Effects of Natural Products through Inhibiting Endoplasmic Reticulum Stress on Attenuation of Idiopathic Pulmonary Fibrosis

Abstract

With ever-increasing intensive studies of idiopathic pulmonary fibrosis (IPF), significant progresses have been made. Endoplasmic reticulum stress (ERS)/unfolded protein reaction (UPR) is associated with the development and progression of IPF, and targeting ERS/UPR may be beneficial in the treatment of IPF. Natural product is a tremendous source of new drug discovery, and accumulating studies have reported that many natural products show potential therapeutic effects for IPF via modulating one or more branches of the ERS signaling pathway. Therefore, this review focuses on critical roles of ERS in IPF development, and summarizes herbal preparations and bioactive compounds which protect against IPF through regulating ERS.

Keywords:

• idiopathic pulmonary fibrosis
• endoplasmic reticulum stress
• natural products
• mechanisms

Acknowledgments

This work was supported by the National Natural Science Foundation of China (Grant numbers [82304844]), the Health Profession Clinical Research Funds of Shanghai Municipal Health Commission (Grant numbers [20234Y0199]), the Natural Science Research Funds of Minhang District, Shanghai (Grant numbers [2023MHZ071]), the Scientific Research Project funded by Shanghai Municipal Science and Technology Commission (Grant numbers [21ZR1450400]), the Scientific Research Project funded by Shanghai Fifth People’s Hospital, Fudan University (Grant numbers [2020WYZD01]), and the Shanghai Municipal Health Commission clinical research project (Grant numbers [202140315]).

Disclosure

The authors report no conflicts of interest in this work.