Tiragolumab (Anti-TIGIT) in SCLC: Skyscraper-02, a Towering Inferno

Abstract

Small cell lung cancer (SCLC) is characterized by rapid progression and poor prognosis. Although the phase II CITYSCAPE-02 trial found objective response rate (ORR) and progression-free survival (PFS) of non-small cell lung cancer (NSCLC) patients improved when tiragolumab was added to atezolizumab and chemotherapy, the phase III SKYSCRAPER-02 failed to find PFS or OS benefit in patients with SCLC. Atezolizumab was the first immunotherapy to show survival benefit in extensive SCLC based on the phase III IMpower133 study. Given that immunotherapy has become the standard of care for SCLC patients, further research is needed into ways to augment the immune system to better treat these patients.

Keywords:

• tiragolumab
• TIGIT
• immunotherapy
• small cell lung cancer

Abbreviations

ALK, anaplastic lymphoma kinase; CD8, cluster of differentiation 8; CD155, cluster of differentiation 155; CD226, cluster of differentiation 226; CTLA-2, cytotoxic T lymphocyte-associated antigen 4; DOR, duration of response; ECOG, Eastern Cooperative Oncology Group; EGFR, epidermal growth factor receptor; FDA, Federal Drug Administration; HR, hazard ratio; MAPK, mitogen-activated protein kinase; NF-kB, nuclear factor kappa beta; NK, natural killer; NSCLC, non-small cell lung cancer; ORR, objective response rate; OS, overall survival; PD-1, programmed cell death 1; PD-L1, programmed death-ligand 1; PFS, progression-free survival; PI3K, phosphoinositide 3 kinase; SCLC, small cell lung cancer; TIGIT, T-cell immunoglobulin and ITIM domain; TNF, tumor necrosis factor.

Disclosure

SIO has stock ownership and was on the scientific advisory board of Turning Point Therapeutics Inc (until Feb 28, 2019); is a member of the SAB of Elevation Oncology and has stock ownership; honoraria from AstraZeneca, Caris Life Science, Daiichi Sankyo, DAVA Oncology LLP, Janssen/JNJ, Merck, Pfizer, Roche/Genentech, Takeda/ARIAD, BeiGene. MN reports honorarium/consulting from/for AstraZeneca, Daiichi Sankyo, Takeda, Novartis, EMD Serono, Janssen, Pfizer, Eli Lilly, Genentech, Mirati, Caris Life Sciences, Blueprint Medicines; travel support from AnHeart Therapeutics. The authors report no other conflicts of interest in this work.

Additional information

Funding

No funding was secured for this report.