Rare Unilateral Twin Ectopic Pregnancy After Frozen Embryo Transfer: A Case Report and Literature Review

Abstract

Background

Unilateral twin ectopic pregnancy is extremely rare in natural pregnancy, with an incidence rate of only 1 in 200,000–2,500,000, represents a major health risk for reproductive-aged women, leading to even life-threatening complications. There is a lack of data on the prevalence of this rare disease after in-vitro fertilization-embryo transfer (IVF-ET) cycles.

Case Report

We present a case of a 51-year-old woman with rare unilateral twin ectopic pregnancy after frozen embryo transfer treated with bilateral salpingectomy, followed by a review of the literature.

Conclusion

Twin ectopic pregnancy is a very rare type of pregnancy that requires a high index of suspicion to diagnose and treat early to prevent complications and maternal death.

Keywords:

• twin ectopic
• pregnancy
• unilateral
• rare condition
• assisted reproductive technology

Ethics Approval and Consent to Participate

The protocol was approved by the Ethics Committee of Shanxi Maternal and Child Health Care Hospital (IRB-KY-2017).

Consent for Publication

The patient’s written consent has been obtained for publication.

Disclosure

The authors declare that they have no competing interests.

Additional information

Funding

This study was supported by National Natural Science Foundation of China (grant no. 82000722 and 82000302), Natural Science Foundation of Shanxi (grant no. 201901D211519 and 201901D211546), Research Project Supported by Shanxi Scholarship Council of China (grant no. HGKY2019092), China Postdoctoral Science Foundation (grant no. 2020 M670703), Initial Scientific Research Fund of PhD in Shanxi Provincial People’s Hospital (grant no. b201635), Fund Program for the Scientific Activities of Selected Returned Overseas Professionals in Shanxi Province (grant no. 20200033 and 20220050), Key Research and Development Projects of Shanxi Province (grant no. 188821) and Medical and Technological Innovation Team of Shanxi (grant no. 2020TD19).