Synthesis and characterisation of CuO nanoparticle: its electrochemical paracetamol sensor activity and substituted-2-aminothiophene synthesis applications

Abstract

In the present work, the synthesised nanoparticle was examined by multiple characterisation techniques for physico-chemical, surface-morphological, elemental, and optical properties. These structural parameters of achieved nano-catalyst was studied by using P-XRD, SEM-EDAX, FT-IR and Energy band gap techniques. The electrochemical analysis of synthesised CuO nanoparticle modified with carbon paste was investigated using 0.1 M KCl under different scan rates of 0.01–0.05 V/s. The sensing activity of prepared material was performed for Paracetamol medicine at concentration 1–5 mM in the potential range of–1.0 V to + 1.0 V using cyclic voltametric analysis. Microwave accelerated synthesis of substituted-2-aminothiophene by a 3-component (acetophenone, malononitrile and elemental sulphur) one pot Gewald reaction using low-cost nano-catalyst (CuO nanoparticle) to perform for chemical reactions. The synthesised compounds were confirmed by FT-IR, ¹HNMR, ¹³C NMR and Mass spectral techniques. The antibacterial activity was examined using Bacillus cereus (gram positive) & Ciprofoxin (gram negative) organism and evaluated antifungal activities using Candida albicans (gram positive) & Itraconazole (gram negative) organism for prepared organic compounds tested under agar diffusion method. Molecular docking studies were discussed for both carboxylate and carbonitrile derivatives at the active site of the bacterial protein GlcN-6-P synthase. Green chemistry encourages the design of synthetic processes that minimise the use and generation of hazardous substances.

Keywords:

• Substituted-2-aminothiophene
• gewald reaction
• microwave accelerated organic synthesis
• nano-catalyst

Aknowledgement

Dr. Ravishankar shastri P R and Rathnamma D, thanks for financial support and providing necessary facilities and thankful to research guide Dr. Suresha Kumara T H, department of chemistry, UBDT college of engineering for kind support to carry out this research work.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Data availability materials

The data available on request from the authors.