Bibliometric Analysis of Research on Migraine-Stroke Association from 2013 to 2023

Abstract

Background

Both migraine and stroke heavily burden individuals, health systems, and society. The migraine-stroke association is of concern and has been studied widely. Our objective is to explore and overview the current research status and emerging trends.

Materials and Methods

Studies on migraine-stroke association from January 2013 to May 2023 were retrieved and screened from the Web of Science Core Collection (WOSCC) database. Records fulfilling the selection criteria were downloaded and imported into CiteSpace for data mining and visualization.

Results

A total of 862 papers on migraine-stroke association were included. Annual publications grew slowly. The United States and European countries dominated research in this area. Harvard University published the largest number of articles, while the University of London was most active with other institutions. Ayata Cenk contributed the most articles, while KURTH T and NEUROLOGY were co-cited most. Research hotspots included migraine with aura, ischemic stroke, patent foramen ovale, cortical spreading depolarization, meta-analysis, cross-sectional study, and risk factors. Pathophysiology and small vessel disease represented research frontiers and emerging trends.

Conclusion

Our study scientifically outlines the migraine-stroke association over the past decade, presenting useful information.

Keywords:

• migraine with aura
• ischemic stroke
• patent foramen ovale
• cortical spreading depolarization
• pathophysiology
• CiteSpace

Abbreviations

CADASIL, cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy; CBF, cerebral blood flow; CGRP, calcitonin gene-related peptides; CSD, Cortical spreading depolarization; FMD, flow-mediated dilation; GOM, granular osmiophilic materials; ICHD-3, the 3rd edition of International Classification of Headache Disorders; IF, impact factor; IPSC, induced pluripotent stem cell; MA, migraine with aura; MO, migraine without aura; MR, Mendelian randomization; OR, Odds Ratio; PFO, patent foramen ovale; RCT, randomized controlled trial; RLS, right-to-left shunt; SVD, small vessel disease; WOSCC, Web of Science Core Collection.

Acknowledgments

Thanks to Chaomei Chen for inventing CiteSpace.

Disclosure

The authors report no conflicts of interest in this work.

Additional information

Funding

This work was supported by the Hospital level project of Shanghai Sixth People’s Hospital (ynlc201827), Natural Science Foundation of Shandong Province (ZR2020MH156), and Shaanxi Key Laboratory of Research on TCM Physical Constitution and Diseases Prevention and Treatment (KF202310).