Inhibition and Heart Rate Variability in Experimentally Induced Pain

Abstract

Introduction

Pain is a complex experience that requires executive functions (EFs) to be processed. The autonomic outcome of the neural networks involved in the cognitive evaluation of pain is reflected by heart rate variability (HRV), an index of self-regulation abilities. Although some results suggest a relationship between HRV, EFs, and pain, studies focusing on this three-way relationship are still scarce.

Objective

This study aims to investigate the relationship between pain, cognitive, and autonomic mechanisms, hypothesizing an association between resting HRV and both cognitive and motor inhibition as indices of executive functioning. This relationship was investigated after an experimental-induced pain.

Methods

Seventy-six young adults were exposed to the Cold Pressure Arm Warp to induce experimental pain. HRV was collected, and cognitive tasks were administered to assess executive performance.

Results

The results showed that (1) HRV indices significantly increased during pain stimulation, (2) cognitive inhibition was positively correlated with vagal indices and with pain parameters, (3) both inhibition tasks significantly predicted pain threshold while the performance on the Stroop Task predicted pain tolerance.

Conclusion

Results suggest a three-way relationship. Further research would focus on the role of HRV and cognitive strategies in pain management in chronic pain conditions.

Keywords:

• Stroop task
• Go-NoGo
• autonomic
• pain
• heart rate variability
• cognition

Acknowledgments

This paper was funded by Sapienza University of Rome (“Progetti di Ricerca Grandi”; protocol number: RG1221816C3B6C27).

Disclosure

The authors declare no conflicts of interest in this work.