Sacubitril/Valsartan Shows Improvement of the Cardio-Ankle Vascular Index in a Hypertensive Patient

Abstract

A 72-year-old man presented to our clinic with hypertension. Arterial stiffness evaluated by cardio ankle vascular index (CAVI) was markedly increased at 13.5. We treated him using 80 mg/day of valsartan for three months. CAVI was decreased from 13.5 to 13.0. However, his BP fluctuations were still high. We changed the treatment to angiotensin receptor-neprilysin inhibitor (ARNI) with increasing doses up to 400 mg. Independent of the change in blood pressure at the time of measurement, CAVI improved with ARNI dose. Hypertension treatment with an awareness of the cardio-vascular interaction might be a possibility prevents future heart failure development effectively.

Keywords:

• hypertension
• angiotensin receptor-neprilysin inhibitor
• arterial stiffness
• cardio ankle vascular index

Institutional Approval

This case report was approved by Toho University (2022-154).

Consent

The authors confirm that written consent for submission and publication of this case report including images and associated text has been obtained from the patient in line with CARE guidance.

Acknowledgments

The authors thank Kohji Shirai, Honorary Professor of Toho University.

Disclosure

The authors state that they have no conflict of interest.

Additional information

Funding

The authors declare no funding information.