Development of novel benzotriazines for drug discovery

Moorthy SS Palanki TargeGen, Inc., 9380 Judicial Drive, CA 92121, San Diego, USA +1 858 678 0760; +1 858 678 0762; [email protected]

Jianguo Cao TargeGen, Inc., 9380 Judicial Drive, CA 92121, San Diego, USA +1 858 678 0760; +1 858 678 0762; [email protected]

Chun P Chow TargeGen, Inc., 9380 Judicial Drive, CA 92121, San Diego, USA +1 858 678 0760; +1 858 678 0762; [email protected]

Elena Dneprovskaia TargeGen, Inc., 9380 Judicial Drive, CA 92121, San Diego, USA +1 858 678 0760; +1 858 678 0762; [email protected]

Chi Ching Mak TargeGen, Inc., 9380 Judicial Drive, CA 92121, San Diego, USA +1 858 678 0760; +1 858 678 0762; [email protected]

Andrew McPherson TargeGen, Inc., 9380 Judicial Drive, CA 92121, San Diego, USA +1 858 678 0760; +1 858 678 0762; [email protected]

Ved P Pathak TargeGen, Inc., 9380 Judicial Drive, CA 92121, San Diego, USA +1 858 678 0760; +1 858 678 0762; [email protected]

Joel Renick TargeGen, Inc., 9380 Judicial Drive, CA 92121, San Diego, USA +1 858 678 0760; +1 858 678 0762; [email protected]

Richard Soll TargeGen, Inc., 9380 Judicial Drive, CA 92121, San Diego, USA +1 858 678 0760; +1 858 678 0762; [email protected]

Binqi Zeng TargeGen, Inc., 9380 Judicial Drive, CA 92121, San Diego, USA +1 858 678 0760; +1 858 678 0762; [email protected]

Glenn Noronha TargeGen, Inc., 9380 Judicial Drive, CA 92121, San Diego, USA +1 858 678 0760; +1 858 678 0762; [email protected]

show all

Abstract

Background: The synthesis of novel benzotriazine heterocycles was developed independently around the same time by Bischler, Bamberger and Arndt. Over the years, different groups have reported the synthesis of benzotriazine based compounds. Objective: This literature review gives an update on recent benzotriazine compounds and their applications. Conclusion: The benzotriazine core has been used in various drug discovery projects including anticancer, anti-inflammatory and antimalarial programs. Recently, the benzotriazine core was used to develop selective kinase inhibitors targeting SRC, VEGFr2, BCR-ABL and BCR-ABL-T315I. Two benzotriazine based compounds, tirapazamine for the treatment of cancer and TG100801 for the treatment of age-related macular degeneration, have entered clinical trials.

Keywords::

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Development of novel benzotriazines for drug discovery

Information for

Open access

Opportunities

Help and information

Development of novel benzotriazines for drug discovery

Abstract

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature