https://orcid.org/0000-0002-4668-2970
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Abstract
Purpose
The primary aim of this work was to convert the Information System for Research in Primary Care (SIDIAP) from Catalonia, Spain, to the Observational Medical Outcomes Partnership (OMOP) Common Data Model (CDM). Our second aim was to provide a descriptive analysis of COVID-19-related outcomes among the general population.
Patients and Methods
We mapped patient-level data from SIDIAP to the OMOP CDM and we performed more than 3,400 data quality checks to assess its readiness for research. We established a general population cohort as of the 1st March 2020 and identified outpatient COVID-19 diagnoses or tested positive for, hospitalised with, admitted to intensive care units (ICU) with, died with, or vaccinated against COVID-19 up to 30th June 2022.
Results
After verifying the high quality of the transformed dataset, we included 5,870,274 individuals in the general population cohort. Of those, 604,472 had either an outpatient COVID-19 diagnosis or positive test result, 58,991 had a hospitalisation, 5,642 had an ICU admission, and 11,233 died with COVID-19. A total of 4,584,515 received a COVID-19 vaccine. People who were hospitalised or died were more commonly older, male, and with more comorbidities. Those admitted to ICU with COVID-19 were generally younger and more often male than those hospitalised and those who died.
Conclusion
We successfully transformed SIDIAP to the OMOP CDM. From this dataset, a general population cohort of 5.9 million individuals was identified and their COVID-19-related outcomes over time were described. The transformed SIDIAP database is a valuable resource that can enable distributed network research in COVID-19 and beyond.
Data Sharing Statement
In accordance with current European and national law, the data used in this study are only available for the researchers participating in this study. Thus, we are not allowed to distribute or make publicly available the data to other parties. However, researchers from public institutions can request data from SIDIAP if they comply with certain requirements. Further information is available online (https://www.sidiap.org/index.php/menu-solicitudesen/application-proccedure) or by contacting SIDIAP ([email protected]). Details on the code used for the ETL can be obtained through direct contact with the corresponding author.
Ethics Approval and Informed Consent
This study was approved by the Clinical Research Ethics Committee of the IDIAPJGol (project code: 21/052-PCV).
Acknowledgments
BR and SF-B are joint first authors. EB and TD-S are joint senior authors. We would like to acknowledge the patients who suffered or died from this devastating disease, and these patient’s families and carers. We would also like to thank the healthcare professionals in the Catalan healthcare system involved in the management of COVID-19 during these challenging times, from primary care to intensive care units; the Institut de Català de la Salut and the la Recerca i la Innovació en Salut for providing access to the different data sources accessible through SIDIAP.
Disclosure
EAV and CB are employees of Janssen Research and Development LLC and shareholders of Johnson & Johnson (J&J) stock. LH reports edenceHealth, as a certified EHDEN SME, received payment for certifying the earlier OMOP CDM transformation work done by SIDIAP in their function as an EHDEN Data Partner, during the conduct of the study. TD-S reports grants from Innovative Medicines Initiative 2, during the conduct of the study. The authors report no other conflicts of interest in this work.