute of Cytology, Russian Academy of Sciences, St. Petersburg, RussiaCorrespondence[email protected]

ABSTRACT

At first glance it may seem that intrinsically disordered proteins (IDPs) and IDP regions (IDPRs) are simpler than ordered proteins and domains on multiple levels. However, such multilevel simplicity equips these proteins with the ability to have very complex behavior.

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Disclosure of potential conflicts of interest

No potential conflicts of interest were disclosed.

Acknowledgments

I am thankful to Alexey Uversky for careful reading and editing this manuscript.

Funding

This work was supported in part by a grant from the Russian Science Foundation RSCF № 14–24–00131.

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Paradoxes and wonders of intrinsic disorder: Complexity of simplicity

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Paradoxes and wonders of intrinsic disorder: Complexity of simplicity

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Disclosure of potential conflicts of interest

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