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Abstract
Background
Indonesia is a country with high biodiversity of more than 20,000 plant species, and 35% of them are identified as having health benefits. Moringa oleifera is one plant that almost all of its parts have been used as nutritional supplements and traditional medicines. Moringa leaves contain nutrients, antioxidants, and bioactive substances that have anti-inflammatory, wound healing, and anti-anemia properties.
Purpose
This study aimed to investigate the hematological effect of Moringa leaf powder in male Wistar rats under normal conditions.
Methods
Twenty-four male Wistar rats strain (Rattus norvegicus) 9−10 weeks old and 250−275 grams were divided into four groups (n=6), normal as a control group and three other groups were given Moringa leaf powder at doses 200, 400, and 800 mg/kgBW during 12 weeks. Blood samples at week 12 were administered to determine blood count.
Results
The results of this study showed differences between the various doses of Moringa leaf powder for each hematological profile. These differences were more significant for MCH parameters that indicated a decrease in the D800 group compared with the control group.
Conclusion
In conclusion, this study revealed that the consumption of Moringa leaf powder for 12 weeks did not have a significant change in the hematological profile, except for the MCH value that revealed a modification.
Acknowledgments
The authors would like to thank to Putri Teesa Radhiyanti Santoso, dr., M.Kes, Ph.D, Hanna, dr., M.Kes, AIFO, Ph.D., Resti Gradia Dwiwina, dr., M.Kes for article reviewer and examiner, and Mr Gilang for assisting in animal treatment. We would also like to thank Universitas Padjadjaran, for funding this research through Riset Disertasi Dosen Universitas Padjadjaran (2203/UN6.3.1/PT.00/2022).
Author Contributions
All authors made a significant contribution to the work reported, whether that is in the conception, study design, execution, acquisition of data, analysis and interpretation, or in all these areas; took part in drafting, revising or critically reviewing the article; gave final approval of the version to be published; have agreed on the journal to which the article has been submitted; and agree to be accountable for all aspects of the work.
Disclosure
Mrs Vita Murniati Tarawan reported grants from Universitas Padjadjaran during the conduct of the study. The authors report no other conflicts of interest in this work.