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Abstract
Aloe barbadensis Mill. has a long history of medicinal use in the annals of traditional Chinese medicine, wherein it has garnered considerable renown. Its multifaceted therapeutic properties, characterized by its anti-inflammatory and antibacterial attributes, alongside its established efficacy as a laxative agent, have been extensively documented. This review commences with an exploration of the nomenclature, fundamental characteristics, and principal constituents of Aloe barbadensis Mill. responsible for its laxative effects. Subsequently, we delve into an extensive examination of the molecular mechanisms underlying Aloe barbadensis Mill.’s laxative properties, types of constipation treatments, commercially available preparations, considerations pertaining to toxicity, and its clinical applications. This review aims to serve as a comprehensive reference point for healthcare professionals and researchers, fostering an enhanced understanding of the optimal utilization of Aloe barbadensis Mill. in the treatment of constipation.
Graphical Abstract
Abbreviations
ALT, Alanine aminotransferase; ALP, Alkaline phosphatase; AQPs, Aquaporins; CFTR, Cystic Fibrosis Transmembrane Conductance Regulator; ENS, Enteric nervous system; GDNF, Glial cell-derived neurotrophic factor; ICC, Interstitial cells of Caja; MC, Melanosis coli; NO, Nitric oxide; SCF, Stem cell factor; SCFAs, Short-chain fatty acids; sCG, soluble guanylyl cyclase; SHTC, Shouhui tongbian Capsule; SP, Substance P; VIP, Vasoactive peptide.
Data Sharing Statement
The data used to support the findings of this study are included in the article.
Acknowledgments
The authors acknowledge the BioRender (www.biorender.com), as and the graphical abstract in this review were created with the BioRender platform.
Author Contributions
All authors made a significant contribution to the work reported, whether that is in the conception, study design, execution, acquisition of data, analysis and interpretation, or in all these areas; took part in drafting, revising or critically reviewing the article; gave final approval of the version to be published; have agreed on the journal to which the article has been submitted; and agree to be accountable for all aspects of the work.
Disclosure
The authors declare no conflicts of interest in this work.