https://orcid.org/0009-0006-9243-6101
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Abstract
In recent years, many studies have attempted to clarify the formation, structure and biological function of migrasomes, which are defined as specialized organelles formed by the tips and intersections of Retraction Fibrils during cell migration. It has confirmed that migrasomes were involved in various critical biological processes and diseases, and has became a new research hotspot. In this paper, we reviewed the formation and biological functions of migrasomes, explored the relationship between migrasomes, tetraspanins and hepatocellular carcinoma and discussed the potential applications of migrasomes in hepatocellular carcinoma.
Plain Language Summary
Migrasomes are specialized parts of the cell that are responsible for transporting proteins and molecules to their designated cellular locations. In this review, we have attempted to understand their formation, structure and biological function. We have also discussed the potential applications of migrasomes in liver cancer. Our study concluded that more research is required for a better understanding of migrasomes and their contents in liver cancer.
Author contributions
Conceptualization, ZB Zhang and SK Tan; writing-original draft preparation, ZQ Zhang and TM Zhang.; writing-review and editing, ZQ Zhang, TM Zhang and RC Zhang.; visualization, ZQ Zhang and RC Zhang; supervision, ZB Zhang and SK Tan. All authors read and approved the final manuscript.
Financial & competing interests disclosure
This work was supported by the National Natural Science Foundation of China (grant no. 82060621). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.
No writing assistance was utilized in the production of this manuscript.