CeO₂/ZnO nanocomposite-modified glassy carbon electrode as an enhanced sensing platform for sensitive voltammetric determination of norepinephrine

Abstract

In this study, a CeO₂/ZnO nanocomposite-modified glassy carbon electrode (CeO₂/ZnO/GCE) was fabricated as a voltammetric sensor for the determination of norepinephrine. The oxidation of norepinephrine occurred at a potential of about 260 mV less positive than that of the unmodified GCE, under optimum pH of 7.0. The modified electrode exhibited excellent electrocatalytic activity for the oxidation of norepinephrine. The differential pulse voltammetric (DPV) response in solutions with a neutral pH value increased linearly in the concentration range of 0.5 μM to 800.0 μM norepinephrine, with a low detection limit (LOD) of 0.1 μM. The CeO₂/ZnO/GCE sensor was successfully applied for the detection of norepinephrine in norepinephrine ampule and urine samples.

Keywords:

• Norepinephrine
• CeO₂/ZnO nanocomposite
• voltammetric sensor
• modified electrode

Disclosure statement

No potential conflict of interest was reported by the authors.