Dysgerminoma of the Left Ovary in a Patient with Balanced Translocation 46X, t(X:1) (q22;q21): A Case Report

Abstract

We report a case of dysgerminoma in a 22-year-old woman diagnosed with chromosomal abnormality, balanced translocation 46X,t(X:1)(q22;q21). She had received hormone replacement therapy for 7 years for primary amenorrhea. She visited a primary care physician because of lower abdominal distension, and a large tumor in the pelvis was discovered. She was admitted to our hospital for further examination of the pelvic tumor. She underwent laparotomy and was diagnosed with stage IIIA1 dysgerminoma (pT3apN0pM0) of the left ovary. Young female patients without the Y chromosome who are treated for primary amenorrhea may also develop malignant germ cell tumors; therefore, gynecologists should provide hormone replacement therapy and periodic pelvic evaluation.

Keywords:

• primary amenorrhea
• balanced translocation
• dysgerminoma

Ethics Approval and Informed Consent

The case report involving a human participant was reviewed and approved by the Ethics committee of Nagasaki University Hospital, Nagasaki, Japan. After the patient has completed treatment at our hospital, she was followed at a medical facility in another prefecture. Therefore, the phone call to the patient, in which she provided verbal informed consent for the case details and images to be published was witnessed, and the contents were recorded in the patient’s medical records. The date and facility where the examination or treatment was performed are not stated, and numbers included in pathological tests and imaging tests are omitted, so that individuals cannot be identified by test results or treatment details.

Acknowledgments

We thank Cathel Kerr, BSc, PhD from Edanz Group for editing a draft of this manuscript.

Disclosure

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.