Abstract
Pouteria caimito is a commercially valuable tropical fruit tree and has medicinal effects in Brazilian folklore. In this thesis, thirteen compounds were isolated for the first time from the fruit of P. caimito by ethanol extraction and various chromatographic column chromatography methods. The thirteen compounds were identified by NMR, HR-ESI-MS and various physicochemical data to contain nine triterpenoids. The results of activity screening experiments showed that compounds 2, 3 and 5 exhibited anti-inflammatory activity, while most of the triterpenoids exhibited anti-RSV, and anti-HSV activity to varying degrees. Based on these results, the content of compound 5 was determined due to its good pharmacological activity to be 13.3250 mg/kg in the fresh fruit. This study scientifically demonstrated the health benefits of consuming P. caimito fruits and also provided new ideas for further development and utilization of P. caimito. It not only has good potential as an anti-inflammatory or antiviral functional food but also can be considered a natural source of triterpenoids.
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Guo-Cai Wang
Guo-Cai Wang is a researcher at College of Pharmacy, Jinan university, His research interests include natural products chemistry, development of new methods in isolation, structure elucidation, and target identification of bioactive natural products. material basis of medicinal efficacy of traditional Chinese medicine and research on natural active ingredients and their pharmacological activities.